US4004451A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Automated timing of fluid delivery in sample analysis
Assignee: Bayer Corp
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Filing: 1974-12-24
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Granted: 1977-01-25
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Expires: 1994-12-24
Abstract
Abstract Apparatus and method for analyzing liquid sample comprising flowing a stream including a liquid continuously in a conduit, detecting a flow rate characteristic in the conduit and generating a signal in response thereto, and increasing, decreasing or maintaining, unchanged the flow rate of the stream in the conduit in response to the signal, the flow being increased or decreased by the flow into the conduit of another fluid without changing the concentration of the aforementioned liquid. The continuing flow of the liquid may be the flow of a segmented sample-reagent liquid, and the other fluid which is added may be a gas.
Inventors
- 👤 Donald A. Burns
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 05:56
CPC Classifications
G; G01; G01N; G01N35/00; G01N35/08; G05; G05D; G05D7/00; G05D7/06; G05D7/0617; G05D7/0629; G05D7/0635; G05D7/0641; Y; Y10; Y10T; Y10T137/00; Y10T137/0318; Y10T137/0324; Y10T137/0329; Y10T137/2496; Y10T137/2499; Y10T137/2509
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
112 words
A method for quantitatively analyzing a constituent of a liquid sample, comprising: flowing in a first conduit portion toward a second conduit portion a stream including said sample at a constant volumetric rate; introducing at a volumetric rate continually another fluid into the stream in said first conduit portion: determining the velocity of said stream in one of said conduit portions and generating a signal in response thereto: proportionately varying said volumetric rate of said introduction of said other fluid into said first conduit portion in response to said signal to control the dwell time of said sample in said conduit portion: and analyzing said sample constituent in said second conduit portion.
Claim 2
Independent Claim
112 words
A method for quantitatively analyzing a constituent of a liquid sample, comprising: flowing in a first conduit portion toward a second conduit portion a stream including said sample at a constant volumetric rate; introducing at a volumetric rate continually another fluid into the stream in said first conduit portion: determining the velocity of said stream in one of said conduit portions and generating a signal in response thereto: proportionately varying said volumetric rate of said introduction of said other fluid into said first conduit portion in response to said signal to control the dwell time of said sample in said conduit portion: and analyzing said sample constituent in said second conduit portion.
Claim 3
Dependent Claim
57 words
A method as defined in claim 1, wherein: said flowing of said stream in said first conduit portion comprises periodically introducing into said stream a volume of a third substance, and said determination of the velocity of said stream comprises detecting said third substance at a station located at a position along the length of said conduit.
Claim 4
Dependent Claim
63 words
A method as defined in claim 1, wherein: said sample comprises an aliquot of a sample and further including flowing a second aliquot of said sample in such a stream in a third conduit portion toward a fourth conduit portion for a different analysis, and correlating the flow in said fourth conduit portion with respect to the flow in said second conduit portion.
Claim 5
Dependent Claim
23 words
A method as defined in claim 1, wherein: said introduction of said other fluid into said first conduit portion comprises flowing gas thereinto.
Claim 6
Dependent Claim
25 words
A method as defined in claim 1, wherein: said flowing of a stream in said first conduit portion comprises flowing a gas segmenting said sample.
Claim 7
Dependent Claim
80 words
A method as defined in claim 3, wherein: said correlation of said flow rate in said second and fourth conduit portions comprises introducing at a volumetric rate continually said other fluid into said third conduit portion, determining the velocity of said stream in one of said third and fourth conduit portions and generating a signal in response thereto, and proportionately varying said volumetric rate of introduction of said other fluid into said third conduit portion in response to said signal.
Claim 8
Dependent Claim
31 words
A method as defined in claim 3, wherein: said correlating of said flow rates of said streams in said second and fourth conduit portions comprises phasing the flow of said streams.
Claim 9
Dependent Claim
65 words
A method as defined in claim 1, including: flowing a stream of a series of said samples sequentially in said first conduit portion in isolated condition from one another, and varying said volumetric rate of said introduction of said other fluid into said first conduit portion in response to said signal to control the respective dwell times of said samples in said second conduit portion.
Claim 10
Dependent Claim
34 words
A method as defined in claim 8, wherein: said samples are isolated by wash solution segments intermediate said samples, and said determination of the velocity of the stream includes detecting said wash solution segments.
Claim 11
Dependent Claim
111 words
Apparatus for quantitatively analyzing a constituent of a liquid sample, comprising: means flowing in a first conduit portion toward a second conduit portion a stream including said sample at a constant volumetric rate; means introducing at a volumetric rate continually another fluid into the stream in said first conduit portion; means determining the velocity of said stream in one of said conduit portions and generating a signal in response thereto; means proportionately varying said volumetric rate of introduction of said other fluid into said first conduit portion to control the dwell time of said sample in said second conduit portion; and means analyzing said sample constituent in said second sample portion.
Claim 12
Dependent Claim
111 words
Apparatus for quantitatively analyzing a constituent of a liquid sample, comprising: means flowing in a first conduit portion toward a second conduit portion a stream including said sample at a constant volumetric rate; means introducing at a volumetric rate continually another fluid into the stream in said first conduit portion; means determining the velocity of said stream in one of said conduit portions and generating a signal in response thereto; means proportionately varying said volumetric rate of introduction of said other fluid into said first conduit portion to control the dwell time of said sample in said second conduit portion; and means analyzing said sample constituent in said second sample portion.
Claim 13
Dependent Claim
53 words
Apparatus as defined in claim 10, wherein: said means flowing a stream in said first conduit portion includes means periodically introducing into said stream a volume of a third substance, and said determination means comprises means detecting third said substance at a station located at a position along the length of said conduit.
Claim 14
Dependent Claim
68 words
Apparatus as defined in claim 10, wherein: said sample comprises an aliquot of a sample, and further including means flowing a stream including a second aliquot of said sample in a third conduit portion towards a fourth conduit portion for a different analysis in the latter, and means correlating the flow rate of said fourth conduit portion with respect to the flow rate in the second conduit portion.
Claim 15
Dependent Claim
28 words
Apparatus as defined in claim 10, wherein: said means introducing said other fluid into said first conduit portion comprises means introducing a gas into said first conduit portion.
Claim 16
Dependent Claim
89 words
Apparatus as defined in claim 12, wherein: said means correlating the flow rate in said fourth conduit portion with respect to the flow in said second conduit portion comprises means introducing said other fluid at a volumetric rate continually into said third conduit portion, means determining the velocity of said stream in one of said third and fourth conduit portions and generating a signal in response thereto, and means proportionately varying said rate of introduction of said other fluid into said third conduit portion in response to said signal.
Claim 17
Dependent Claim
32 words
Apparatus as defined in claim 12, wherein: said means correlating the flow rate in said second and fourth conduit portions comprises means phasing the flow in said second and fourth conduit portions.
Claim 18
Dependent Claim
58 words
Apparatus as defined in claim 10, wherein: said means flowing a stream in said first conduit portion flows a series of said samples in isolated condition from one another, and said means varying said rate of said introduction of said other fluid first conduit portion controls the respective dwell times of said samples in said second conduit portion.
Claim 19
Dependent Claim
42 words
Apparatus as defined in claim 16, wherein: said means introducing said samples introduces said samples isolated from each other by wash solution segments intermediate said samples, and said means determining the velocity of the stream includes means detecting said wash solution segments.
References Cited (Backward Citations)
US2780414A
Cited
US2958333A
Cited
US3435660A
Cited
US3435678A
Cited
US3435659A
Cited
US3403555A
Cited
US3600953A
Cited
US3621715A
Cited
US3739636A
Cited
US3727048A
Cited
US3760829A
Cited
US3881351A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-01-25 | 1980-07-26 | 1981-01-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-01-25 | 1984-07-26 | 1985-01-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-01-25 | 1988-07-26 | 1989-01-25 | $7700.00 | Window Closed / Lapsed |