US3985727A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Aminoglycoside antibiotics
Assignee: Merck Sharp & Dohme LLC
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Filing: 1975-03-28
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Granted: 1976-10-12
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Expires: 1995-03-28
Abstract
Abstract This disclosure relates to the preparation of certain gentamine derivatives, to their use as intermediates in the preparation of certain novel pseudotrisaccharides containing a gentamine moiety, and to the use of these pseudotrisaccharides as antibacterial agents.
Inventors
- 👤 Peter J. L. Daniels
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 02:02
CPC Classifications
C; C07; C07H; C07H15/00; C07H15/18; C07H15/02; C07H15/04; C07H15/20; C07H15/22; C07H15/222; C07H15/226; C07H15/234
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
71 words
Compounds having the structural formula: ##SPC8## wherein each of R and R 1 represent hydrogen or methyl, R 2 is hydrogen or lower alkyl having less than 5 carbon atoms, and W represents hydrogen, methyl or hydroxymethyl, with the provisos that (a) when R, R 1 and R 2 are hydrogen, the 3-amino-3-deoxy sugar has other than the gluco-configuration, and (b) both R and R 1 must be hydrogen or methyl.
Claim 2
Dependent Claim
71 words
Compounds having the structural formula: ##SPC8## wherein each of R and R 1 represent hydrogen or methyl, R 2 is hydrogen or lower alkyl having less than 5 carbon atoms, and W represents hydrogen, methyl or hydroxymethyl, with the provisos that (a) when R, R 1 and R 2 are hydrogen, the 3-amino-3-deoxy sugar has other than the gluco-configuration, and (b) both R and R 1 must be hydrogen or methyl.
Claim 3
Dependent Claim
12 words
Compounds of claim 1 wherein R and R 1 are both methyl.
Claim 4
Dependent Claim
12 words
Compounds of claim 1 wherein R and R 1 are both hydrogen.
Claim 5
Dependent Claim
8 words
Compounds of claim 2 wherein W is hydrogen.
Claim 6
Dependent Claim
8 words
Compounds of claim 2 wherein W is methyl.
Claim 7
Dependent Claim
10 words
Compounds of claim 2 wherein W is CH 2 OH.
Claim 8
Dependent Claim
8 words
Compounds of claim 3 wherein W is hydrogen.
Claim 9
Dependent Claim
8 words
Compounds of claim 3 wherein W is methyl.
Claim 10
Dependent Claim
10 words
Compounds of claim 3 wherein W is CH 2 OH.
Claim 11
Dependent Claim
13 words
A compound of claim 2, said compound being 0-[3-amino-3-deoxy-α-D-glucopyranosyl-(1→6)] gentamine C 1 .
Claim 12
Dependent Claim
13 words
A compound of claim 2, said compound being 0-[3-(N-methylamino)-3-deoxy-α-D-glucopyranosyl-(1→6)] gentamine C 1 .
Claim 13
Dependent Claim
13 words
A compound of claim 2, said compound being 0-[3-amino-3-deoxy-α-D-galactopyranosyl-(1→6)] gentamine C 1 .
Claim 14
Dependent Claim
13 words
A compound of claim 2, said compound being 0-[3-(N-methylamino)-3-deoxy-α-D-galactopyranosyl-(1→6) gentamine C 1 .
Claim 15
Dependent Claim
13 words
A compound of claim 2, said compound being 0-[3-amino-3-deoxy-α-D-fucopyranosyl-(1→6)] gentamine C 1 .
Claim 16
Dependent Claim
13 words
A compound of claim 2, said compound being 0-[3-(N-methylamino)-3-deoxy-α-D-fucopyranosyl-(1→6)] gentamine C 1 .
Claim 17
Dependent Claim
13 words
A compound of claim 2, said compound being 0-[3-amino-3-deoxy-α-D-xylopyranosyl-(1→6)] gentamine C 1 .
Claim 18
Dependent Claim
13 words
A compound of claim 2, said compound being 0-[3-(N-methylamino)-3-deoxy-α-D-xylopyranosyl-(1→6)] gentamine C 1 .
Claim 19
Dependent Claim
13 words
A compound of claim 2, said compound being 0-[3-amino-3-deoxy-α-L-arabinopyranosyl-(1→6)] gentamine C 1 .
Claim 20
Dependent Claim
13 words
A compound of claim 2, said compound being 0-[3-methylamino-3-deoxy-α-L-arabinopyranosyl-(1→6)] gentamine C 1 .
Claim 21
Dependent Claim
13 words
A compound of claim 2, said compound being 0-[3-amino-3,6-dideoxy-α-D-glucopyranosyl-(1→6)] gentamine C 1 .
References Cited (Backward Citations)
US3780018A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-10-12 | 1980-04-12 | 1980-10-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-10-12 | 1984-04-12 | 1984-10-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-10-12 | 1988-04-12 | 1988-10-12 | $7700.00 | Window Closed / Lapsed |