US4010279A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Biphenyloxy derivatives and antihyperlipidemic use
Assignee: Boehringer Ingelheim GmbH
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Filing: 1975-12-23
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Granted: 1977-03-01
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Expires: 1995-12-23
Abstract
Abstract Compounds of the formula ##STR1## wherein R 1 is straight or branched alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, phenylalkyl, phenylalkenyl, pyridyl or ##STR2## where X, Y and Z are each hydrogen, halogen, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 3 carbon atoms, R 2 is hydrogen or alkyl of 1 to 4 carbon atoms, R 3 is hydroxymethyl, carboxyl, alkoxycarbonyl of 2 to 7 carbon atoms or cycloalkoxycarbonyl or 4 to 8 carbon atoms, A is --CO--NH-- or --NH--CO--, and n is 1, 2 or 3, And, when R 3 is carboxyl, non-toxic salts thereof formed with an inorganic or organic base; the compounds as well as the salts are useful as antihyperlipidemics.
Inventors
- 👤 Gerhart Griss
- 👤 Wolfgang Grell
- 👤 Rudolf Hurnaus
- 👤 Robert Sauter
- 👤 Bernhard Eisele
- 👤 Nikolaus Kaubisch
- 👤 Matyas Leitold
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 09:23
CPC Classifications
C; C07; C07D; C07D209/00; C07D209/02; C07D209/44; C07D209/48; C07C; C07C217/00; C07C217/54; C07C217/56; C07C217/62; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/78; C07D213/81; C07D213/82
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
94 words
A compound of the formula ##STR15## wherein R 1 is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, phenylalkyl, phenylalkenyl or ##STR16## where X, Y and Z are each hydrogen, halogen, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 3 carbon atoms, R 2 is hydrogen or alkyl of 1 to 4 carbon atoms, R 3 is alkoxycarbonyl of 2 to 7 carbon atoms or cycloalkoxycarbonyl of 4 to 8 carbon atoms, A is --CO-NH-- or --NH-Co--, and n is 1, 2 or 3.
Claim 2
Dependent Claim
94 words
A compound of the formula ##STR15## wherein R 1 is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, phenylalkyl, phenylalkenyl or ##STR16## where X, Y and Z are each hydrogen, halogen, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 3 carbon atoms, R 2 is hydrogen or alkyl of 1 to 4 carbon atoms, R 3 is alkoxycarbonyl of 2 to 7 carbon atoms or cycloalkoxycarbonyl of 4 to 8 carbon atoms, A is --CO-NH-- or --NH-Co--, and n is 1, 2 or 3.
Claim 3
Dependent Claim
93 words
A compound of claim 1, which is of the formula ##STR17##wherein R 1 is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, phenylalkyl, phenylalkenyl or ##STR18## were X, Y and Z are each hydrogen, halogen, alkyl or 1 to 3 carbon atoms or alkoxy of 1 to 3 carbon atoms, R 2 is hydrogen or alkyl of 1 to 4 carbon atoms, R 3 is alkoxycarbonyl of 2 to 7 carbon atoms or cycloalkoxycarbonyl of 4 to 8 carbon atoms, and n is 1, 2 or 3.
Claim 4
Dependent Claim
46 words
A compound of claim 2, which is of the formula ##STR19##wherein R 2 is hydrogen or methyl, R 3 is carbalkoxy of 2 to 5 carbon atoms, X and Y are each hydrogen, fluorine, chlorine, bromine, methyl or mexthoxy, and n is 1, 2 or 3.
Claim 5
Dependent Claim
9 words
The compound of claim 3 which is ethyl 2-methyl-2-{4-[2-(2-methoxy-5-chloro-benzamido)-ethyl]-biphenyl-4'-oxy}-propionate.
Claim 6
Dependent Claim
9 words
The compound of claim 3 which is ethyl 2-methyl
Claim 7
Dependent Claim
24 words
An antihyperlipidemic pharmaceutical dosage unit composition consisting essentially of an inert pharmaceutical carrier and an effective antihyperlipidermic amount of a compound of claim 1.
Claim 8
Dependent Claim
40 words
The method of lowering the level of lipids in the blood of a warm-blooded animal in need of such treatment, which comprises perorally, parenterally or rectally admininstering to said animal an effective antihyperlipidemic amount of a compound of claim 1.
References Cited (Backward Citations)
US3914286A
Cited
US3781328A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-02-29 | 1980-08-30 | 1981-03-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-02-29 | 1984-08-30 | 1985-03-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-02-29 | 1988-08-30 | 1989-03-01 | $7700.00 | Window Closed / Lapsed |