US4001209A
Expired / Lapsed
US
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Antibiotic g-52 and method for the production thereof
Assignee: Merck Sharp & Dohme LLC
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Filing: 1975-02-28
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Granted: 1977-01-04
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Expires: 1995-02-28
Abstract
Abstract A novel actinomycete herein designated Micromonospora zionensis elaborates a product having substantial antibacterial activity, said activity being due to sisomicin and the novel antibiotic substance coproduced therewith. The disclosure sets forth methods for producing, isolating and using the antibiotics.
Inventors
- 👤 Marvin J. Weinstein
- 👤 Gerald H. Wagman
- 👤 Joseph A. Marquez
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 00:21
CPC Classifications
C; C07; C07H; C07H15/00; C07H15/20; C07H15/22; C07H15/222; C07H15/226; C07H15/234; C07H15/236; A; A61; A61P; A61P31/00; A61P31/04; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/863
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
21 words
A composition of matter selected from the group consisting of Antibiotic G-52, non-toxic acid addition salts and Schiff base-oxazolidine derivatives thereof.
Claim 2
Dependent Claim
21 words
A composition of matter selected from the group consisting of Antibiotic G-52, non-toxic acid addition salts and Schiff base-oxazolidine derivatives thereof.
Claim 3
Dependent Claim
103 words
A composition of matter defined in claim 1, said composition of matter being Antibiotic G-52 having: a. a molecular weight of 461 as determined by mass spectometry; b. a pKa of 8.2; c. the empirical formula C 20 H 39 N 5 O 7 ; d. a specific optical rotation as measured by D line of sodium of 156.4° in water at 0.3% concentration; e. a nuclear magnetic resonance spectrum in deuterium oxide substantially as shown in FIG. 1; f. an infrared absorption spectrum in mineral oil substantially as shown in FIG. 2; and said Antibiotic G-52 having the following structural formula: ##SPC3##
Claim 4
Dependent Claim
19 words
A composition of matter defined in claim 1, said composition being a non-toxic acid addition salt of Antibiotic G-52.
Claim 5
Dependent Claim
14 words
A composition of matter defined in claim 3, said compound being Antibiotic G-52 sulfate.
Claim 6
Dependent Claim
7 words
A Schiff base-oxazolidine derivative of Antibiotic G-52.
Claim 7
Dependent Claim
7 words
A Schiff base-oxazolidine derivative of Antibiotic G-52.
References Cited (Backward Citations)
US3651042A
Cited
US3832286A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-01-04 | 1980-07-05 | 1981-01-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-01-04 | 1984-07-05 | 1985-01-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-01-04 | 1988-07-05 | 1989-01-04 | $7700.00 | Window Closed / Lapsed |