US4006232A
Expired / Lapsed
US
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Therapeutic method of treating cardiac arrhythmias utilizing 3-substituted diphenylhydantoins
Assignee: Bayer Corp
•
Filing: 1974-11-15
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Granted: 1977-02-01
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Expires: 1994-11-15
Abstract
Abstract 3-substituted-5,5-diphenylhydantoin derivatives in which the 5,5-diphenylhydantoin moiety is attached at C3 by a loweralkylene bridge to a 4-phenyl-1-piperidyl, 4-hydroxy-4-phenyl-1-piperidyl, 4-phenyl-1,2,3,6-tetrahydropyridyl, 4-phenyl-1-piperazinyl, or loweralkylamino group are useful in the treatment of cardiac arrhythmias in mammals. One or both of the 5,5-diphenyl substituents optionally can be substituted in the ortho-, meta-, or para-positions with halogeno, lowerakyl, loweralkoxy, amino or nitro groups.
Inventors
- 👤 Shin Hayao
- 👤 Herbert John Havera
- 👤 Wallace Glenn Strycker
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 12:05
CPC Classifications
C; C07; C07D; C07D233/00; C07D233/54; C07D233/66; C07D233/72
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
98 words
A method of treating a cardiac arrhythmia in a mammmal which comprises: administering to said mammal an antiarrhythmic effective amount of a compound selected from the group consisting of ##STR8## and a pharmacologically acceptable, nontoxic acid addition salt thereof, wherein: R 1 and R 2 are selected from the group consisting of hydrogen, halogeno, loweralkyl of 1 to 3 carbon atoms, loweralkoxy of 1 to 3 carbon atoms, amino, and nitro; R 3 is selected from the group consisting of ethylene and trimethylene, and R 4 is selected from the group consisting of 4-phenyl-1-piperidyl, 4-hydroxy-4-phenyl-1-piperidyl, 4-phenyl-1,2,3,6-tetrahydropyridyl, and 4-phenyl-1-piperazinyl.
Claim 2
Independent Claim
98 words
A method of treating a cardiac arrhythmia in a mammmal which comprises: administering to said mammal an antiarrhythmic effective amount of a compound selected from the group consisting of ##STR8## and a pharmacologically acceptable, nontoxic acid addition salt thereof, wherein: R 1 and R 2 are selected from the group consisting of hydrogen, halogeno, loweralkyl of 1 to 3 carbon atoms, loweralkoxy of 1 to 3 carbon atoms, amino, and nitro; R 3 is selected from the group consisting of ethylene and trimethylene, and R 4 is selected from the group consisting of 4-phenyl-1-piperidyl, 4-hydroxy-4-phenyl-1-piperidyl, 4-phenyl-1,2,3,6-tetrahydropyridyl, and 4-phenyl-1-piperazinyl.
Claim 3
Dependent Claim
15 words
A method as in claim 1 wherein said amount is from 5 to 500 mg/kg.
Claim 4
Dependent Claim
12 words
A method as in claim 1 wherein the compound is 3-[3-(4-phenyl-1-piperazinyl)propyl]-5,5-diphenylhydantoin maleate.
Claim 5
Dependent Claim
11 words
A method as in claim 1 wherein the compound is 3-[3-(4-phenyl-1-piperidyl)propyl]-5,5-diphenylhydantoin.
Claim 6
Dependent Claim
13 words
A method as in claim 1 wherein the compound is 3-[2-(4-phenyl-1-piperidyl)ethyl]-5,5-diphenylhydantoin .sup.. HCl.
Claim 7
Dependent Claim
14 words
A method as in claim 1 wherein the compound is 5,5-diphenyl-3-[2-(4-phenyl-1,2,3,6-tetrahydropyridyl) ethyl]hydantoin .sup.. HCl.
Claim 8
Dependent Claim
13 words
A method as in claim 1 wherein the compound is 5,5-diphenyl-3-[3-(4-hydroxy-4-phenyl-1-piperidyl)propyl]hydantoin .sup.. HCl.
Claim 9
Dependent Claim
14 words
A method as in claim 1 wherein the compound is 5,5-diphenyl-3-[2-(4-hydroxy-4-phenyl-1-piperidyl)ethyl] hydantoin .sup.. HCl.
Claim 10
Dependent Claim
14 words
A method as in claim 1 wherein the compound is 3-[3-(4-phenyl-1-piperidyl)propyl]-5,5-di(4-chlorophenyl) hydantoin .sup.. HCl.
Claim 11
Dependent Claim
13 words
A method as in claim 1 wherein the compound is 3-[3-(4-phenyl-1-piperidyl)propyl]-5-(4-methoxyphenyl)-5-phenylhydantoin .sup.. HCl.
Claim 12
Dependent Claim
14 words
A method as in claim 1 wherein the compound is 3-[3-(4-phenyl-1-piperidyl)propyl]-5,5-di(4-methoxyphenyl) hydantoin .sup.. HCl.
Claim 13
Dependent Claim
14 words
A method as in claim 1 wherein the compound is 3-[3-(4-phenyl-1-piperidyl)propyl]-5-(4-bromophenyl)-5 -phenylhydantoin .sup.. HCl.
Claim 14
Dependent Claim
14 words
A method as in claim 1 wherein the compound is 3-[3-(4-phenyl-1-piperidyl)propyl]-5-phenyl-5-(4-tolyl) hydantoin .sup.. maleate.
Claim 15
Dependent Claim
11 words
A method as in claim 1 wherein the compound is 3-[3-(4-phenyl-1-piperidyl)propyl)]-5,5-di(4-tolyl)hydantoin.
Claim 16
Dependent Claim
11 words
A method as in claim 1 wherein the compound is 3-[3-(4-phenyl-1-piperidyl)propyl]-5-(4-nitrophenyl)-5-phenylhydantoin.
Claim 17
Dependent Claim
11 words
A method as in claim 1 wherein the compound is 3-[3-(4-phenyl-1-piperidyl)propyl]-5-(4-aminophenyl)-5-phenylhydantoin.
Claim 18
Dependent Claim
11 words
A method as in claim 1 wherein the compound is 3-[3-(4-hydroxy-4-phenyl-1-piperidyl)propyl]-5,5di(4-tolyl)hydantoin.
References Cited (Backward Citations)
US3892748A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-02-01 | 1980-08-02 | 1981-02-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-02-01 | 1984-08-02 | 1985-02-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-02-01 | 1988-08-02 | 1989-02-01 | $7700.00 | Window Closed / Lapsed |