US4008124A
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Process for the isomerization of glucose into fructose
Assignee: Mitsubishi Chemical Corp
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Filing: 1975-06-20
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Granted: 1977-02-15
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Expires: 1995-06-20
Abstract
Abstract There is disclosed a process for isomerization of glucose into fructose which comprises contacting an aqueous glucose solution with glucose isomerase in the presence of iron ion and magnesium ion, said glucose isomerase being in the form of insolubilized glucose isomerase adsorbed on a carrier.
Inventors
- 👤 Yoshimasa Fujita
- 👤 Akiyoshi Matsumoto
- 👤 Hachiro Ishikawa
- 👤 Tadashi Hishida
- 👤 Hideo Kato
- 👤 Hiroshi Takamisawa
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 15:43
CPC Classifications
C; C08; C08B; C08B37/00; C08B37/0006; C08B37/0036; C08B37/0039; C12; C12N; C12N11/00; C12N11/02; C12N11/08; C12N11/082; C12N11/10; C12P; C12P19/00; C12P19/24; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/886
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
44 words
A process for the isomerization of glucose into fructose by contacting an aqueous glucose solution with glucose isomerase wherein iron ion together with magnesium ion is present in the reaction mixture at concentrations of 0.005 to 5 mM/1 and 2 to 20 mM/1, respectively.
Claim 2
Dependent Claim
44 words
A process for the isomerization of glucose into fructose by contacting an aqueous glucose solution with glucose isomerase wherein iron ion together with magnesium ion is present in the reaction mixture at concentrations of 0.005 to 5 mM/1 and 2 to 20 mM/1, respectively.
Claim 3
Dependent Claim
24 words
A process for the isomerization of glucose into fructose according to claim 1, wherein said glucose isomerase is in the form of insolubilized isomerase.
Claim 4
Dependent Claim
29 words
A process for the isomerization of glucose into fructose according to claim 1, wherein said glucose isomerase is in the form of insolubilized isomerase adsorbed on an ion exchanger.
Claim 5
Dependent Claim
31 words
A process for the isomerization of glucose into fructose according to claim 1, wherein said glucose isomerase is in the form of insolubilized isomerase adsorbed on a macroporous anion exchange resin.
Claim 6
Dependent Claim
33 words
A process for the isomerization of glucose into fructose according to claim 1, wherein said glucose isomerase is in the form of insolubilized isomerase adsorbed on a cyanogen halide derivative of cross-linked agar.
Claim 7
Dependent Claim
25 words
A process for the isomerization of glucose into fructose according to claim 1, wherein said glucose isomerase is isolated from the microbial cells of Streptomyces.
Claim 8
Dependent Claim
33 words
A process for the isomerization of glucose into fructose according to claim 1, wherein the concentrations of magnesium ion and iron ion are 2 to 20 mM. and 0.02 to 0.5 mM., respectively.
Claim 9
Dependent Claim
57 words
A process for the isomerization of glucose into fructose according to claim 1, wherein the iron ion source is ferrous sulfate, ferric sulfate, ferrous chloride, ferric chloride, ammonium ferrous sulfate, ammonium ferric sulfate, iron tartarate or a mixture thereof and the magnesium ion source is magnesium sulfate, magnesium chloride, magnesium sulfite, magnesium carbonate or a mixture thereof.
Claim 10
Dependent Claim
59 words
A process for the isomerization of glucose into fructose which comprises passing an aqueous glucose solution containing iron ion at a concentration of 0.005 to 5 mM. and magnesium ion at a concentration of from 2 to 20 mM. through a bed of glucose isomerase isolated from microbial cells of Streptomyces and adsorbed on a macroporous anion exchange resin.
Claim 11
Dependent Claim
59 words
A process for the isomerization of glucose into fructose which comprises passing an aqueous glucose solution containing iron ion at a concentration of 0.005 to 5 mM. and magnesium ion at a concentration of from 2 to 20 mM. through a bed of glucose isomerase isolated from microbial cells of Streptomyces and adsorbed on a macroporous anion exchange resin.
Claim 12
Dependent Claim
45 words
A process for the isomerization of glucose into fructose according to claim 9, wherein said macroporous anion exchange resin is a macroporous strong base ion exchange resin the matrix of which comprises a copolymer of styrene-divinyl benzene and ion exchange group is a quarternary ammonium.
Claim 13
Dependent Claim
25 words
A process for the isomerization of glucose into fructose according to claim 9, wherein said concentration of iron ion is from 0.02 to 0.5 mM/l.
Claim 14
Dependent Claim
45 words
A process for the isomerization of glucose into fructose according to claim 9, wherein the iron ion source present in the aqueous glucose solution is ferrous sulfate, ferric sulfate, ferrous chloride, ferric chloride, iron tartarate, ammonium ferrous sulfate, ammonium ferric sulfate or a mixture thereof.
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