US4009283A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antiinflammatory and antithrombotic compositions and method of use
Assignee: Pharmacia and Upjohn Co
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Filing: 1976-02-06
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Granted: 1977-02-22
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Expires: 1996-02-06
Abstract
Abstract In accordance with this invention, there are disclosed compounds of the formula ##STR1## wherein X is selected from the group consisting of nitro and amino with the proviso that when Y is hydrogen, X is nitro; Y is selected from the group consisting of hydrogen and fluoro; R is selected from the group consisting of hydrogen and alkyl of from one to six carbon atoms, inclusive. These compounds are compounded into pharmaceutical compositions and administered to mammals for purposes of relieving inflammation and to mammals in need of prophylactic anti-thrombotic treatment.
Inventors
- 👤 Milton E. Herr
- 👤 Roy A. Johnson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 17:13
CPC Classifications
C; C07; C07C; C07C205/00; C07C205/45
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
35 words
A pharmaceutical composition which comprises an antiinflammatory effective amount of a compound of the formula ##STR3## wherein R is hydrogen or alkyl of one to six carbon atoms, inclusive, in association with a pharmaceutical carrier.
Claim 2
Dependent Claim
35 words
A pharmaceutical composition which comprises an antiinflammatory effective amount of a compound of the formula ##STR3## wherein R is hydrogen or alkyl of one to six carbon atoms, inclusive, in association with a pharmaceutical carrier.
Claim 3
Dependent Claim
13 words
A composition in accordance with claim 1 suitable for oral or parenteral use.
Claim 4
Dependent Claim
11 words
A composition in accordance with claim 2 wherein R is hydrogen.
Claim 5
Dependent Claim
56 words
A pharmaceutical composition which comprises an anti-thrombotic effective amount of a compound of the formula ##STR4## wherein X is nitro or amino and when X is nitro, Y is hydrogen and when X is amino, Y is fluoro, R is hydrogen or alkyl of one to six carbon atoms, inclusive, in association with a pharmaceutical carrier.
Claim 6
Dependent Claim
56 words
A pharmaceutical composition which comprises an anti-thrombotic effective amount of a compound of the formula ##STR4## wherein X is nitro or amino and when X is nitro, Y is hydrogen and when X is amino, Y is fluoro, R is hydrogen or alkyl of one to six carbon atoms, inclusive, in association with a pharmaceutical carrier.
Claim 7
Dependent Claim
13 words
A composition in accordance with claim 4 suitable for oral or parenteral use.
Claim 8
Dependent Claim
11 words
A composition in accordance with claim 5 wherein R is hydrogen.
Claim 9
Independent Claim
49 words
A method for obtaining an anti-inflammatory effect in a mammal which comprises administering to a mammal an anti-inflammatory effective amount of compound ##STR5## wherein R is selected from the group consisting of hydrogen and alkyl of from one to six carbon atoms, inclusive, in association with a pharmaceutical carrier.
Claim 10
Independent Claim
49 words
A method for obtaining an anti-inflammatory effect in a mammal which comprises administering to a mammal an anti-inflammatory effective amount of compound ##STR5## wherein R is selected from the group consisting of hydrogen and alkyl of from one to six carbon atoms, inclusive, in association with a pharmaceutical carrier.
Claim 11
Dependent Claim
14 words
A method in accordance with claim 7 wherein the administration is oral or parenteral.
Claim 12
Independent Claim
100 words
A method for obtaining an anti-thrombotic effect in a mammal in need thereof which comprises administering to a mammal an anti-thrombotic effective amount of a compound selected from the group consisting of ##STR6## wherein X is selected from the group consisting of nitro and amino Y is selected from the group consisting of hydrogen and fluoro with the proviso that when X is nitro, Y is hydrogen and when X is amino, Y is fluoro, and R is selected from the group consisting of hydrogen and alkyl from one to six carbon atoms, inclusive, in association with a pharmaceutical carrier.
Claim 13
Independent Claim
100 words
A method for obtaining an anti-thrombotic effect in a mammal in need thereof which comprises administering to a mammal an anti-thrombotic effective amount of a compound selected from the group consisting of ##STR6## wherein X is selected from the group consisting of nitro and amino Y is selected from the group consisting of hydrogen and fluoro with the proviso that when X is nitro, Y is hydrogen and when X is amino, Y is fluoro, and R is selected from the group consisting of hydrogen and alkyl from one to six carbon atoms, inclusive, in association with a pharmaceutical carrier.
Claim 14
Dependent Claim
14 words
A method in accordance with claim 9 wherein the administration is oral or parenteral.
Claim 15
Dependent Claim
11 words
A method in accordance with claim 8 wherein R is hydrogen.
Claim 16
Dependent Claim
11 words
A method in accordance with claim 10 wherein R is hydrogen.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-02-22 | 1980-08-23 | 1981-02-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-02-22 | 1984-08-23 | 1985-02-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-02-22 | 1988-08-23 | 1989-02-22 | $7700.00 | Window Closed / Lapsed |