US3987192A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Compositions and process of treatment
Assignee: Pharmacia and Upjohn Co
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Filing: 1974-07-18
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Granted: 1976-10-19
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Expires: 1994-07-18
Abstract
Abstract This invention relates to pharmaceutical compositions containing known compounds of the formula ##SPC1## Wherein M is selected from the group consisting of hydrogen, aluminum, ammonium, sodium, potassium, calcium, tris(hydroxymethyl)methylammonium and lower alkyl of 1 through 4 carbon atoms, R is selected from the group consisting of hydrogen and lower alkyl of 1 through 4 carbon atoms, and R 1 and R 2 are selected from the group consisting of hydrogen, fluorine, chlorine, bromine, trifluoromethyl, lower alkoxy of 1 through 4 carbon atoms and lower alkyl of 1 through 4 carbon atoms. The compounds (1) above are formulated with pharmaceutical carriers for inhalation or for oral, parenteral or rectal administration, with insufflation being the preferred method. The compositions are useful in the prophylactic treatment of sensitized humans and mammals for allergic and all anaphylactic reactions of a reaginmediated and non-reagin-mediated nature.
Inventors
- 👤 John B. Wright
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 08:37
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/275
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
166 words
A pharmaceutical composition useful for the prophylaxis of asthma, rhinitis, food allergy and uticaria symptoms which comprises as the sole active agent an anti-asthma, rhinitis, food allergy or uticaria effective amount of a compound of the formula ##SPC3## wherein M is selected from the group consisting of hydrogen, aluminum, ammonium, sodium, potassium, calcium, tris(hydroxymethyl)methyl ammonium and lower alkyl of 1 through 4 carbon atoms, R is selected from the group consisting of hydrogen and lower alkyl of 1 through 4 carbon atoms, and R 1 and R 2 are selected from the group consisting of hydrogen, fluorine, chlorine, bromine, trifluoromethyl, lower alkoxy of 1 through 4 carbon atoms and lower alkyl of 1 through 4 carbon atoms, in association with a pharmaceutical carrier for oral, parenteral, inhalation or rectal route of administration and in a dosage form selected from the group consisting of tablet, capsule, pill, powder for insufflation, aerosol solution for insufflation, aqueous solution, syrup, elixir, aqueous suspension, sterile aqueous solution and suspension, and suppository.
Claim 2
Dependent Claim
166 words
A pharmaceutical composition useful for the prophylaxis of asthma, rhinitis, food allergy and uticaria symptoms which comprises as the sole active agent an anti-asthma, rhinitis, food allergy or uticaria effective amount of a compound of the formula ##SPC3## wherein M is selected from the group consisting of hydrogen, aluminum, ammonium, sodium, potassium, calcium, tris(hydroxymethyl)methyl ammonium and lower alkyl of 1 through 4 carbon atoms, R is selected from the group consisting of hydrogen and lower alkyl of 1 through 4 carbon atoms, and R 1 and R 2 are selected from the group consisting of hydrogen, fluorine, chlorine, bromine, trifluoromethyl, lower alkoxy of 1 through 4 carbon atoms and lower alkyl of 1 through 4 carbon atoms, in association with a pharmaceutical carrier for oral, parenteral, inhalation or rectal route of administration and in a dosage form selected from the group consisting of tablet, capsule, pill, powder for insufflation, aerosol solution for insufflation, aqueous solution, syrup, elixir, aqueous suspension, sterile aqueous solution and suspension, and suppository.
Claim 3
Dependent Claim
12 words
A pharmaceutical composition in accordance with claim 1 wherein R is hydrogen.
Claim 4
Dependent Claim
15 words
A pharmaceutical composition in accordance with claim 2 wherein said carrier is suitable for inhalation.
Claim 5
Dependent Claim
17 words
A pharmaceutical composition in accordance with claim 3 wherein said carrier is suitable for insufflation or aerosolization.
Claim 6
Independent Claim
125 words
A method for prophylactically treating asthma, rhinitis, food allergy or uticaria in mammals which comprises administering to a mammal in need of such treatment an anti-asthma, rhinitis, food allergy or uticaria effective amount of a compound of the formula ##SPC4## wherein M is selected from the group consisting of hydrogen, aluminum, ammonium, sodium, potassium, calcium, tris(hydroxymethyl)methyl ammonium and lower alkyl of 1 through 4 carbon atoms, R is selected from the group consisting of hydrogen and lower alkyl of 1 through 4 carbon atoms, and R 1 and R 2 are selected from the group consisting of hydrogen, fluorine, chlorine, bromine, trifluoromethyl, lower alkoxy of 1 through 4 carbon atoms and lower alkyl of 1 through 4 carbon atoms, in association with a pharmaceutical carrier.
Claim 7
Independent Claim
125 words
A method for prophylactically treating asthma, rhinitis, food allergy or uticaria in mammals which comprises administering to a mammal in need of such treatment an anti-asthma, rhinitis, food allergy or uticaria effective amount of a compound of the formula ##SPC4## wherein M is selected from the group consisting of hydrogen, aluminum, ammonium, sodium, potassium, calcium, tris(hydroxymethyl)methyl ammonium and lower alkyl of 1 through 4 carbon atoms, R is selected from the group consisting of hydrogen and lower alkyl of 1 through 4 carbon atoms, and R 1 and R 2 are selected from the group consisting of hydrogen, fluorine, chlorine, bromine, trifluoromethyl, lower alkoxy of 1 through 4 carbon atoms and lower alkyl of 1 through 4 carbon atoms, in association with a pharmaceutical carrier.
Claim 8
Dependent Claim
22 words
A process of claim 5 comprising the specific compound wherein M, R, R 1 and R 2 are hydrogen, namely, 2'-cyanooxanilic acid.
Claim 9
Dependent Claim
11 words
A method in accordance with claim 5 wherein R is hydrogen.
Claim 10
Dependent Claim
14 words
A method in accordance with claim 7 wherein the mammal needs treatment for asthma.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-10-19 | 1980-04-19 | 1980-10-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-10-19 | 1984-04-19 | 1984-10-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-10-19 | 1988-04-19 | 1988-10-19 | $7700.00 | Window Closed / Lapsed |