US4000193A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pharmacologically active compounds
Assignee: Allen and Hanburys Ltd
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Filing: 1974-05-06
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Granted: 1976-12-28
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Expires: 1994-05-06
Abstract
Abstract Compounds of the formula: ##STR1## in which: R 4 and R 5 independently represent hydrogen or lowr alkyl; R 6 represents a straight or branched alkyl or alkenyl group containing from 4 to 6 carbon atoms, inclusive, or R 6 represents a straight or branched alkyl group containing from 2 to 6 carbon atoms, inclusive, which alkyl group is substituted by one or more hydroxy, alkoxy or acyloxy groups; or by an aryl group which may be substituted by one or more hydroxy, alkoxy or acyloxy groups as before; and R 7 represents a straight or branched alkyl group containing from 3 to 6 carbon atoms, inclusive, optionally substituted by an alkoxy group or by an aryl or aryloxy group which, alkoxy, aryl or aryloxy group may, in turn be substituted by hydroxy, alkoxy, acetamido or methanesulphonamido groups, And pharmaceutically acceptable salts thereof. These compounds have utility in the treatment of cardiovascular diseases.
Inventors
- 👤 Lawrence Henry Charles Lunts
- 👤 David Trevor Collin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 08:35
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/16
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
153 words
A compound of the formula ##STR18## in which R 4 and R 5 independently represent hydrogen or lower alkyl; R 6 represents a straight or branched alkyl or alkenyl group containing from 4 to 6 carbon atoms, inclusive, or R 6 represents a straight or branched alkyl group containing from 2 to 6 carbon atoms, inclusive, which alkyl group is substituted by one or more hydroxy, alkoxy or acyloxy groups; or by an aryl group which may be substituted by one or more hydroxy, alkoxy or acyloxy groups as before; and R 7 represents a straight or branched alkyl group containing from 3 to 6 carbon atoms, inclusive, optionally substituted by an aryl substituted with hydroxy, alkoxy, acetamido or methanesulphonamido groups; or optionally substituted by an alkoxy group or aryloxy group which, alkoxy or aryloxy group may, in turn, be substituted by hydroxy, alkoxy, acetamido or methanesulphonamido groups, and pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
153 words
A compound of the formula ##STR18## in which R 4 and R 5 independently represent hydrogen or lower alkyl; R 6 represents a straight or branched alkyl or alkenyl group containing from 4 to 6 carbon atoms, inclusive, or R 6 represents a straight or branched alkyl group containing from 2 to 6 carbon atoms, inclusive, which alkyl group is substituted by one or more hydroxy, alkoxy or acyloxy groups; or by an aryl group which may be substituted by one or more hydroxy, alkoxy or acyloxy groups as before; and R 7 represents a straight or branched alkyl group containing from 3 to 6 carbon atoms, inclusive, optionally substituted by an aryl substituted with hydroxy, alkoxy, acetamido or methanesulphonamido groups; or optionally substituted by an alkoxy group or aryloxy group which, alkoxy or aryloxy group may, in turn, be substituted by hydroxy, alkoxy, acetamido or methanesulphonamido groups, and pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
16 words
A compound as claimed in claim 1 in which R 4 and R 5 are hydrogen.
Claim 4
Dependent Claim
30 words
A compound as claimed in claim 1 in which R 6 represents one of the following groups: C 4-6 alkyl, dihydroxyalkyl, hydroxyalkyl, alkoxyalkyl, acyloxyalkyl, aralkyl, hydroxyaralkyl, alkoxyaralkyl, acyloxyaralkyl, or alkenyl.
Claim 5
Dependent Claim
22 words
A compound as claimed in claim 1 in which R 7 represents alkyl, alkoxyalkyl, hydroxyaralkyl, mono and dialkoxyaralkyl, alkoxyhydroxyaralkyl acetamidoaralkyl, sulphonamidoaralkyl, aryloxyalkyl.
Claim 6
Dependent Claim
13 words
The compound of claim 1 which is 2-(2-ethoxyethoxy)-5-[1-hydroxy -2-[[3-(4-hydroxyphenyl)-1-methylpropyl] amino] ethyl] benzamide, hydrochloride.
Claim 7
Dependent Claim
9 words
The compound of claim 1 which is 2-(2-ethoxyethoxy)-5-[1-hydroxy-2[(3-methoxy-1-methylpropyl)amino]ethyl]benzamide, hydrochloride.
Claim 8
Dependent Claim
9 words
The compound of claim 1 which is 5-[2-[3-(4-acetamidophenyl)-1-methylpropyl]amino-1-hydroxyethyl]-2-(2-ethoxyethoxy)benzamide, hydrochloride.
Claim 9
Dependent Claim
9 words
The compound of claim 1 which is 2-(ethoxyethoxy)-5-[1-hydroxy-2[[3-(4-hydroxy-3-methoxyphenyl)-1-methylpropyl]-amino]ethyl]benzamide, hydrochloride.
Claim 10
Dependent Claim
12 words
The compound of claim 1 which is 2-(2-hydroxyethoxy)-5-(1-hydroxy-2[(3-[4-hydroxyphenyl] -1-methylpropyl)amino] ethyl)benzamide, hydrochloride, sesquihydrate.
References Cited (Backward Citations)
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GB1260521A
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-12-28 | 1980-06-28 | 1980-12-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-12-28 | 1984-06-28 | 1984-12-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-12-28 | 1988-06-28 | 1988-12-28 | $7700.00 | Window Closed / Lapsed |