US3993753A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Anhydrous ampicillin stabilization and resultant compositions
Assignee: Wyeth LLC
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Filing: 1975-08-21
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Granted: 1976-11-23
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Expires: 1995-08-21
Abstract
Abstract The formation of hydrates of anhydrous ampicillin in aqueous suspension may be retarded or entirely prevented for extended periods by (1) the addition of about 70 to 86% w/v of sucrose and (2) adjustment of the product pH to about 5.0 to 6.5. The invention is useful in extending the shelf life of aqueous dosage forms of anhydrous ampicillin.
Inventors
- 👤 Surendra M. Bahal
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 14:15
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/06; A61K47/26; A61K31/00; A61K31/33; A61K31/395; A61K31/41; A61K31/425; A61K31/429; A61K31/43
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
110 words
A stabilized aqueous pharmaceutical suspension comprising: A. 1.25 to 10 percent by weight per volume of anhydrous ampicillin; B. a member selected from the class consisting of a minimum range of 10-50% w/v dextrose, a minimum range of 10-35% w/v galactose, and a minimum range of 5-25% w/v sodium chloride; and C. a buffer adjusting the pH to a range between about 5 to 6.5, wherein said lowest minimum range of solutes is used at pH 6.5 at 25° C and said highest minimum range of solute is used at pH 5 at about 5° C with the proviso that galactose is not effective below pH 6.0 at 5° C.
Claim 2
Dependent Claim
110 words
A stabilized aqueous pharmaceutical suspension comprising: A. 1.25 to 10 percent by weight per volume of anhydrous ampicillin; B. a member selected from the class consisting of a minimum range of 10-50% w/v dextrose, a minimum range of 10-35% w/v galactose, and a minimum range of 5-25% w/v sodium chloride; and C. a buffer adjusting the pH to a range between about 5 to 6.5, wherein said lowest minimum range of solutes is used at pH 6.5 at 25° C and said highest minimum range of solute is used at pH 5 at about 5° C with the proviso that galactose is not effective below pH 6.0 at 5° C.
Claim 3
Dependent Claim
42 words
A stabilized aqueous pharmaceutical suspension as defined in claim 1 comprising: A. 2.5 to 10% w/v of anyhydrous ampicillin; B. a minimum range of 10-50% w/v dextrose and C. a buffer adjusting the pH to a range between about 5.0 to 6.5.
Claim 4
Dependent Claim
32 words
A stabilized aqueous pharmaceutical composition as defined in claim 1 comprising: A. 2.5 to 10% w/v of anhydrous ampicillin; and B. a minimum range of 5 to 25% w/v of sodium chloride
Claim 5
Dependent Claim
47 words
A stabilized aqueous pharmaceutical composition for storage at 5°-25° C. as defined in claim 1 comprising: A. 2.5 to 10% w/v of anhydrous ampicillin; B. a minimum range of 10-35% w/v galactose; and C. a buffer adjusting the pH to a range between about 5.0 to 6.5.
References Cited (Backward Citations)
US3351527A
Cited
US3317389A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-11-23 | 1980-05-24 | 1980-11-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-11-23 | 1984-05-24 | 1984-11-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-11-23 | 1988-05-24 | 1988-11-23 | $7700.00 | Window Closed / Lapsed |