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US4010272A
Expired / Lapsed
US
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Anthelmintically active basically substituted 2-carbalkoxy-amino-benzimidazolyl-5(6)-phenyl ethers and -ketones
Assignee: Hoechst AG
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Filing: 1975-09-08
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Granted: 1977-03-01
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Expires: 1995-09-08
Abstract
Abstract Anthelmintically active basically substituted 2-carbalkoxy-amino-benzimidazolyl-5(6)-phenyl ethers and -ketones are disclosed as well as a process for preparing them. The compounds are chemotherapeutics having a particular activity against ankylostomes, other helminths as well as liver fluke.
Inventors
- 👤 Heinz Loewe
- 👤 Josef Urbanietz
- 👤 Dieter Duwel
- 👤 Reinhard Kirsch
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 12:40
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/04; C07D295/08; C07D295/084; C07D295/088; C07D235/00; C07D235/02; C07D235/04; C07D235/24; C07D235/30; C07D235/32
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
82 words
A basically substituted 2-carbalkoxyamino-benzimidazolyl5-(6)-phenyl ether or -ketone of the formula ##STR10##wherein R 3 is alkyl having 1 to 4 carbon atoms, X is oxygen, sulfur or ##STR11##Y is a straight-chained or branched alkylene of 1 to 4 carbon atoms and R 1 and R 2 represent alkyl having 1 to 4 carbon atoms, whereby R 1 and R 2 together with the supporting nitrogen atom may also represent pyrrolidine, piperidine, morpholine or thiomorpholine, and a salt thereof with a physiologically tolerable acid.
Claim 2
Dependent Claim
82 words
A basically substituted 2-carbalkoxyamino-benzimidazolyl5-(6)-phenyl ether or -ketone of the formula ##STR10##wherein R 3 is alkyl having 1 to 4 carbon atoms, X is oxygen, sulfur or ##STR11##Y is a straight-chained or branched alkylene of 1 to 4 carbon atoms and R 1 and R 2 represent alkyl having 1 to 4 carbon atoms, whereby R 1 and R 2 together with the supporting nitrogen atom may also represent pyrrolidine, piperidine, morpholine or thiomorpholine, and a salt thereof with a physiologically tolerable acid.
Claim 3
Dependent Claim
51 words
A compound as defined in claim 1, wherein R 3 is methyl, x is oxygen, sulfur or ##STR12##, Y is-(CH 2 ) 2 -- or --(CH 2 ) 3 -- and R 1 and R 2 are methyl or ethyl or together with the nitrogen atom carrying them the piperidine ring.
Claim 4
Dependent Claim
10 words
The compound as claimed in claim 1 which is 3-(2-piperidyl-ethoxy)-phenyl-2-carbomethoxyamino-benzimidazolyl-5(6)-ether.
Claim 5
Dependent Claim
10 words
The compound as claimed in claim 1 which is 3-(2-dimethyl-amino-ethoxy)-phenyl-2-carbomethoxyamino-benzimidazolyl-5(6)-ether.
Claim 6
Dependent Claim
10 words
The compound as claimed in claim 1 which is 3-(dimethylamino-propoxy)-phenyl-2-carbomethoxyamino-benzimidazolyl5(6)-ether.
Claim 7
Dependent Claim
10 words
The compound as claimed in claim 1 which is 4-(2-dimethyl-amino-ethoxy)-phenyl-2-carbomethoxyamino-benzimidazolyl-5(6)-ether.
Claim 8
Dependent Claim
10 words
The compound as claimed in claim 1 which is 4-(2-diethylamino-ethoxy)-phenyl-2-carbomethoxyamino-benzimidazolyl-5(6)-ether.
Claim 9
Dependent Claim
10 words
The compound as claimed in claim 1 which is 4-(2-piperidyl-ethoxy)-phenyl-2-carbomethoxyamino-benzimidazolyl-5(6)-ether.
Claim 10
Dependent Claim
11 words
The compound as claimed in claim 1 which is 4-(2-diethylamino-ethoxy)-phenyl-2-carbomethoxyamino-benzimidazolyl-5(6)-thio ether.
Claim 11
Dependent Claim
10 words
The compound as claimed in claim 1 which is 4-(2-diethylamino-ethoxy)-phenyl-2-carbomethoxyamino-benzimidazolyl-5(6)-ketone.
Claim 12
Dependent Claim
25 words
Anthelmintic composition containing as the active ingredient an effective amount of a compound as claimed in claim 1 in admixture with a pharmaceutically acceptable carrier.
Claim 13
Dependent Claim
22 words
Method of combatting helminths which comprises administering an effective amount of a compound as claimed in claim 1 to the infected organism.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-02-29 | 1980-08-30 | 1981-03-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-02-29 | 1984-08-30 | 1985-03-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-02-29 | 1988-08-30 | 1989-03-01 | $7700.00 | Window Closed / Lapsed |