US4011322A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Benzimidazole derivatives and process for the production thereof
Assignee: Bayer Pharma AG
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Filing: 1975-07-28
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Granted: 1977-03-08
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Expires: 1995-07-28
Abstract
Abstract Benzimidazoles of the formula ##STR1## wherein R 1 is o-hydroxyphenyl, a p-chlorophenyl, or p-fluorophenyl, and R 2 is an alkyl of 2-4 carbon atoms, and physiologically acceptable acid addition salts thereof possess topical anti-inflammatory activity.
Inventors
- 👤 Dieter Rahtz
- 👤 Hans Wendt
- 👤 Henning Koch
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 21:27
CPC Classifications
C; C07; C07D; C07D235/00; C07D235/02; C07D235/04; C07D235/06; C07D235/10
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
33 words
A benzimidazole derivative of the formula ##STR9## wherein R 1 is o-hydroxyphenyl, p-chlorophenyl, or p-fluorophenyl, and R 2 is an alkyl of 2-4 carbon atoms, or a physiologically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
33 words
A benzimidazole derivative of the formula ##STR9## wherein R 1 is o-hydroxyphenyl, p-chlorophenyl, or p-fluorophenyl, and R 2 is an alkyl of 2-4 carbon atoms, or a physiologically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
10 words
A compound of claim 1, wherein R 2 is ethyl.
Claim 4
Dependent Claim
10 words
A compound of claim 1 wherein R 2 is n-propyl.
Claim 5
Dependent Claim
14 words
A compound of claim 1, 2-(4-ethyl-1-piperazinyl)-methyl-1-(2-hydroxybenzyl)-benzimidazole or a physiologically acceptable acid addition salt thereof.
Claim 6
Dependent Claim
14 words
A compound of claim 1, 2-(4-propyl-1-piperazinyl)-methyl-1-(4-fluorobenzyl)-benzimidazole or a physiologically acceptable acid addition salt thereof.
Claim 7
Dependent Claim
14 words
A compound of claim 1, 2-(4-ethyl-1-piperazinyl)-methyl-1-(4-chlorobenzyl)-benzimidazole or a physiologically acceptable acid addition salt thereof.
Claim 8
Dependent Claim
27 words
A pharmaceutical composition adapted for topical administration consisting essentially of an anti-inflammatorily effective concentration of a compound of claim 1 in admixture with a pharmaceutically acceptable carrier.
Claim 9
Dependent Claim
29 words
A method for the treatment of inflammations of the skin which consists essentially of applying to the affected area an anti-inflammatorily effective amount of a compound of claim 1.
References Cited (Backward Citations)
US3658822A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-03-07 | 1980-09-06 | 1981-03-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-03-07 | 1984-09-06 | 1985-03-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-03-07 | 1988-09-06 | 1989-03-08 | $7700.00 | Window Closed / Lapsed |