US4002741A
Expired / Lapsed
US
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Meglumine complex fungicidal polyene macrolide antibiotic compositions and treatment method
Assignee: Individual
•
Filing: 1975-12-04
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Granted: 1977-01-11
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Expires: 1995-12-04
Abstract
Abstract Medicated compositions which contain as active ingredients meglumine complexes of fungicidal polyene macrolide antibiotics and treatment method utilizing these compositions is described. These compounds possess fungicidal and protistocidal activity and are useful in the treatment of candidoses and aspergilloses. Additionally, meglumine complexes of amphotericin B and mycoheptine can be used for treating most systemic mycoses by way of oral and inhalation administration as well as by instillation, and for treating leishmaniasis, schistosomiasis, lambliasis and trichomoniasis.
Inventors
- 👤 Valter Osvaldovich Kulbakh
- 👤 Tatyana Mikhailovna Kokushina
- 👤 Irina Kondratievna Lagert
- 👤 Georgy Avxentievich Mikhailets
- 👤 Galina Vasilievna Kholodova
- 👤 Oleg Nikolaevich Ekzemplyarov
- 👤 Ruvim Bentsionovich Zelmanov
- 👤 Leonid Borisovich Sokolov
- 👤 Evgeny Davidovich Etingov
- 👤 Irina Mikhailovna Lushitskaya
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 17:05
CPC Classifications
C; C07; C07H; C07H17/00; C07H17/04; C07H17/08
Claims Analysis
Total Claims: 31
Claim 1
Independent Claim
36 words
A medicinal composition comprising as an active ingredient, a meglumine complex of a fungicidal polyene macrolide antibiotic of the formula: ##STR7## wherein R is the remainder of a fungicidal polyene macrolide antibiotic having no carboxyl groups.
Claim 2
Dependent Claim
36 words
A medicinal composition comprising as an active ingredient, a meglumine complex of a fungicidal polyene macrolide antibiotic of the formula: ##STR7## wherein R is the remainder of a fungicidal polyene macrolide antibiotic having no carboxyl groups.
Claim 3
Dependent Claim
26 words
A composition as claimed in claim 1, comprising as an active ingredient, a meglumine complex of amphotericin B in a dosage of 100 mg (100,000 ED).
Claim 4
Dependent Claim
25 words
A composition as claimed in claim 2, wherein the active ingredient is combined with a pharmaceutical filler in the form of a tablet or capsule.
Claim 5
Dependent Claim
19 words
A composition as claimed in claim 2, wherein the active ingredient is in the form of a sterile powder.
Claim 6
Dependent Claim
26 words
A composition as claimed in claim 1, comprising as an active ingredient, a meglumine complex of mycoheptine in a dosage of from 10 to 56 mg.
Claim 7
Dependent Claim
25 words
A composition as claimed in claim 5, wherein the active ingredient is combined with a pharmaceutical filler in the form of a table or capsule.
Claim 8
Dependent Claim
19 words
A composition as claimed in claim 5, wherein the active ingredient is in the form of a sterile powder.
Claim 9
Dependent Claim
26 words
A composition as claimed in claim 1, comprising as an active ingredient, a meglumine complex of levorine in a dosage ranging from 150,000 to 200,000 ED.
Claim 10
Dependent Claim
25 words
A composition as claimed in claim 8, wherein the active ingredient is combined with a pharmaceutical filler in the form of a tablet or capsule.
Claim 11
Dependent Claim
19 words
A composition as claimed in claim 8, wherein the active ingredient is in the form of a sterile powder.
Claim 12
Dependent Claim
23 words
A composition as claimed in claim 1, comprising as an active ingredient, a meglumine complex of nystatine in a dosage of 150,000 ED.
Claim 13
Dependent Claim
25 words
A composition as claimed in claim 11, wherein the active ingredient is combined with a pharmaceutical filler in the form of a tablet or capsule.
Claim 14
Dependent Claim
19 words
A composition as claimed in claim 11, wherein the active ingredient is in the form of a sterile powder.
Claim 15
Independent Claim
42 words
A method of treating mycoses in human beings and animals which comprises administering to said human beings and animals a meglumine complex of fungicidal polyene macrolide antibiotic of the formula: ##STR8## wherein R is the remainder of a fungicidal polyene macrolide antibiotic.
Claim 16
Independent Claim
42 words
A method of treating mycoses in human beings and animals which comprises administering to said human beings and animals a meglumine complex of fungicidal polyene macrolide antibiotic of the formula: ##STR8## wherein R is the remainder of a fungicidal polyene macrolide antibiotic.
Claim 17
Dependent Claim
32 words
A method according to claim 14 of treating systemic mycoses in human beings and animals comprising the oral administration to said human beings and animals of a meglumine complex of amphotericin B.
Claim 18
Dependent Claim
42 words
A method according to claim 14 of treating systemic mycoses in human beings and animals comprising the inhalation administration to said human beings and animals of an aqueous solution of from 2 to 10 mg/ml of a meglumine complex of amphotericin B.
Claim 19
Dependent Claim
40 words
A method according to claim 14 of treating systemic mycoses of human beings and animals comprising instillation to said human beings and animals of an aqueous solution of from 2 to 10 mg/ml of a meglumine complex of amphotericin B.
Claim 20
Independent Claim
30 words
A method of treating systemic mycoses, candidoses and aspergilloses in human beings and animals comprising the oral administration to said human beings and animals of a meglumine complex of mycoheptine.
Claim 21
Independent Claim
30 words
A method of treating systemic mycoses, candidoses and aspergilloses in human beings and animals comprising the oral administration to said human beings and animals of a meglumine complex of mycoheptine.
Claim 22
Dependent Claim
44 words
A method according to claim 18 of treating systemic mycoses, candidoses and aspergilloses in human beings and animals comprising the inhalation administration to said human beings and animals of an aqueous solution of from 2 to 10 mg/ml of a meglumine complex of mycoheptine.
Claim 23
Dependent Claim
31 words
A method according to claim 18 of treating systemic mycoses, candidoses and aspergilloses in human beings and animals comprising instillation to said human beings and animals of meglumine complex of mycoheptine.
Claim 24
Independent Claim
28 words
A method of treating candidoses and aspergilloses in human beings and animals comprising the oral administration to said human beings and animals of a meglumine complex of levorine.
Claim 25
Independent Claim
28 words
A method of treating candidoses and aspergilloses in human beings and animals comprising the oral administration to said human beings and animals of a meglumine complex of levorine.
Claim 26
Dependent Claim
42 words
A method according to claim 21 of treating candidoses and aspergilloses in human beings and animals comprising the inhalation administration to said human beings and animals of an aqueous solution of from 10,000 to 40,000 ED/ml of a meglumine complex of levorine.
Claim 27
Dependent Claim
40 words
A method according to claim 21 of treating candidoses and aspergilloses in human beings and animals comprising instillation to said human beings and animals of an aqueous solution of from 10,000 to 40,000 ED/ml of a meglumine complex of levorine.
Claim 28
Independent Claim
28 words
A method of treating candidoses and aspergilloses in human beings and animals comprising the oral administration to said human beings and animals of a meglumine complex of nystatine.
Claim 29
Independent Claim
28 words
A method of treating candidoses and aspergilloses in human beings and animals comprising the oral administration to said human beings and animals of a meglumine complex of nystatine.
Claim 30
Dependent Claim
42 words
A method according to claim 24 of treating candidoses and aspergilloses in human beings and animals comprising the inhalation administration to said human beings and animals of an aqueous solution of from 10,000 to 40,000 ED/ml of a meglumine complex of nystatine.
Claim 31
Dependent Claim
40 words
A method according to claim 24 of treating candidoses and aspergilloses in human beings and animals comprising instillation to said human beings and animals of an aqueous solution of from 10,000 to 40,000 ED/ml of a meglumine complex of nystatine.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-01-11 | 1980-07-12 | 1981-01-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-01-11 | 1984-07-12 | 1985-01-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-01-11 | 1988-07-12 | 1989-01-11 | $7700.00 | Window Closed / Lapsed |