US4007271A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Dermatalogical compounds and compositions
Assignee: STWB Inc
•
Filing: 1976-05-21
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Granted: 1977-02-08
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Expires: 1996-05-21
Abstract
Abstract Mono-, di- or tri-(X,Y-substituted-benzoyl) esters of 1,8,9-trihydroxyanthracene, wherein the anthracene moiety can be substituted by methyl at the 3-position, X is halogen, hydroxy, nitro, lower-alkyl, lower-alkoxy, phenoxy, trifluoromethyl, lower-alkylcarboxy or lower-alkoxycarbonyl and Y is hydrogen or has the meaning given hereinabove for X, are prepared by reacting the appropriate 1,8,9-trihydroxyanthracene with the appropriate substituted-benzoic acid or functional derivative thereof, e.g., acid chloride, in an inert solvent, in the presence of a suitable basic catalyst, e.g., pyridine or triethylamine, and under an inert atmosphere. Pharmaceutical compositions comprising these esters are useful in treating dermatological conditions such as psoriasis and have the improvements of having substantially no undesirable staining and irritating properties.
Inventors
- 👤 Andrew Robertson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 16:19
CPC Classifications
C; C07; C07C; C07C69/00; C07C69/76; C07C69/78; C07C205/00; C07C205/49; C07C205/57; C07C69/84; C07C69/88; C07C69/92; C07C2603/00; C07C2603/02; C07C2603/04; C07C2603/22; C07C2603/24
Claims Analysis
Total Claims: 38
Claim 1
Independent Claim
62 words
A compound having the formula: ##STR4## wherein: each R is a hydrogen atom or an X,Y-substituted-benzoyl group, at least one R being an X,Y-substituted-benzoyl group; X is a halogen atom, hydroxy, nitro, lower-alkyl, lower-alkoxy, phenoxy, trifluoromethyl, lower-alkylcarboxy or lower-alkoxycarbonyl; Y is a hydrogen atom or has the meaning given hereinabove for X, and R' is a hydrogen atom or a methyl group.
Claim 2
Dependent Claim
62 words
A compound having the formula: ##STR4## wherein: each R is a hydrogen atom or an X,Y-substituted-benzoyl group, at least one R being an X,Y-substituted-benzoyl group; X is a halogen atom, hydroxy, nitro, lower-alkyl, lower-alkoxy, phenoxy, trifluoromethyl, lower-alkylcarboxy or lower-alkoxycarbonyl; Y is a hydrogen atom or has the meaning given hereinabove for X, and R' is a hydrogen atom or a methyl group.
Claim 3
Dependent Claim
19 words
A compound according to claim 1, wherein each R is an X,Y-substituted-benzoyl group, and R' is a hydrogen atom.
Claim 4
Dependent Claim
14 words
A compound according to claim 1, wherein X or Y is a chlorine atom.
Claim 5
Dependent Claim
14 words
A compound according to claim 1, wherein X or Y is a lower-alkyl group.
Claim 6
Dependent Claim
14 words
A compound according to claim 4, wherein X or Y is a methyl group.
Claim 7
Dependent Claim
14 words
A compound according to claim 1, wherein X or Y is a lower-alkoxy group.
Claim 8
Dependent Claim
14 words
A compound according to claim 6, wherein X or Y is a methoxy group.
Claim 9
Dependent Claim
14 words
A compound according to claim 1, wherein X or Y is a phenoxy group.
Claim 10
Dependent Claim
14 words
A compound according to claim 1 wherein X or Y is a lower-alkylcarboxy group.
Claim 11
Dependent Claim
14 words
A compound according to claim 9, wherein X or Y is a methylcarboxy group.
Claim 12
Dependent Claim
14 words
A compound according to claim 1, wherein X or Y is a lower-alkoxycarbonyl group.
Claim 13
Dependent Claim
14 words
A compound according to claim 11 wherein X or Y is a methoxycarbonyl group.
Claim 14
Dependent Claim
5 words
1,8,9-Tri(2-hydroxybenzoyloxy)anthracene according to claim 2.
Claim 15
Dependent Claim
5 words
1,8,9-Tri(2-acetoxybenzoyloxy)anthracene according to claim 10.
Claim 16
Dependent Claim
5 words
1,8,9-Tri(4-chlorobenzoyloxy)anthracene according to claim 3.
Claim 17
Dependent Claim
5 words
1,8,9-Tri(3-chlorobenzoyloxy)anthracene according to claim 3.
Claim 18
Dependent Claim
5 words
1,8,9-Tri(2-chlorobenzoyloxy)anthracene according to claim 3.
Claim 19
Dependent Claim
5 words
1,8,9-tri(4-methylbenzoyloxy)anthracene according to claim 5.
Claim 20
Dependent Claim
5 words
1,8,9-Tri(3-methylbenzoyloxy)anthracene according to claim 5.
Claim 21
Dependent Claim
5 words
1,8,9-Tri(4-nitrobenzoyloxy)anthracene according to claim 2.
Claim 22
Dependent Claim
5 words
1,8,9-Tri(3-nitrobenzoyloxy)anthracene according to claim 2.
Claim 23
Dependent Claim
5 words
1,8,9-Tri(4-methoxybenzoyloxy)anthracene according to claim 7.
Claim 24
Dependent Claim
5 words
1,8,9-Tri(4-hydroxybenzoyloxy)anthracene according to claim 2.
Claim 25
Dependent Claim
5 words
1,8,9-Tri(2-hydroxybenzoyloxy)-3-methylanthracene according to claim 1.
Claim 26
Dependent Claim
11 words
The mono- or di(2-acetoxybenzoyl) esters of 1,8,9-trihydroxyanthracene according to claim 1.
Claim 27
Dependent Claim
5 words
1,8,9-Tri(2-phenoxybenzoyloxy)anthracene according to claim 8.
Claim 28
Dependent Claim
5 words
1,8,9-Tri[3-trifluoromethyl)benzoyloxy]anthracene according to claim 2.
Claim 29
Dependent Claim
5 words
1,8,9-Tri[4-(methoxycarbonyl)benzoyloxy]anthracene according to claim 12.
Claim 30
Dependent Claim
33 words
A pharmaceutical composition effective in causing the temporary remission of psoriatic lesions which comprises an anti-psoriatic effective amount of an anthracene derivative according to claim 1 in combination with a pharmaceutically acceptable vehicle.
Claim 31
Dependent Claim
23 words
A composition according to claim 29 wherein in the anthracene derivative each R is an X,Y-substitutedbenzoyl group and R' is a hydrogen atom.
Claim 32
Dependent Claim
19 words
A composition according to claim 30 which contains from 0.05 to 10 percent by weight of the anthracene derivative.
Claim 33
Dependent Claim
12 words
A composition according to claim 31 wherein the anthracene derivative is 1,8,9-tri-(2-acetoxybenzoyloxy)anthracene.
Claim 34
Dependent Claim
12 words
A composition according to claim 31 wherein the anthracene derivative is 1,8,9-tri-(2-hydroxybenzoyloxy)anthracene.
Claim 35
Dependent Claim
23 words
A composition according to claim 31 which additionally contains one or two ingredients selected from the group consisting of salicylic acid and hydrocortisone.
Claim 36
Dependent Claim
28 words
A method of treating psoriasis which comprises topically administering to an area of skin having psoriatic lesions a therapeutically effective amount of a composition according to claim 29.
Claim 37
Dependent Claim
28 words
A method of treating psoriasis which comprises topically administering to an area of skin having psoriatic lesions a therapeutically effective amount of a composition according to claim 32.
Claim 38
Dependent Claim
27 words
A method of treating psoriasis which comprises administering to an area of skin having psoriatic lesions a therapeutically effective amount of a composition according to claim 33.
References Cited (Backward Citations)
US1935928A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-02-08 | 1980-08-09 | 1981-02-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-02-08 | 1984-08-09 | 1985-02-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-02-08 | 1988-08-09 | 1989-02-08 | $7700.00 | Window Closed / Lapsed |