US4005196A
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Vitaminized compositions for treating hypercholesterolemia
Assignee: Procter and Gamble Co
•
Filing: 1976-02-12
•
Granted: 1977-01-25
•
Expires: 1996-02-12
Abstract
Abstract Anti-anal leakage agents are used in combination with vitamin-fortified liquid fatty acid polyester compositions to provide pharmaceutical and food compositions for treating and/or preventing hypercholesterolemia while avoiding undesired anal leakage of the polyesters.
Inventors
- 👤 Ronald James Jandacek
- 👤 Fred Hugh Mattson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 17:43
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/59; A23; A23D; A23D9/00; A23D9/007; A23D9/013; A23L; A23L33/00; A23L33/20; A23L33/21; A23L33/25; A23L33/26; A61K31/70; A61K47/00; A61K47/06; A61K47/26
Claims Analysis
Total Claims: 70
Claim 1
Independent Claim
112 words
A composition of matter, comprising a. an edible, non-absorbable, non-digestible liquid polyol fatty acid polyester having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms; b. sufficient anti-anal leakage agent to prevent leakage of said liquid polyester through the anal sphincter; and c. sufficient fat-soluble vitamin selected from the group consisting of vitamin A, vitamin D, vitamin E and vitamin K to prevent abnormally low levels of any of said fat soluble vitamins in animals ingesting said composition.
Claim 2
Dependent Claim
112 words
A composition of matter, comprising a. an edible, non-absorbable, non-digestible liquid polyol fatty acid polyester having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms; b. sufficient anti-anal leakage agent to prevent leakage of said liquid polyester through the anal sphincter; and c. sufficient fat-soluble vitamin selected from the group consisting of vitamin A, vitamin D, vitamin E and vitamin K to prevent abnormally low levels of any of said fat soluble vitamins in animals ingesting said composition.
Claim 3
Dependent Claim
22 words
A composition according to claim 1 wherein the liquid polyol fatty acid polyester contains no more than about 2 free hydroxyl groups.
Claim 4
Dependent Claim
21 words
A composition according to claim 2 wherein the fatty acid ester groups contain from about 14 to about 18 carbon atoms.
Claim 5
Dependent Claim
24 words
A composition according to claim 3 wherein the polyol is a member selected from the group consisting of erythritol, xylitol, sorbitol, glucose and sucrose.
Claim 6
Dependent Claim
11 words
A composition according to claim 4 wherein the polyol is sucrose.
Claim 7
Dependent Claim
31 words
A composition according to claim 5 wherein the sucrose fatty acid polyester is a member selected from the group consisting of the hexaoleate, heptaoleate and octaoleate of sucrose, and mixtures thereof.
Claim 8
Dependent Claim
108 words
A composition according to claim 1 wherein the anti-anal leakage agent is a member selected from the group consisting of: edible C 12 and higher saturated fatty acids, and their edible salts; edible, digestible sources of C 12 and higher saturated fatty acids; edible, non-absorbable, non-digestible solid polyol fatty acid polyesters having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms; and edible, non-digestible esters of alpha-branched chain C 10 -C 18 fatty acids.
Claim 9
Dependent Claim
19 words
A composition according to claim 7 which comprises at least about 10% by weight of the anti-anal leakage agent.
Claim 10
Dependent Claim
19 words
A composition according to claim 7 which comprises at least about 20% by weight of the anti-anal leakage agent.
Claim 11
Dependent Claim
21 words
A composition according to claim 7 which comprises from about 20% to about 50% by weight of the anti-anal leakage agent.
Claim 12
Dependent Claim
46 words
A composition according to claim 7 which comprises from about 10% to about 50% by weight of an anti-anal leakage agent selected from the group consisting of edible C 12 -C 24 saturated fatty acids and edible salts of C 12 -C 24 saturated fatty acids.
Claim 13
Dependent Claim
41 words
A composition according to claim 7 which comprises from about 10% to about 50% by weight of an anti-anal leakage agent selected from the group consisting of edible, digestible sources of C 12 -C 24 saturated fatty acids, and mixtures thereof.
Claim 14
Dependent Claim
27 words
A composition according to claim 12 wherein the anti-anal leakage agent is a lower alkyl ester of C 12 -C 24 saturated fatty acids, or mixtures thereof.
Claim 15
Dependent Claim
26 words
A composition according to claim 12 wherein the anti-anal leakage agent comprises substantially saturated triglyceride esters of C 12 -C 24 fatty acids, or mixtures thereof.
Claim 16
Dependent Claim
15 words
A composition according to claim 14 wherein the anti-anal leakage agent is hydrogenated palm oil.
Claim 17
Dependent Claim
17 words
A composition according to claim 14 wherein the anti-anal leakage agent is natural or synthetic cocoa butter.
Claim 18
Dependent Claim
48 words
A composition according to claim 14 wherein the anti-anal leakage agent is an edible position-specific trigylceride selected from the group consisting of: the 1-stearoyl, 1-palmitoyl, 1-arachidoyl and 1-behenoyl 2,3-dioleins; the 2-oleoyl 1,3-distearins, 1,3-dipalmitins, 1,3-diarachidins and 1,3-dibehenins; 1-oleoyl distearin; 1-palmitoyl distearin; 1-arachidoyl distearin; and 1-behenoyl distearin; and mixtures thereof.
Claim 19
Dependent Claim
20 words
A composition according to claim 17 which comprises from about 20% to about 40% by weight of the position-specific triglyceride.
Claim 20
Dependent Claim
79 words
A composition according to claim 7 which comprises from about 20% to about 50% by weight of an anti-anal leakage agent selected from the group consisting of edible, non-absorbable, non-digestible solid polyol fatty acid polyesters having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms.
Claim 21
Dependent Claim
27 words
A composition according to claim 19 wherein the anti-anal leakage agent is selected from the group consisting of C 10 -C 22 saturated fatty acid polyol esters.
Claim 22
Dependent Claim
65 words
A composition according to claim 1 which comprises from about 50% to about 90% by weight of the non-absorbable, non-digestible liquid polyol fatty acid polyester, at least about 10% by weight of the anti-anal leakage agent, and from about 0.001% to about 2% by weight of a vitamin selected from the group consisting of vitamin A, vitamin D, vitamin E, vitamin K, and mixtures thereof.
Claim 23
Independent Claim
147 words
A method for inhibiting the absorption of cholesterol without decreasing the body's stores of fat-soluble vitamins or causing an anal leakage effect comprising systemically administering to an animal susceptible to or afflicted with hypercholesterolemia successive therapeutically effective doses of a composition comprising a non-absorbable, non-digestible liquid polyol fatty acid polyester having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms; sufficient anti-anal leakage agent to prevent leakage of said liquid polyester through the anal sphincter; and sufficient fat-soluble vitamin selected from the group consisting of vitamin A, vitamin D, vitamin E and vitamin K, and mixtures thereof, to prevent abnormally low levels of any of said fat-soluble vitamins in animals ingesting said composition.
Claim 24
Independent Claim
147 words
A method for inhibiting the absorption of cholesterol without decreasing the body's stores of fat-soluble vitamins or causing an anal leakage effect comprising systemically administering to an animal susceptible to or afflicted with hypercholesterolemia successive therapeutically effective doses of a composition comprising a non-absorbable, non-digestible liquid polyol fatty acid polyester having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms; sufficient anti-anal leakage agent to prevent leakage of said liquid polyester through the anal sphincter; and sufficient fat-soluble vitamin selected from the group consisting of vitamin A, vitamin D, vitamin E and vitamin K, and mixtures thereof, to prevent abnormally low levels of any of said fat-soluble vitamins in animals ingesting said composition.
Claim 25
Dependent Claim
108 words
A method according to claim 22 wherein the anti-anal leakage agent is a member selected from the group consisting of: edible C 12 -C 24 saturated fatty acids, and their edible salts; edible, digestible sources of C 12 -C 24 saturated fatty acids; edible, nonabsorbable, non-digestible solid polyol fatty acid polyesters having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms; and edible, non-digestible esters of alpha-branched chain C 10 -C 18 fatty acids.
Claim 26
Dependent Claim
21 words
A method according to claim 23 wherein the composition comprises at least about 10% by weight of the anti-anal leakage agent.
Claim 27
Dependent Claim
21 words
A method according to claim 23 wherein the composition comprises at least about 20% by weight of the anti-anal leakage agent.
Claim 28
Dependent Claim
152 words
A low calorie fat-containing food composition comprising non-fat ingredients and fat ingredients, wherein from about 10% to about 100% of the total fat ingredients comprise: a. a portion comprising an edible, non-absorbable, non-digestible liquid polyol fatty acid polyester having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms; and b. sufficient anti-anal leakage agent to prevent leakage of said liquid polyester through the anal sphincter, said food composition being fortified with sufficient fat-soluble vitamin selected from the group consisting of vitamin A, vitamin D, vitamin E and vitamin K, or mixtures thereof, over and above that naturally present in said food composition, to prevent abnormally low levels of any of said fat-soluble vitamins in animals ingesting said composition.
Claim 29
Dependent Claim
152 words
A low calorie fat-containing food composition comprising non-fat ingredients and fat ingredients, wherein from about 10% to about 100% of the total fat ingredients comprise: a. a portion comprising an edible, non-absorbable, non-digestible liquid polyol fatty acid polyester having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms; and b. sufficient anti-anal leakage agent to prevent leakage of said liquid polyester through the anal sphincter, said food composition being fortified with sufficient fat-soluble vitamin selected from the group consisting of vitamin A, vitamin D, vitamin E and vitamin K, or mixtures thereof, over and above that naturally present in said food composition, to prevent abnormally low levels of any of said fat-soluble vitamins in animals ingesting said composition.
Claim 30
Dependent Claim
22 words
A composition according to claim 26 wherein the liquid polyol fatty acid polyester contains no more than about 2 free hydroxyl groups.
Claim 31
Dependent Claim
21 words
A composition according to claim 27 wherein the fatty acid ester groups contain from about 14 to about 18 carbon atoms.
Claim 32
Dependent Claim
24 words
A composition according to claim 28 wherein the polyol is a member selected from the group consisting of erythritol, xylitol, sorbitol, glucose and sucrose.
Claim 33
Dependent Claim
11 words
A composition according to claim 29 wherein the polyol is sucrose.
Claim 34
Dependent Claim
31 words
A composition according to claim 30 wherein the sucrose fatty acid polyester is a member selected from the group consisting of the hexaoleate, heptaoleate and octaoleate of sucrose, and mixtures thereof.
Claim 35
Dependent Claim
108 words
A composition according to claim 31 wherein the anti-anal leakage agent is a member selected from the group consisting of: edible C 12 and higher saturated fatty acids, and their edible salts; edible, digestible sources of C 12 and higher saturated fatty acids; edible, non-absorbable, non-digestible solid polyol fatty acid polyesters having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms; and edible, non-digestible esters of alpha-branched chain C 10 -C 18 fatty acids.
Claim 36
Dependent Claim
27 words
A composition according to claim 26 wherein the liquid polyester portion of the fat ingredients comprises at least about 10% by weight of the anti-anal leakage agent.
Claim 37
Dependent Claim
27 words
A composition according to claim 33 wherein the liquid polyester portion of the fat ingredients comprises at least about 20% by weight of the anti-anal leakge agent.
Claim 38
Dependent Claim
29 words
A composition according to claim 34 wherein the liquid polyester portion of the fat ingredients comprises from about 20% to about 50% by weight of the anti-anal leakage agent.
Claim 39
Dependent Claim
53 words
A composition according to claim 32 wherein the liquid polyester portion of the fat ingredients comprises from about 10% to about 50% by weight of an anti-anal leakage agent selected from the group consisting of edible, digestible C 12 -C 24 fatty acids and edible salts of C 12 -C 24 fatty acids.
Claim 40
Dependent Claim
49 words
A composition according to claim 32 wherein the liquid polyester portion of the fat ingredients comprises from about 10% to about 50% by weight of an anti-anal leakage agent selected from the group consisting of edible, digestible sources of C 12 -C 24 saturated fatty acids, and mixtures thereof.
Claim 41
Dependent Claim
27 words
A composition according to claim 37 wherein the anti-anal leakage agent is a lower alkyl ester of C 12 -C 24 saturated fatty acids, or mixtures thereof.
Claim 42
Dependent Claim
26 words
A composition according to claim 37 wherein the anti-anal leakage agent comprises substantially saturated triglyceride esters of C 12 -C 24 fatty acids, or mixtures thereof.
Claim 43
Dependent Claim
15 words
A composition according to claim 39 wherein the anti-anal leakge agent is hydrogenated palm oil.
Claim 44
Dependent Claim
17 words
A composition according to claim 39 wherein the anti-anal leakage agent is natural or synthetic cocoa butter.
Claim 45
Dependent Claim
48 words
A composition according to claim 39 wherein the anti-anal leakage agent is an edible position-specific triglyceride selected from the group consisting of: the 1-stearoyl, 1-palmitoyl, 1-arachidoyl and 1-behenoyl 2,3-dioleins; the 2-oleoyl 1,3-distearins, 1,3-dipalmitins, 1,3-diarachidins and 1,3-dibehenins; 1-oleoyl distearin; 1-palmitoyl distearin; 1-arachidoyl distearin; and 1-behenoyl distearin; and mixtures thereof.
Claim 46
Dependent Claim
28 words
A composition according to claim 42 wherein the liquid polyester portion of the fat ingredients comprises from about 20% to about 40% by weight of the position-specific triglyceride.
Claim 47
Dependent Claim
87 words
A composition according to claim 32 wherein the liquid polyester portion of the fat ingredients comprises from about 20% to about 50% by weight of an anti-anal leakage agent selected from the group consisting of edible, non-absorbable, non-digestible solid polyol fatty acid polyesters having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms.
Claim 48
Dependent Claim
27 words
A composition according to claim 44 wherein the anti-anal leakage agent is selected from the group consisting of C 10 -C 22 saturated fatty acid polyol esters.
Claim 49
Dependent Claim
145 words
A pharmaceutical composition in effective unit dosage amounts for inhibiting the absorption of cholesterol without causing an anal leakage effect or interfering with the body's stores of fat-soluble vitamins, comprising: a. from about 0.1 gram to about 5 grams of an edible, non-absorbable, non-digestible liquid polyol fatty acid polyester having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms; b. sufficient anti-anal leakage agent to prevent leakage of said liquid polyester through the anal sphincter; and c. sufficient fat-soluble vitamin selected from the group consisting of vitamin A, vitamin D, vitamin E and vitamin K to prevent abnormally low levels of any of said fat-soluble vitamins in animals ingesting said composition.
Claim 50
Dependent Claim
145 words
A pharmaceutical composition in effective unit dosage amounts for inhibiting the absorption of cholesterol without causing an anal leakage effect or interfering with the body's stores of fat-soluble vitamins, comprising: a. from about 0.1 gram to about 5 grams of an edible, non-absorbable, non-digestible liquid polyol fatty acid polyester having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms; b. sufficient anti-anal leakage agent to prevent leakage of said liquid polyester through the anal sphincter; and c. sufficient fat-soluble vitamin selected from the group consisting of vitamin A, vitamin D, vitamin E and vitamin K to prevent abnormally low levels of any of said fat-soluble vitamins in animals ingesting said composition.
Claim 51
Dependent Claim
22 words
A composition according to claim 46 wherein the liquid polyol fatty acid polyester contains no more than about 2 free hydroxyl groups.
Claim 52
Dependent Claim
21 words
A composition according to claim 47 wherein the fatty acid ester groups contain from about 14 to about 18 carbon atoms.
Claim 53
Dependent Claim
24 words
A composition according to claim 48 wherein the polyol is a member selected from the group consisting of erythritol, xylitol, sorbitol, glucose and sucrose.
Claim 54
Dependent Claim
11 words
A composition according to claim 49 wherein the polyol is sucrose.
Claim 55
Dependent Claim
31 words
A composition according to claim 50 wherein the sucrose fatty acid polyester is a member selected from the group consisting of the hexaoleate, heptaoleate and octaoleate of sucrose, and mixtures thereof.
Claim 56
Dependent Claim
108 words
A composition according to claim 46 wherein the anti-anal leakage agent is a member selected from the group consisting of: edible C 12 and higher saturated fatty acids, and their edible salts; edible, digestible sources of C 12 and higher saturated fatty acids; edible, non-absorbable, non-digestible solid polyol fatty acid polyesters having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms; and edible, non-digestible esters of alpha-branched chain C 10 -C 18 fatty acids.
Claim 57
Dependent Claim
19 words
A composition according to claim 52 which comprises at least about 10% by weight of the anti-anal leakage agent.
Claim 58
Dependent Claim
19 words
A composition according to claim 52 which comprises at least about 20% by weight of the anti-anal leakage agent.
Claim 59
Dependent Claim
21 words
A composition according to claim 52 which comprises from about 20% to about 50% by weight of the anti-anal leakage agent.
Claim 60
Dependent Claim
45 words
A composition according to claim 52 which comprises from about 10% to about 50% by weight of an anti-anal leakage agent selected from the group consisting of edible C 12 -C 24 saturated fatty acids and edible salts of C 12 -C 24 fatty acids.
Claim 61
Dependent Claim
41 words
A composition according to claim 52 which comprises from about 10% to about 50% by weight of an anti-anal leakage agent selected from the group consisting of edible, digestible sources of C 12 -C 24 saturated fatty acids, and mixtures thereof.
Claim 62
Dependent Claim
27 words
A composition according to claim 57 wherein the anti-anal leakage agent is a lower alkyl ester of C 12 -C 24 saturated fatty acids, or mixtures thereof.
Claim 63
Dependent Claim
26 words
A composition according to claim 57 wherein the anti-anal leakage agent comprises substantially saturated triglyceride esters of C 12 -C 24 fatty acids, or mixtures thereof.
Claim 64
Dependent Claim
15 words
A composition according to claim 59 wherein the anti-anal leakage agent is hydrogenated palm oil.
Claim 65
Dependent Claim
17 words
A composition according to claim 59 wherein the anti-anal leakage agent is natural or synthetic cocoa butter.
Claim 66
Dependent Claim
48 words
A composition according to claim 59 wherein the anti-anal leakage agent is an edible position-specific triglyceride selected from the group consisting of: the 1-stearoly, 1-palmitoyl, 1-arachidoyl and 1-benhenoyl 2,3-dioleins; the 2-oleoyl 1,3-distearins, 1,3-dipalmitins, 1,3-diarachidins and 1,3-dibehenins; 1-oleoyl distearin; 1-palmitoyl distearin; 1-arachidoyl distearin; and 1-behenoyl distearin; and mixtures thereof.
Claim 67
Dependent Claim
20 words
A composition according to claim 62 which comprises from about 20% to about 40% by weight of the position-specific triglyceride.
Claim 68
Dependent Claim
79 words
A composition according to claim 52 which comprises from about 20% to about 50% by weight of an anti-anal leakage agent selected from the group consisting of edible, non-absorbable, non-digestible solid polyol fatty acid polyesters having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms.
Claim 69
Dependent Claim
27 words
A composition according to claim 64 wherein the anti-anal leakage agent is selected from the group consisting of C 10 -C 22 saturated fatty acid polyol esters.
Claim 70
Dependent Claim
36 words
A composition in accordance with claim 46 which contains at least about 0.1 RDA of a vitamin selected from the group consisting of vitamin A, vitamin D, vitamin E, vitamin K, and mixtures of said vitamins.
References Cited (Backward Citations)
US3954976A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-01-25 | 1980-07-26 | 1981-01-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-01-25 | 1984-07-26 | 1985-01-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-01-25 | 1988-07-26 | 1989-01-25 | $7700.00 | Window Closed / Lapsed |