US4008208A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Compositions having inhibited ability to promote platelet aggregation or fibrin clot formation
Assignee: Pharmacia and Upjohn Co
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Filing: 1975-03-17
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Granted: 1977-02-15
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Expires: 1995-03-17
Abstract
Abstract A composition which comprises a substance which is a substituted aromatic and which inhibits the thrombotic or clotting activity of a material, chemically bonded through an --N=N-- grouping to a second aromatic which is chemically bonded at a sulfonyl grouping through a nitrogen containing chemical bond to a material which is susceptible to interaction with a nitrene.
Inventors
- 👤 Daniel Lednicer
- 👤 Edward E. Nishizawa
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 18:07
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/655; C; C08; C08F; C08F8/00; C08F8/30
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
44 words
A composition which comprises a sulfonyl aromatic diazonium salt chemically bonded at the sulfonyl grouping through a nitrogen-containing bond to a material which is susceptible to interaction with a nitrene which induces deposition of blood cells and fibrin when in contact with mammalian blood.
Claim 2
Dependent Claim
44 words
A composition which comprises a sulfonyl aromatic diazonium salt chemically bonded at the sulfonyl grouping through a nitrogen-containing bond to a material which is susceptible to interaction with a nitrene which induces deposition of blood cells and fibrin when in contact with mammalian blood.
Claim 3
Dependent Claim
68 words
A composition which comprises ##STR4## wherein X is nitro or amino, R and R 1 are the same or different and are each selected from the group consisting of hydrogen, halogen, and alkyl of one to four carbon atoms, inclusive; and C is a material which is susceptible to interaction with an aromatic nitrene which induces deposition of blood cells and fibrin when in contact with mammalian blood.
Claim 4
Dependent Claim
68 words
A composition which comprises ##STR4## wherein X is nitro or amino, R and R 1 are the same or different and are each selected from the group consisting of hydrogen, halogen, and alkyl of one to four carbon atoms, inclusive; and C is a material which is susceptible to interaction with an aromatic nitrene which induces deposition of blood cells and fibrin when in contact with mammalian blood.
Claim 5
Dependent Claim
11 words
A composition in accordance with claim 2 wherein X is nitro.
Claim 6
Dependent Claim
11 words
A composition in accordance with claim 2 wherein X is amino.
Claim 7
Dependent Claim
73 words
A composition which comprises a substituted aromatic compound that inhibits the thrombotic or clotting activity of a material susceptible to interaction with a sulfonylnitrene, said material being one which induces deposition of blood cells and fibrin when in contact with mammalian blood, said substituted aromatic compound is chemically bonded to a phenyl, monosubstituted phenyl, or disubstituted phenyl, which is chemically bonded to a sulfonyl group through a nitrogen-containing chemical bond to said material.
Claim 8
Dependent Claim
73 words
A composition which comprises a substituted aromatic compound that inhibits the thrombotic or clotting activity of a material susceptible to interaction with a sulfonylnitrene, said material being one which induces deposition of blood cells and fibrin when in contact with mammalian blood, said substituted aromatic compound is chemically bonded to a phenyl, monosubstituted phenyl, or disubstituted phenyl, which is chemically bonded to a sulfonyl group through a nitrogen-containing chemical bond to said material.
Claim 9
Dependent Claim
22 words
A composition in accordance with claim 5 wherein the material is a synthetic or natural polymer with a plurality of carbon-hydrogen bonds.
Claim 10
Dependent Claim
28 words
A composition in accordance with claim 6 wherein the nitrogen-containing bond to the material is a covalent bond between the nitrogen and a carbon atom of the material.
Claim 11
Dependent Claim
46 words
A composition in accordance with claim 7 wherein the phenyl, monosubstituted phenyl or disubstituted phenyl is ##STR5## wherein R and R 1 are the same or different and are selected from the group consisting of hydrogen, halogen, and alkyl of one to four carbon atoms, inclusive.
Claim 12
Dependent Claim
14 words
A composition in accordance with claim 6 wherein the material is polyethylene or polypropylene.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-02-15 | 1980-08-16 | 1981-02-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-02-15 | 1984-08-16 | 1985-02-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-02-15 | 1988-08-16 | 1989-02-15 | $7700.00 | Window Closed / Lapsed |