US3994901A
Expired / Lapsed
US
⏱️ 0.0 years remaining
5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-hydroxy-3,4-dihydrocarbostyril derivatives
Assignee: Otsuka Pharmaceutical Co Ltd
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Filing: 1974-12-26
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Granted: 1976-11-30
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Expires: 1994-12-26
Abstract
Abstract 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-hydroxy-3,4-dihydrocarbostyril derivatives having the formula (I) +Q,10 wherein R1 represents an alkyl group having 1 to 4 carbon atoms, and R2 and R3, which may be the same or different, each represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an aralkyl group containing a straight or branched chain alkyl moiety having 1 to 4 carbon atoms or a cycloalkyl group having 4 to 6 carbon atoms, or R2 and R3 may, when taken together with the nitrogen atom to which they are attached, form a 5- or 6-membered substituted or unsubstituted heterocyclic ring containing 1 or 2 nitrogen, oxygen or sulfur atoms as hetero atoms, the pharmaceutically acceptable acid addition salts thereof, and a process for preparing the same. These compounds posess a beta -adreno-receptor stimulating activity.
Inventors
- 👤 Kazuyuki Nakagawa
- 👤 Shiro Yoshizaki
- 👤 Kaoru Tanimura
- 👤 Shigeharu Tamada
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 11:42
CPC Classifications
C; C07; C07D; C07D215/00; C07D215/02; C07D215/16; C07D215/20; C07D215/24; C07D215/26
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
131 words
A 5-[1-hydroxy-2-(substituted-amino)]alkyl-8-hydroxy-3,4-dihydrocarbostyril compound having the formula ##SPC15## wherein R 1 represents an alkyl group having 1 to 4 carbon atoms, and R 2 and R 3 , which may be the same or different, each represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, a phenylalkyl group wherein the alkyl moiety is straight or branched chain alkyl having 1 to 4 carbon atoms or cycloalkyl having 4 to 6 carbon atoms, or R 2 and R 3 may, when taken together with the nitrogen atom to which they are attached, form a 5- or 6-membered substituted, by an alkyl group having 1 to 4 carbon atoms, or unsubstituted heterocyclic ring selected from the group consisting of pyrrolidino and piperidino, and the pharmaceutically acceptable acid addition salts thereof.
Claim 2
Dependent Claim
131 words
A 5-[1-hydroxy-2-(substituted-amino)]alkyl-8-hydroxy-3,4-dihydrocarbostyril compound having the formula ##SPC15## wherein R 1 represents an alkyl group having 1 to 4 carbon atoms, and R 2 and R 3 , which may be the same or different, each represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, a phenylalkyl group wherein the alkyl moiety is straight or branched chain alkyl having 1 to 4 carbon atoms or cycloalkyl having 4 to 6 carbon atoms, or R 2 and R 3 may, when taken together with the nitrogen atom to which they are attached, form a 5- or 6-membered substituted, by an alkyl group having 1 to 4 carbon atoms, or unsubstituted heterocyclic ring selected from the group consisting of pyrrolidino and piperidino, and the pharmaceutically acceptable acid addition salts thereof.
Claim 3
Dependent Claim
6 words
5-(1-Hydroxy-2-isopropylamino)propyl -8-hydroxy-3,4-dihydrocarbostyril according to claim 1.
Claim 4
Dependent Claim
5 words
5-(1-Hydroxy-2-isopropylamino)butyl-8-hydroxy-3,4-dihydrocarbostyril according to claim 1.
Claim 5
Dependent Claim
5 words
5-(1-Hydroxy-2-tert-butylamino)butyl-8-hydroxy-3,4-dihydrocarbostyril according to claim 1.
Claim 6
Dependent Claim
5 words
5-(1-Hydroxy-2-sec-butylamino)butyl-8-hydroxy-3,4-dihydrocarbostyril according to claim 1.
Claim 7
Dependent Claim
5 words
5-(1-Hydroxy-2-tert-butylamino)propyl-8-hydroxy-3,4-dihydrocarbostyril according to claim 1.
Claim 8
Dependent Claim
5 words
5-(1-Hydroxy-2-isopropylamino)ethyl-8-hydroxy-3,4-dihydrocarbostyril according to claim 1.
Claim 9
Dependent Claim
5 words
5-(1-Hydroxy-2-amino)ethyl-8-hydroxy-3,4-dihydrocarbostyril according to claim 1.
Claim 10
Dependent Claim
5 words
5-(1-Hydroxy-2-ethylamino)butyl-8-hydroxy-3,4-dihydrocarbostyril according to claim 1.
Claim 11
Dependent Claim
5 words
5-[1-Hydroxy-2-(2-phenethylamino)butyl]-8-hydroxy-3,4-dihydrocarbostyril according to claim 1.
Claim 12
Dependent Claim
5 words
5-(1-Hydroxy-2-tert-butylamino)propyl-8-hydroxy-3,4-dihydrocarbostyril according to claim 1.
References Cited (Backward Citations)
US3444173A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-11-30 | 1980-05-31 | 1980-11-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-11-30 | 1984-05-31 | 1984-11-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-11-30 | 1988-05-31 | 1988-11-30 | $7700.00 | Window Closed / Lapsed |