US3985742A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for preparing 3-hydroxymethyl cephalosporins
Assignee: Merck and Co Inc
•
Filing: 1975-02-18
•
Granted: 1976-10-12
•
Expires: 1995-02-18
Abstract
Abstract Disclosed are 7 beta -(D-5-amino-5-carboxyvaleramido)-7-methoxy-3-cephem-4-carboxylic acids which are substituted in the three position of the "cephem" nucleus by a variety of alkyl, haloalkyl or oxygen, sulfur and nitrogen containing substituents; and the salts, esters and amide derivatives thereof. Certain of the products are obtained by fermentation and others are obtained by synthetic means. The products exhibit activity against gram-negative and gram-positive bacteria.
Inventors
- 👤 Edward O. Stapley
- 👤 Justo M. Mata
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 12:10
CPC Classifications
C; C12; C12P; C12P35/00; C12P35/08; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/886; Y10S435/897
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
57 words
A method for the preparation of a salt of 7β-(D-5-amino-5-carboxyvaleramido)-3-(hydroxymethyl)-7-methoxy-3-cephem-4-carboxylic acid; which comprises treating a diester of 7β-(D-5-amino-5-carboxyvaleramido)-3-(carbamoyloxymethyl)-7-methoxy-3-cephem-4-carboxylic acid in which the 5-amino group has been blocked, with nitrosyl chloride to afford the corresponding diester of 7β-(D-5-amino-5-carboxyvaleramido)-3-(hydroxymethyl)-7-methoxy-3-cephem-4-carboxylic acid which, when subjected to catalytic hydrogenation and treatment with hydrazine hydrate in a basic solution, affords the desired product.
Claim 2
Independent Claim
57 words
A method for the preparation of a salt of 7β-(D-5-amino-5-carboxyvaleramido)-3-(hydroxymethyl)-7-methoxy-3-cephem-4-carboxylic acid; which comprises treating a diester of 7β-(D-5-amino-5-carboxyvaleramido)-3-(carbamoyloxymethyl)-7-methoxy-3-cephem-4-carboxylic acid in which the 5-amino group has been blocked, with nitrosyl chloride to afford the corresponding diester of 7β-(D-5-amino-5-carboxyvaleramido)-3-(hydroxymethyl)-7-methoxy-3-cephem-4-carboxylic acid which, when subjected to catalytic hydrogenation and treatment with hydrazine hydrate in a basic solution, affords the desired product.
References Cited (Backward Citations)
US3668202A
Cited
US3883518A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-10-12 | 1980-04-12 | 1980-10-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-10-12 | 1984-04-12 | 1984-10-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-10-12 | 1988-04-12 | 1988-10-12 | $7700.00 | Window Closed / Lapsed |