US3985893A
Expired / Lapsed
US
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Method for treating cardiac insufficiency with antibiotic A-23187
Assignee: Eli Lilly and Co
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Filing: 1974-10-29
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Granted: 1976-10-12
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Expires: 1994-10-29
Abstract
Abstract A method for enhancing the contractile force of mammalian heart muscle which comprises administering an effective amount of antibiotic A-23187, a divalent cation ionophore.
Inventors
- 👤 Donald R. Holland
- 👤 Mitchell I. Steinberg
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 22:41
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/41; A61K31/42
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
46 words
The method of enhancing the contractile force of mammalian heart muscle in a warm blooded mammal which comprises administering parenterally an effective non-toxic dose of between approximately 25 mcg./kg. and 500 mcg./kg. of body weight of the antibiotic A-23187 free acid or the calcium salt thereof.
Claim 2
Independent Claim
46 words
The method of enhancing the contractile force of mammalian heart muscle in a warm blooded mammal which comprises administering parenterally an effective non-toxic dose of between approximately 25 mcg./kg. and 500 mcg./kg. of body weight of the antibiotic A-23187 free acid or the calcium salt thereof.
Claim 3
Dependent Claim
14 words
The method of claim 1 wherein the dose administered is below about 100 mcg./kg.
Claim 4
Dependent Claim
14 words
The method of claim 1 wherein the free acid form of A-23187 is administered.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-10-12 | 1980-04-12 | 1980-10-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-10-12 | 1984-04-12 | 1984-10-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-10-12 | 1988-04-12 | 1988-10-12 | $7700.00 | Window Closed / Lapsed |