Substituted indolinones

Claim 1

A compound of the formula ##STR73## wherein R 1 is selected from the group consisting of phenyl, naphthyl, thienyl, furyl, chlorofuryl, dichlorofuryl, pyrryl, pyridyl, coumarinyl, thiacoumarinyl, thiazolyl, isothiazolyl, imidazolyl, or phenyl or naphthyl substituted with one or more substituents selected from the group consisting of halogen, hydroxy, lower alkyl, nitro, CF 3 and lower alkoxy; R 2 is selected from the group consisting of hydrogen, lower alkyl, phenyl, naphthyl, lower alkylphenyl, or lower alkylnaphthyl; R 3 is selected from the group consisting of hydrogen, lower alkyl, trifluoromethyl, halo, lower alkoxy, nitro, cyano, amino, dilower alkylamino or ##STR74## wherein R is selected from the groups consisting of lower alkyl, lower alkenyl, phenyl, phenyl-lower alkyl, cycloalkyl, cycloalkenyl, cycloalkyl-lower alkyl, and cycloalkyl-lower alkenyl; ##STR75## represents a 5- or 6-membered ring selected from the group consisting of ##STR76## n is 1 or 2; the dotted line represents an optional bond; and pharmaceutically acceptable acid-addition salts thereof.