US3984548A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Substituted pyrido[1,2,3,-de]-1,4-benzoxazines as bactericides
Assignee: Riker Laboratories Inc
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Filing: 1974-11-21
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Granted: 1976-10-05
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Expires: 1994-11-21
Abstract
Abstract Anti-microbial agents which are 2,3-dihydro-3-substituted-7-oxo-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acids are prepared by condensation of benzoxazines with ethoxymethylene malonate esters followed by ring closure with poly phosphoric acid and hydrolysis of the resulting esters.
Inventors
- 👤 John F. Gerster
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 05:16
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/535; A01; A01N; A01N43/00; A01N43/90
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
66 words
A method for inhibiting the growth of bacteria which comprises applying to said bacteria a bactericidally effective amount of a compound of the formula ##SPC9## wherein R 1 is hydrogen or lower alkyl, R 2 is lower alkyl, lower alkoxy, halogen or nitro, n is zero to three, and when R 2 is nitro, R 1 is methyl or ethyl; or a pharmaceutically acceptable salt thereof.
Claim 2
Independent Claim
66 words
A method for inhibiting the growth of bacteria which comprises applying to said bacteria a bactericidally effective amount of a compound of the formula ##SPC9## wherein R 1 is hydrogen or lower alkyl, R 2 is lower alkyl, lower alkoxy, halogen or nitro, n is zero to three, and when R 2 is nitro, R 1 is methyl or ethyl; or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
13 words
The method according to claim 1 wherein the compound is 10-chloro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido [1,2,3-de]-1,4-benzoxazine-6-carboxylic acid.
Claim 4
Dependent Claim
13 words
The method according to claim 1 wherein the compound is 2,3-dihydro-9-fluoro-3-methyl-7-oxo-7H-pyrid. [1,2,3-de]-1,4-benzoxazine-6-carboxylic acid.
Claim 5
Dependent Claim
13 words
The method according to claim 1 wherein the compound is 9-chloro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido [1,2,3-de]-1,4-benzoxazine-6-carboxylic acid.
Claim 6
Dependent Claim
12 words
The method according to claim 1 wherein the compound is 10-chloro-2,3-dihydro-3,8-dimethyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid.
Claim 7
Dependent Claim
13 words
The method according to claim 1 wherein the compound is 2,3-dihydro-3,10-dimethyl-7-oxo-7H-pyrido[ 1,2,3-de]-1,4-benzoxazine-6-carboxylic acid.
Claim 8
Dependent Claim
12 words
The method according to claim 1 wherein the compound is 9-chloro-2,3-dihydro-3,10-dimethyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid.
Claim 9
Dependent Claim
13 words
The method according to claim 1 wherein the compound is 2,3-dihydro-7-oxo-3,8,10-trimethyl-7H-pyrido [1,2,3-de]-1,4-benzoxazine-6-carboxylic acid.
Claim 10
Dependent Claim
13 words
The method according to claim 1 wherein the compound is 2,3-dihydro-3,9-dimethyl-7-oxo-7H-pyrido [1,2,3-de]-1,4-benzoxazine-6-carboxylic acid.
Claim 11
Independent Claim
73 words
A method for inhibiting the growth of bacteria comprising applying to said bacteria a composition comprising a conventional pharmaceutical carrier and a bactericidally effective amount of a compound of the formula ##SPC10## wherein R 1 is hydrogen or lower alkyl, R 2 is lower alkyl, lower alkoyx, halogen or nitro, n is zero to three, and when R 2 is nitro, R 1 is methyl or ethyl; or a pharmaceutically acceptable salt thereof.
Claim 12
Independent Claim
73 words
A method for inhibiting the growth of bacteria comprising applying to said bacteria a composition comprising a conventional pharmaceutical carrier and a bactericidally effective amount of a compound of the formula ##SPC10## wherein R 1 is hydrogen or lower alkyl, R 2 is lower alkyl, lower alkoyx, halogen or nitro, n is zero to three, and when R 2 is nitro, R 1 is methyl or ethyl; or a pharmaceutically acceptable salt thereof.
References Cited (Backward Citations)
US3055894A
Cited
US3551565A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-10-05 | 1980-04-05 | 1980-10-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-10-05 | 1984-04-05 | 1984-10-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-10-05 | 1988-04-05 | 1988-10-05 | $7700.00 | Window Closed / Lapsed |