US3994828A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Nonabsorbable antioxidant
Assignee: ATK Launch Systems LLC
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Filing: 1973-06-07
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Granted: 1976-11-30
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Expires: 1993-06-07
Abstract
Abstract Novel, nonabsorbable antioxidants of the general formula (An) n R wherein An is a means for preventing oxidation of an oxidizable material, R is a means for essentially restricting the absorption of An in a biological environment, ˜ is a means for covalently bonding An to R for a prolonged time, and n is at least one. The nonabsorbable antioxidants are useful as stabilizers in oxidizable materials without any substantial absorption of the antioxidant in the biological environment.
Inventors
- 👤 Alejandro Zaffaroni
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 05:35
CPC Classifications
A; A23; A23B; A23B2/00; A23B2/70; A23B2/725; A23B2/729; C; C08; C08K; C08K9/00
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
130 words
A nonabsorbable nonnutritive antioxidant consisting essentially of compounds having a molecular weight in excess of 1000 and having the formula (An) n R wherein An is an antioxidant capable of substantially retarding the rate of oxidation of an oxidizable material, n is a number having a value of at least 1, R is a polymeric restricting means which is essentially nonmetabolizable and nonbiodegradable under the conditions of passage through the gastrointestinal tract, and ˜ is a covalent bond that substantially maintains its physical and chemical integrity under the conditions of passage through the gstrointestinal tract and wherein during passage of (An) n R through the gastrointestinal tract, the restricing means, R, substantially prevents passage of (An) n R from the gastrointestinal lumen through the gastrointestinal mucosa into the systemic circulation.
Claim 2
Dependent Claim
130 words
A nonabsorbable nonnutritive antioxidant consisting essentially of compounds having a molecular weight in excess of 1000 and having the formula (An) n R wherein An is an antioxidant capable of substantially retarding the rate of oxidation of an oxidizable material, n is a number having a value of at least 1, R is a polymeric restricting means which is essentially nonmetabolizable and nonbiodegradable under the conditions of passage through the gastrointestinal tract, and ˜ is a covalent bond that substantially maintains its physical and chemical integrity under the conditions of passage through the gstrointestinal tract and wherein during passage of (An) n R through the gastrointestinal tract, the restricing means, R, substantially prevents passage of (An) n R from the gastrointestinal lumen through the gastrointestinal mucosa into the systemic circulation.
Claim 3
Dependent Claim
14 words
A nonabsorbable, nonnutritive antioxidant according to claim 1 wherein An is a phenolic moiety.
Claim 4
Dependent Claim
17 words
A nonabsorbable, nonnutritive antioxidant according to claim 2 wherein ˜is a carbon to carbon single covalent bond.
Claim 5
Dependent Claim
23 words
A nonabsorbable, nonnutritive antioxidant according to claim 3 wherein R is a synthetic organic polymer having a molecular weight in excess of 400.
Claim 6
Dependent Claim
23 words
A nonabsorbable, nonnutritive antioxidant according to claim 1 wherein R is a biologically acceptable polymer having a molecular weight in excess of 500.
Claim 7
Dependent Claim
25 words
A nonabsorbable, nonnutritive antioxidant according to claim 1 wherein the means for restricting passage of the antioxidant through the wall is a biologically acceptable oligomer.
Claim 8
Dependent Claim
115 words
A nonabsorbable antioxidant compound consisting essentially of p + 2 units of an antioxidant agent which agent is useful for stabilizing an oxidizable material, the agent covalently bonded through a position on the agent that is nonessential for its activity with a covalent bond that substantially maintains its physical and chemical integrity in a biological environment into an oligomer that is substantially nonmetabolizable in the environment, said oligomer containing p + 2 units of agent, wherein p is selected in the range of from 0 to 15,000 such that the oligomer's molecular dimensions restrict the movement of the agent in the environment by substantially preventing passage of the compound through the wall of the environment.
Claim 9
Dependent Claim
115 words
A nonabsorbable antioxidant compound consisting essentially of p + 2 units of an antioxidant agent which agent is useful for stabilizing an oxidizable material, the agent covalently bonded through a position on the agent that is nonessential for its activity with a covalent bond that substantially maintains its physical and chemical integrity in a biological environment into an oligomer that is substantially nonmetabolizable in the environment, said oligomer containing p + 2 units of agent, wherein p is selected in the range of from 0 to 15,000 such that the oligomer's molecular dimensions restrict the movement of the agent in the environment by substantially preventing passage of the compound through the wall of the environment.
References Cited (Backward Citations)
US3792177A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-11-30 | 1980-05-31 | 1980-11-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-11-30 | 1984-05-31 | 1984-11-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-11-30 | 1988-05-31 | 1988-11-30 | $7700.00 | Window Closed / Lapsed |