US4005089A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Compounds with ergoline skeleton
Assignee: Richter Gedeon Vegyeszeti Gyar Nyrt
•
Filing: 1975-05-22
•
Granted: 1977-01-25
•
Expires: 1995-05-22
Abstract
Abstract New compounds of the general formula (I) <IMAGE> (I) wherein R stands for hydrogen or methyl group, X Y STANDS FOR A GROUP OF THE FORMULA <IMAGE> and R1 stands for a group of the formula (III), (IV) or (V) <IMAGE> (III) <IMAGE> (IV) <IMAGE> (V) wherein n is an integer from 4 to 10, ARE PREPARED BY ACYLATING A COMPOUND OF THE GENERAL FORMULA (II), <IMAGE> (II) wherein R and x y each have the same meanings as defined above, and R2 stands for a group of the formula (VI), (VII) or (VIII), <IMAGE> (VI) <IMAGE> (VII) <IMAGE> (VIII) with a C6-12 carboxylic acid or a C6-12 carboxylic acid halide.
Inventors
- 👤 Erzsebet Mago nee Karacsony
- 👤 Jozsef Borsi
- 👤 Endre Csanyi
- 👤 Katalin Pik
- 👤 Lajos Wolf
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 04:09
CPC Classifications
C; C07; C07D; C07D457/00; C07D457/04; C07D457/06; A; A61; A61P; A61P25/00; A61P25/24; A61P25/26; A61P43/00; C07D457/02
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
36 words
A compound of the formula ##STR16##wherein R is hydrogen or methyl, x y is ##STR17##and R 1 is ##STR18##wherein n is an integer of from 4 to 10, or a pharmaceutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
36 words
A compound of the formula ##STR16##wherein R is hydrogen or methyl, x y is ##STR17##and R 1 is ##STR18##wherein n is an integer of from 4 to 10, or a pharmaceutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
10 words
1-Methyl-dihydrolysergyl-nitroargininole decanoate or a pharmaceutically acceptable acid addition salt thereof.
Claim 4
Dependent Claim
10 words
1-Methyl-dihydrolysergyl-nitroargininole decanoate or a pharmaceutically acceptable acid addition salt thereof.
Claim 5
Dependent Claim
14 words
A compound as claimed in claim 1, in which n is equal to 8.
Claim 6
Dependent Claim
39 words
A pharmaceutical composition having a prolonged antiserotonine effect containing as active ingredient a compound as in claim 1 in the amount of 10 to 200 mg per unit dosage, together with a pharmaceutically acceptable carrier, diluent and/or auxiliary agent.
Claim 7
Dependent Claim
36 words
A process for the preparation of a pharmaceutical composition, in which a compound as claimed in claim 1 is converted into a pharmaceutical composition by admixing it with a pharmaceutically acceptable carrier, diluent and/or auxiliary agent.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-01-25 | 1980-07-26 | 1981-01-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-01-25 | 1984-07-26 | 1985-01-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-01-25 | 1988-07-26 | 1989-01-25 | $7700.00 | Window Closed / Lapsed |