US3985723A
Expired / Lapsed
US
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Trifluoroacetylation process
Assignee: University of Mississippi
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Filing: 1971-09-07
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Granted: 1976-10-12
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Expires: 1991-09-07
Abstract
Abstract A process for N-trifluoroacetylating an amino compound, such as an amino acid or a peptide, comprising reacting the amino compound with sym-trichlorotrifluoroacetone in a dimethyl sulfoxide solvent under substantially neutral conditions.
Inventors
- 👤 Charles A. Panetta
- 👤 Travis G. Casanova
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 18:40
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/06; C07K5/06191
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
24 words
A process for N-trifluoroacetylating an amino compound having at least one hydrogen atom at the nitrogen atom comprising reacting said amino compound with sym-trichlorotrifluoroacetone.
Claim 2
Dependent Claim
24 words
A process for N-trifluoroacetylating an amino compound having at least one hydrogen atom at the nitrogen atom comprising reacting said amino compound with sym-trichlorotrifluoroacetone.
Claim 3
Dependent Claim
17 words
A process according to claim 1, wherein said reaction is carried out in a dimethyl sulfoxide solvent.
Claim 4
Dependent Claim
16 words
A process according to claim 1, wherein said reaction is carried out under substantially neutral conditions.
Claim 5
Dependent Claim
15 words
A process according to claim 1, wherein said reaction is carried out at room temperature.
Claim 6
Dependent Claim
23 words
A process according to claim 1, wherein the molar ratio of sym-trichlorotrifluoroacetone to amino compound present in the reaction mixture is approximately 3:1.
Claim 7
Dependent Claim
14 words
A process according to claim 1, wherein said amino compound is an amino acid.
Claim 8
Dependent Claim
13 words
A process according to claim 1 wherein said amino compound is a peptide.
Claim 9
Dependent Claim
36 words
A process for N-trifluoroacetylating an amino compound having at least one hydrogen atom at the nitrogen atom comprising reacting said amino compound with sym-trichlorotrifluoroacetone in a dimethyl sulfoxide solvent at room temperature under substantially neutral conditions.
Claim 10
Dependent Claim
36 words
A process for N-trifluoroacetylating an amino compound having at least one hydrogen atom at the nitrogen atom comprising reacting said amino compound with sym-trichlorotrifluoroacetone in a dimethyl sulfoxide solvent at room temperature under substantially neutral conditions.
Claim 11
Dependent Claim
14 words
A process according to claim 8 wherein said amino compound is an amino acid.
Claim 12
Dependent Claim
13 words
A process according to claim 8 wherein said amino compound is a peptide.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-10-12 | 1980-04-12 | 1980-10-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-10-12 | 1984-04-12 | 1984-10-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-10-12 | 1988-04-12 | 1988-10-12 | $7700.00 | Window Closed / Lapsed |