US4005195A
Expired / Lapsed
US
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Compositions for treating hypercholesterolemia
Assignee: Procter and Gamble Co
•
Filing: 1976-02-12
•
Granted: 1977-01-25
•
Expires: 1996-02-12
Abstract
Abstract Anti-anal leakage agents are used in combination with liquid polyol fatty acid polyesters to provide pharmaceutical and food compositions for treating and/or preventing hypercholesterolemia while avoiding undesired anal leakage of the liquid polyesters.
Inventors
- 👤 Ronald James Jandacek
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 23:11
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/21; A61K31/215; A61K31/22; A61K31/23; A23; A23D; A23D9/00; A23D9/007; A23D9/013; A23L; A23L33/00; A23L33/20; A23L33/21; A23L33/25; A23L33/26; A61K31/70
Claims Analysis
Total Claims: 68
Claim 1
Independent Claim
76 words
A composition of matter, comprising: a. an edible, non-absorbable, non-digestible liquid polyol fatty acid polyester having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms; and b. sufficient anti-anal leakage agent to prevent leakage of said liquid polyester through the anal sphincter.
Claim 2
Dependent Claim
76 words
A composition of matter, comprising: a. an edible, non-absorbable, non-digestible liquid polyol fatty acid polyester having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms; and b. sufficient anti-anal leakage agent to prevent leakage of said liquid polyester through the anal sphincter.
Claim 3
Dependent Claim
22 words
A composition according to claim 1 wherein the liquid polyol fatty acid polyester contains no more than about 2 free hydroxyl groups.
Claim 4
Dependent Claim
21 words
A composition according to claim 2 wherein the fatty acid ester groups contain from about 14 to about 18 carbon atoms.
Claim 5
Dependent Claim
24 words
A composition according to claim 3 wherein the polyol is a member selected from the group consisting of erythritol, xylitol, sorbitol, glucose and sucrose.
Claim 6
Dependent Claim
11 words
A composition according to claim 4 wherein the polyol is sucrose.
Claim 7
Dependent Claim
31 words
A composition according to claim 5 wherein the sucrose fatty acid polyester is a member selected from the group consisting of the hexaoleate, heptaoleate and octaoleate of sucrose, and mixtures thereof.
Claim 8
Dependent Claim
108 words
A composition according to claim 1 wherein the anti-anal leakage agent is a member selected from the group consisting of: edible C 12 and higher saturated fatty acids, and their edible salts; edible, digestible sources of C 12 and higher saturated fatty acids; edible, non-absorbable, non-digestible solid polyol fatty acid polyesters having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms; and edible, non-digestible esters of alpha-branched chain C 10 -C 18 fatty acids.
Claim 9
Dependent Claim
19 words
A composition according to claim 7 which comprises at least about 10% by weight of the anti-anal leakage agent.
Claim 10
Dependent Claim
19 words
A composition according to claim 7 which comprises at least about 20% by weight of the anti-anal leakage agent.
Claim 11
Dependent Claim
21 words
A composition according to claim 7 which comprises from about 20% to about 50% by weight of the anti-anal leakage agent.
Claim 12
Dependent Claim
46 words
A composition according to claim 7 which comprises from about 10% to about 50% by weight of an anti-anal leakage agent selected from the group consisting of edible C 12 -C 24 saturated fatty acids and edible salts of C 12 -C 24 saturated fatty acids.
Claim 13
Dependent Claim
41 words
A composition according to claim 7 which comprises from about 10% to about 50% by weight of an anti-anal leakage agent selected from the group consisting of edible, digestible sources of C 12 -C 24 saturated fatty acids, and mixtures thereof.
Claim 14
Dependent Claim
27 words
A composition according to claim 12 wherein the anti-anal leakage agent is a lower alkyl ester of C 12 -C 24 saturated fatty acids, or mixtures thereof.
Claim 15
Dependent Claim
26 words
A composition according to claim 12 wherein the anti-anal leakage agent comprises substantially saturated triglyceride esters of C 12 -C 24 fatty acids, or mixtures thereof.
Claim 16
Dependent Claim
15 words
A composition according to claim 14 wherein the anti-anal leakage agent is hydrogenated palm oil.
Claim 17
Dependent Claim
17 words
A composition according to claim 14 wherein the anti-anal leakage agent is natural or synthetic cocoa butter.
Claim 18
Dependent Claim
48 words
A composition according to claim 14 wherein the anti-anal leakage agent is an edible position-specific triglyceride selected from the group consisting of: the 1-stearoyl, 1-palmitoyl, 1-arachidoyl and 1-behenoyl 2,3-dioleins; the 2-oleoyl 1,3-distearins, 1,3-dipalmitins, 1,3-diarachidins and 1,3-dibehenins; 1-oleoyl distearin; 1-palmitoyl distearin; 1-arachidoyl distearin; and 1-behenoyl distearin; and mixtures thereof.
Claim 19
Dependent Claim
20 words
A composition according to claim 17 which comprises from about 20% to about 40% by weight of the position-specific triglyceride.
Claim 20
Dependent Claim
79 words
A composition according to claim 7 which comprises from about 20% to about 50% by weight of an anti-anal leakage agent selected from the group consisting of edible, non-absorbable, non-digestible solid polyol fatty acid polyesters having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms.
Claim 21
Dependent Claim
27 words
A composition according to claim 19 wherein the anti-anal leakage agent is selected from the group consisting of C 10 -C 22 saturated fatty acid polyol esters.
Claim 22
Independent Claim
104 words
A method for inhibiting the absorption of cholesterol in animals without causing an anal leakage effect comprising systemically administering to an animal susceptible to or afflicted with hypercholesterolemia successive therapeutically effective doses of a composition comprising: a non-absorbable, non-digestible liquid polyol fatty acid polyester having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms and sufficient anti-anal leakage agent to prevent leakage of said liquid polyester through the anal sphincter.
Claim 23
Independent Claim
104 words
A method for inhibiting the absorption of cholesterol in animals without causing an anal leakage effect comprising systemically administering to an animal susceptible to or afflicted with hypercholesterolemia successive therapeutically effective doses of a composition comprising: a non-absorbable, non-digestible liquid polyol fatty acid polyester having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms and sufficient anti-anal leakage agent to prevent leakage of said liquid polyester through the anal sphincter.
Claim 24
Dependent Claim
108 words
A method according to claim 21 wherein the anti-anal leakage agent is a member selected from the group consisting of: edible C 12 -C 24 saturated fatty acids, and their edible salts; edible, digestible sources of C 12 -C 24 saturated fatty acids; edible, non-absorbable, non-digestible solid polyol fatty acid polyesters having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms; and edible, non-digestible esters of alpha-branched chain C 10 -C 18 fatty acids.
Claim 25
Dependent Claim
21 words
A method according to claim 22 wherein the composition comprises at least about 10% by weight of the anti-anal leakage agent.
Claim 26
Dependent Claim
21 words
A method according to claim 23 wherein the composition comprises at least about 20% by weight of the anti-anal leakage agent.
Claim 27
Dependent Claim
99 words
A low calorie fat-containing food composition comprising non-fat ingredients and fat ingredients, wherein from about 10% to about 100% of the total fat ingredients comprise: a. a portion comprising an edible, non-absorbable, non-digestible liquid polyol fatty acid polyester having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms; and b. sufficient anti-anal leakage agent to prevent leakage of said liquid polyester through the anal sphincter.
Claim 28
Dependent Claim
99 words
A low calorie fat-containing food composition comprising non-fat ingredients and fat ingredients, wherein from about 10% to about 100% of the total fat ingredients comprise: a. a portion comprising an edible, non-absorbable, non-digestible liquid polyol fatty acid polyester having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms; and b. sufficient anti-anal leakage agent to prevent leakage of said liquid polyester through the anal sphincter.
Claim 29
Dependent Claim
22 words
A composition according to claim 25 wherein the liquid polyol fatty acid polyester contains no more than about 2 free hydroxyl groups.
Claim 30
Dependent Claim
21 words
A composition according to claim 26 wherein the fatty acid ester groups contain from about 14 to about 18 carbon atoms.
Claim 31
Dependent Claim
24 words
A composition according to claim 27 wherein the polyol is a member selected from the group consisting of erythritol, xylitol, sorbitol, glucose and sucrose.
Claim 32
Dependent Claim
11 words
A composition according to claim 28 wherein the polyol is sucrose.
Claim 33
Dependent Claim
31 words
A composition according to claim 29 wherein the sucrose fatty acid polyester is a member selected from the group consisting of the hexaoleate, heptaoleate and octaoleate of sucrose, and mixtures thereof.
Claim 34
Dependent Claim
108 words
A composition according to claim 25 wherein the anti-anal leakage agent is a member selected from the group consisting of: edible C 12 and higher saturated fatty acids, and their edible salts; edible, digestible sources of C 12 and higher saturated fatty acids; edible, non-absorbable, non-digestible solid polyol fatty acid polyesters having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms; and edible, non-digestible esters of alpha-branched chain C 10 -C 18 fatty acids.
Claim 35
Dependent Claim
27 words
A composition according to claim 31 wherein the liquid polyester portion of the fat ingredients comprises at least about 10% by weight of the anti-anal leakage agent.
Claim 36
Dependent Claim
27 words
A composition according to claim 32 wherein the liquid polyester portion of the fat ingredients comprises at least about 20% by weight of the anti-anal leakage agent.
Claim 37
Dependent Claim
29 words
A composition according to claim 33 wherein the liquid polyester portion of the fat ingredients comprises from about 20% to about 50% by weight of the anti-anal leakage agent.
Claim 38
Dependent Claim
53 words
A composition according to claim 31 wherein the liquid polyester portion of the fat ingredients comprises from about 10% to about 50% by weight of an anti-anal leakage agent selected from the group consisting of edible C 12 -C 24 saturated fatty acids and edible salts of C 12 -C 24 fatty acids.
Claim 39
Dependent Claim
49 words
A composition according to claim 31 wherein the liquid polyester portion of the fat ingredients comprises from about 10% to about 50% by weight of an anti-anal leakage agent selected from the group consisting of edible, digestible sources of C 12 -C 24 saturated fatty acids, and mixtures thereof.
Claim 40
Dependent Claim
27 words
A composition according to claim 36 wherein the anti-anal leakage agent is a lower alkyl ester of C 12 -C 24 saturated fatty acids, or mixtures thereof.
Claim 41
Dependent Claim
26 words
A composition according to claim 36 wherein the anti-anal leakage agent comprises substantially saturated triglyceride esters of C 12 -C 24 fatty acids, or mixtures thereof.
Claim 42
Dependent Claim
15 words
A composition according to claim 38 wherein the anti-anal leakage agent is hydrogenated palm oil.
Claim 43
Dependent Claim
17 words
A composition according to claim 38 wherein the anti-anal leakage agent is natural or synthetic cocoa butter.
Claim 44
Dependent Claim
48 words
A composition according to claim 38 wherein the anti-anal leakage agent is an edible position-specific triglyceride selected from the group consisting of: the 1-stearoyl, 1-palmitoyl, 1-arachidoyl and 1-behenoyl 2,3-dioleins; the 2-oleoyl 1,3-distearins, 1,3-dipalmitins, 1,3-diarachidins and 1,3-dibehenins; 1-oleoyl distearin; 1-palmitoyl distearin; 1-arachidoyl distearin; and 1-behenoyl distearin; and mixtures thereof.
Claim 45
Dependent Claim
28 words
A composition according to claim 41 wherein the liquid polyester portion of the fat ingredients comprises from about 20% to about 40% by weight of the position-specific triglyceride.
Claim 46
Dependent Claim
87 words
A composition according to claim 31 wherein the liquid polyester portion of the fat ingredients comprises from about 20% to about 50% by weight of an anti-anal leakage agent selected from the group consisting of edible, non-absorbable, non-digestible solid polyol fatty acid polyesters having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms.
Claim 47
Dependent Claim
27 words
A composition according to claim 43 wherein the anti-anal leakage agent is selected from the group consisting of C 10 -C 22 saturated fatty acid polyol esters.
Claim 48
Dependent Claim
101 words
A pharmaceutical composition in effective unit dosage amounts for inhibiting the absorption of cholesterol without causing an anal leakage effect, comprising: a. from about 0.1 gram to about 5 grams of an edible, non-absorbable, non-digestible liquid polyol fatty acid polyester having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms; and b. sufficient anti-anal leakage agent to prevent leakage of said liquid polyester through the anal sphincter.
Claim 49
Dependent Claim
101 words
A pharmaceutical composition in effective unit dosage amounts for inhibiting the absorption of cholesterol without causing an anal leakage effect, comprising: a. from about 0.1 gram to about 5 grams of an edible, non-absorbable, non-digestible liquid polyol fatty acid polyester having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms; and b. sufficient anti-anal leakage agent to prevent leakage of said liquid polyester through the anal sphincter.
Claim 50
Dependent Claim
22 words
A composition according to claim 45 wherein the liquid polyol fatty acid polyester contains no more than about 2 free hydroxyl groups.
Claim 51
Dependent Claim
21 words
A composition according to claim 46 wherein the fatty acid ester groups contain from about 14 to about 18 carbon atoms.
Claim 52
Dependent Claim
24 words
A composition according to claim 47 wherein the polyol is a member selected from the group consisting of erythritol, xylitol, sorbitol, glucose and sucrose.
Claim 53
Dependent Claim
11 words
A composition according to claim 48 wherein the polyol is sucrose.
Claim 54
Dependent Claim
31 words
A composition according to claim 49 wherein the sucrose fatty acid polyester is a member selected from the group consisting of the hexaoleate, heptaoleate and octaoleate of sucrose, and mixtures thereof.
Claim 55
Dependent Claim
108 words
A composition according to claim 45 wherein the anti-anal leakage agent is a member selected from the group consisting of: edible C 12 and higher saturated fatty acids, and their edible salts; edible, digestible sources of C 12 and higher saturated fatty acids; edible, non-absorbable, non-digestible solid polyol fatty acid polyesters having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms; and edible, non-digestible esters of alpha-branched chain C 10 -C 18 fatty acids.
Claim 56
Dependent Claim
19 words
A composition according to claim 51 which comprises at least about 10% by weight of the anti-anal leakage agent.
Claim 57
Dependent Claim
19 words
A composition according to claim 51 which comprises at least about 20% by weight of the anti-anal leakage agent.
Claim 58
Dependent Claim
21 words
A composition according to claim 51 which comprises from about 20% to about 50% by weight of the anti-anal leakage agent.
Claim 59
Dependent Claim
45 words
A composition according to claim 51 which comprises from about 10% to about 50% by weight of an anti-anal leakage agent selected from the group consisting of edible C 12 -C 24 saturated fatty acids and edible salts of C 12 -C 24 fatty acids.
Claim 60
Dependent Claim
41 words
A composition according to claim 51 which comprises from about 10% to about 50% by weight of an anti-anal leakage agent selected from the group consisting of edible, digestible sources of C 12 -C 24 saturated fatty acids, and mixtures thereof.
Claim 61
Dependent Claim
27 words
A composition according to claim 56 wherein the anti-anal leakage agent is a lower alkyl ester of C 12 -C 24 saturated fatty acids, or mixtures thereof.
Claim 62
Dependent Claim
26 words
A composition according to claim 56 wherein the anti-anal leakage agent comprises substantially saturated triglyceride esters of C 12 -C 24 fatty acids, or mixtures thereof.
Claim 63
Dependent Claim
15 words
A composition according to claim 58 wherein the anti-anal leakage agent is hydrogenated palm oil.
Claim 64
Dependent Claim
17 words
A composition according to claim 58 wherein the anti-anal leakage agent is natural or synthetic cocoa butter.
Claim 65
Dependent Claim
48 words
A composition according to claim 58 wherein the anti-anal leakage agent is an edible position-specific triglyceride selected from the group consisting of: the 1-stearoyl, 1-palmitoyl, 1-arachidoyl and 1-behenoyl 2,3-dioleins; the 2-oleoyl 1,3-distearins, 1,3-dipalmitins, 1,3-diarachidins and 1,3-dibehenins; 1-oleoyl distearin; 1-palmitoyl distearin; 1-arachidoyl distearin; and 1-behenoyl distearin; and mixtures thereof.
Claim 66
Dependent Claim
20 words
A composition according to claim 61 which comprises from about 20% to about 40% by weight of the position-specific triglyceride.
Claim 67
Dependent Claim
79 words
A composition according to claim 51 which comprises from about 20% to about 50% by weight of an anti-anal leakage agent selected from the group consisting of edible, non-absorbable, non-digestible solid polyol fatty acid polyesters having at least 4 fatty acid ester groups, wherein the polyol is selected from the group consisting of sugars and sugar alcohols containing from 4 to 8 hydroxyl groups and wherein each fatty acid group has from about 8 to about 22 carbon atoms.
Claim 68
Dependent Claim
27 words
A composition according to claim 63 wherein the anti-anal leakage agent is selected from the group consisting of C 10 -C 22 saturated fatty acid polyol esters.
References Cited (Backward Citations)
US3954976A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-01-25 | 1980-07-26 | 1981-01-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-01-25 | 1984-07-26 | 1985-01-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-01-25 | 1988-07-26 | 1989-01-25 | $7700.00 | Window Closed / Lapsed |