US4000288A
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US
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6,11-dihydrodibenzo-thiepin-11-ones, compositions and uses thereof
Assignee: Syntex USA LLC
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Filing: 1975-11-21
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Granted: 1976-12-28
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Expires: 1995-11-21
Abstract
Abstract This invention relates to novel 6,11-dihydrodibenzo-[b.e.]-thiepin-11-ones, methods of preparation, compositions and uses thereof.
Inventors
- 👤 Jack Ackrell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 18:16
CPC Classifications
C; C07; C07C; C07C323/00; C07C205/00; C07C205/49; C07C205/57; C07D; C07D337/00; C07D337/02; C07D337/06; C07D337/10; C07D337/12
Claims Analysis
Total Claims: 35
Claim 1
Independent Claim
56 words
A compound of the formula: ##STR20## or the individual (d)-acid isomer, or (1)-acid isomer of Formula (B), wherein R is hydrogen, an alkyl group containing from one to twelve carbon atoms, or a pharmaceutically acceptable salt thereof when R is hydrogen, or the said esters and pharmaceutically acceptable salts of the individual isomers of Formula (B).
Claim 2
Dependent Claim
56 words
A compound of the formula: ##STR20## or the individual (d)-acid isomer, or (1)-acid isomer of Formula (B), wherein R is hydrogen, an alkyl group containing from one to twelve carbon atoms, or a pharmaceutically acceptable salt thereof when R is hydrogen, or the said esters and pharmaceutically acceptable salts of the individual isomers of Formula (B).
Claim 3
Dependent Claim
47 words
A compound of the formula: ##STR21## or the (d)-acid isomer thereof, wherein R is hydrogen, an alkyl group containing from one to twelve carbon atoms, or a pharmaceutically acceptable salt thereof when R is hydrogen, or the said esters and pharmaceutically acceptable salts of the (d)-acid isomer.
Claim 4
Dependent Claim
47 words
A compound of the formula: ##STR21## or the (d)-acid isomer thereof, wherein R is hydrogen, an alkyl group containing from one to twelve carbon atoms, or a pharmaceutically acceptable salt thereof when R is hydrogen, or the said esters and pharmaceutically acceptable salts of the (d)-acid isomer.
Claim 5
Dependent Claim
30 words
A compound of the formula: ##STR22## wherein R is hydrogen, an alkyl group containing from one to twelve carbon atoms, or a pharmaceutically acceptable salt thereof when R is hydrogen.
Claim 6
Dependent Claim
30 words
A compound of the formula: ##STR22## wherein R is hydrogen, an alkyl group containing from one to twelve carbon atoms, or a pharmaceutically acceptable salt thereof when R is hydrogen.
Claim 7
Dependent Claim
30 words
A compound of the formula: ##STR23## wherein R is hydrogen, an alkyl group containing from one to twelve carbon atoms, or a pharmaceutically acceptable salt thereof when R is hydrogen.
Claim 8
Dependent Claim
30 words
A compound of the formula: ##STR23## wherein R is hydrogen, an alkyl group containing from one to twelve carbon atoms, or a pharmaceutically acceptable salt thereof when R is hydrogen.
Claim 9
Dependent Claim
30 words
A compound of the formula: ##STR24## wherein R is hydrogen, an alkyl group containing from one to twelve carbon atoms, or a pharmaceutically acceptable salt thereof when R is hydrogen.
Claim 10
Dependent Claim
30 words
A compound of the formula: ##STR24## wherein R is hydrogen, an alkyl group containing from one to twelve carbon atoms, or a pharmaceutically acceptable salt thereof when R is hydrogen.
Claim 11
Dependent Claim
13 words
The (dl) compound of claim 1 wherein R is hydrogen, (dl)-2-(6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3yl) propionic acid.
Claim 12
Dependent Claim
13 words
The (dl) compound of claim 1 wherein R is methyl, methyl (dl)-2-(6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-yl) propionate.
Claim 13
Dependent Claim
13 words
The (dl) compound of claim 1 wherein R is isoamyl, isoamyl (dl)-2-(6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-yl) propionate.
Claim 14
Dependent Claim
13 words
The sodium salt of the (dl) compound of claim 1, sodium (dl)-2-(6,11-dihydrodibenzo-[b.e.]-thiepin-11one-3-yl) propionate.
Claim 15
Dependent Claim
13 words
The potassium salt of the (dl) compound of claim 1, potassium (dl)-2-(6,11-dihydrodibenzo-b.e.]-thiepin-11one-3-yl) propionate.
Claim 16
Dependent Claim
13 words
The calcium salt of the (dl) compound of claim 1, calcium (dl)-2-(6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-yl) propionate.
Claim 17
Dependent Claim
13 words
The copper salt of the (dl) compound of claim 1, copper (dl)-2-(6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-yl) propionate.
Claim 18
Dependent Claim
13 words
The piperidinium salt of the (dl) compound of claim 1, piperidinium (dl)-2-(6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-yl) propionate.
Claim 19
Dependent Claim
13 words
The (d)-isomer compound of claim 1 wherein R is hydrogen, (d)-2-(6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-yl) propionic acid.
Claim 20
Dependent Claim
18 words
The (d)-acid isomer compound of claim 1 wherein R is methyl, the methyl ester of (d)-2-(6,11-dihydrodibenzo-[b.e.]-thiepin-11one-3-yl) propionic acid.
Claim 21
Dependent Claim
18 words
The (d)-acid isomer compound of claim 1 wherein R is isoamyl, the isoamyl ester of (d)-2-(6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-yl) propionic acid.
Claim 22
Dependent Claim
18 words
The sodium salt of the (d)-acid isomer compound of claim 1, the sodium salt of (d)-2-(6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-yl) propionic acid.
Claim 23
Dependent Claim
18 words
The potassium salt of the (d)-acid isomer compound of claim 1, the potassium salt of (d)-2-(6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-yl) propionic acid.
Claim 24
Dependent Claim
18 words
The calcium salt of the (d)-acid isomer compound of claim 1, the calcium salt of (d)-2-(6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-yl) propionic acid.
Claim 25
Dependent Claim
18 words
The copper salt of the (d)-acid isomer compound of claim 1, the copper salt of (d)-2-(6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-yl) propionic acid.
Claim 26
Dependent Claim
18 words
The piperidinium salt of the (d)-acid isomer compound of claim 1, the piperidinium salt of (d)-2-(6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-yl) propionic acid.
Claim 27
Dependent Claim
13 words
The (1)-isomer compound of claim 1 wherein R is hydrogen, (1)-2-(6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-yl) propionic acid.
Claim 28
Dependent Claim
3 words
Dicyclohexylammonium (dl)-2-(6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-yl) propionate.
Claim 29
Dependent Claim
3 words
Dicyclohexylammonium (dl)-2-(6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-yl) propionate.
Claim 30
Dependent Claim
74 words
A composition for treating inflammation, pain or pyrexia in mammals consisting essentially of a pharmaceutically acceptable non-toxic excipient and a therapeutically effective amount of a compound represented by the formula: ##STR25## or the (d)-acid isomer of Formula (B), wherein R is hydrogen, an alkyl group containing from one to twelve carbon atoms, or a pharmaceutically acceptable salt thereof when R is hydrogen, or the said esters and pharmaceutically acceptable salts of the (d)-acid isomer.
Claim 31
Dependent Claim
74 words
A composition for treating inflammation, pain or pyrexia in mammals consisting essentially of a pharmaceutically acceptable non-toxic excipient and a therapeutically effective amount of a compound represented by the formula: ##STR25## or the (d)-acid isomer of Formula (B), wherein R is hydrogen, an alkyl group containing from one to twelve carbon atoms, or a pharmaceutically acceptable salt thereof when R is hydrogen, or the said esters and pharmaceutically acceptable salts of the (d)-acid isomer.
Claim 32
Independent Claim
73 words
A method of treating inflammation, pain or pyrexia in mammals which comprises administering to a mammal suffering therefrom a therapeutically effective amount of a compound represented by the formula: ##STR26## or the (d)-acid isomer of Formula (B), wherein R is hydrogen, an alkyl group containing from one to twelve carbon atoms, or a pharmaceutically acceptable salt thereof when R is hydrogen, or the said esters and pharmaceutically acceptable salts of the (d)-acid isomer.
Claim 33
Independent Claim
73 words
A method of treating inflammation, pain or pyrexia in mammals which comprises administering to a mammal suffering therefrom a therapeutically effective amount of a compound represented by the formula: ##STR26## or the (d)-acid isomer of Formula (B), wherein R is hydrogen, an alkyl group containing from one to twelve carbon atoms, or a pharmaceutically acceptable salt thereof when R is hydrogen, or the said esters and pharmaceutically acceptable salts of the (d)-acid isomer.
Claim 34
Dependent Claim
78 words
A composition for administration to a pregnant mammal to delay the onset of parturition consisting essentially of a pharmaceutically acceptable non-toxic excipient and a therapeutically effective amount of a compound represented by the formula: ##STR27## or the (d)-acid isomer of Formula (B), wherein R is hydrogen, an alkyl group containing from one to twelve carbon atoms, or a pharmaceutically acceptable salt thereof when R is hydrogen, or the said esters and pharmaceutically acceptable salts of the (d)-acid isomer.
Claim 35
Dependent Claim
78 words
A composition for administration to a pregnant mammal to delay the onset of parturition consisting essentially of a pharmaceutically acceptable non-toxic excipient and a therapeutically effective amount of a compound represented by the formula: ##STR27## or the (d)-acid isomer of Formula (B), wherein R is hydrogen, an alkyl group containing from one to twelve carbon atoms, or a pharmaceutically acceptable salt thereof when R is hydrogen, or the said esters and pharmaceutically acceptable salts of the (d)-acid isomer.
References Cited (Backward Citations)
US3946036A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-12-28 | 1980-06-28 | 1980-12-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-12-28 | 1984-06-28 | 1984-12-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-12-28 | 1988-06-28 | 1988-12-28 | $7700.00 | Window Closed / Lapsed |