← Back to Patent Explorer
US3984341A Expired / Lapsed US ⏱️ 0.0 years remaining

Iodophors and a process for their preparation

Assignee: Evonik Operations GmbH
•
Filing: 1975-01-13
•
Granted: 1976-10-05
•
Expires: 1995-01-13
📄 Original PDF 🌐 Google Patents 🔄 Sync Now

Abstract

Abstract A non-foaming iodophor having a high content of active iodine comprises the product formed by mixing while heating at about 50°-120°C for about 0.75-15 hours a reaction mixture of: I. about 10-30 weight percent of elementary iodine; and Ii. about 90-70 weight percent of an aqueous solution consisting essentially of: A. about 7-30 weight percent of at least one polycarboxylic acid, at least one polycarboxylate or mixtures of said polycarboxylic acids and polycarboxylates, having at least 65 carboxyl or carboxylate groups per 100 monomer units in the polymer chain and an average degree of polymerization (numerical average value) between about 10 and 500; B. about 0-20 weight percent of at least one alkali metal iodide, ammonium iodide, mixtures of said iodides or at least one lower, monovalent, aliphatic alcohol; C. about 0-20 weight percent of at least one non-volatile multibasic mineral acid, at least one multibasic oxycarboxylic acid, or mixtures of said acids, wherein said acids do not substantially reduce elementary iodine; and D. water in an amount sufficient so that said aqueous solution comprises 100 weight-percent. The iodophor exhibits biocidal activity.

Inventors

  • 👤 Heinz Haschke
  • 👤 Gerhard Morlock

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-25 00:19
CPC Classifications
A; A61; A61K; A61K47/00; C; C08; C08F; C08F8/00; C08L; C08L29/00; C08L33/00; C08L33/02; C01; C01B; C01B7/00; C01B7/13; C01B7/14

Claims Analysis

Total Claims: 25
Claim 1
Independent Claim 298 words
A process for the production of an iodophor, said process comprising mixing while heating a mixture of: I. about 10-30 weight percent of elementary iodine; and Ii. about 90-70 weight percent of an aqueous solution consisting essentially of: a. about 7-30 weight percent of at least one polycarboxylate having an average degree of polymerization (numerical average value) between about 10 and 500, said polycarboxylate consisting essentially of: Y + w/2 basic mole % units of the formula ##EQU1## U - W basic mole % units of the formula ##EQU2## Z basic mole % units of the formula ##EQU3## W/2 basic mole % units of the formula ##EQU4## V basic mole % units of the formula ##EQU5## wherein U equals about 5-30; V equals about 1-25; W equals 0 to U; Y equals 100 - (U + V + Z); and Z equals 0 to 20; A represents an alkali metal or hydrogen ion; R 1 signifies hydrogen, methyl, hydroxy methyl, ethyl, chlorine or bromine; R 2 and R 4 are the same or different and signify hydrogen or hydroxymethyl; R 3 and R 5 are the same or different and signify hydrogen, methyl or ethyl; and whereby the expression Y+(W/2)+2Z is larger than or equal to about 65; b. about 0-20 weight percent of at least one alkali metal iodide, ammonium iodide, mixtures of said iodides or at least one lower, monovalent, aliphatic alcohol; c. about 0-20 weight percent of at least one acid selected from the group consisting of sulfuric acid, phosphoric acid, citric acid, malic acid and tartaric acid; and d. water in an amount sufficient so that said aqueous solution comprises 100 weight percent; wherein said heating is conducted at between about 50° and 120°C for a period of time sufficient to form said iodophor.
Claim 2
Dependent Claim 298 words
A process for the production of an iodophor, said process comprising mixing while heating a mixture of: I. about 10-30 weight percent of elementary iodine; and Ii. about 90-70 weight percent of an aqueous solution consisting essentially of: a. about 7-30 weight percent of at least one polycarboxylate having an average degree of polymerization (numerical average value) between about 10 and 500, said polycarboxylate consisting essentially of: Y + w/2 basic mole % units of the formula ##EQU1## U - W basic mole % units of the formula ##EQU2## Z basic mole % units of the formula ##EQU3## W/2 basic mole % units of the formula ##EQU4## V basic mole % units of the formula ##EQU5## wherein U equals about 5-30; V equals about 1-25; W equals 0 to U; Y equals 100 - (U + V + Z); and Z equals 0 to 20; A represents an alkali metal or hydrogen ion; R 1 signifies hydrogen, methyl, hydroxy methyl, ethyl, chlorine or bromine; R 2 and R 4 are the same or different and signify hydrogen or hydroxymethyl; R 3 and R 5 are the same or different and signify hydrogen, methyl or ethyl; and whereby the expression Y+(W/2)+2Z is larger than or equal to about 65; b. about 0-20 weight percent of at least one alkali metal iodide, ammonium iodide, mixtures of said iodides or at least one lower, monovalent, aliphatic alcohol; c. about 0-20 weight percent of at least one acid selected from the group consisting of sulfuric acid, phosphoric acid, citric acid, malic acid and tartaric acid; and d. water in an amount sufficient so that said aqueous solution comprises 100 weight percent; wherein said heating is conducted at between about 50° and 120°C for a period of time sufficient to form said iodophor.
Claim 3
Dependent Claim 23 words
Process according to claim 1 wherein undissolved iodine remains at the end of the reaction and said iodine is separated from said iodophor.
Claim 4
Dependent Claim 23 words
Process according to claim 1 in which said reaction mixture is heated at a temperature above about 70°C in a closed pressure vessel.
Claim 5
Dependent Claim 28 words
Process according to claim 1 wherein said reaction mixture comprises: I. about 20-30 weight percent of elementary iodine; and Ii. about 80-70 weight percent of said aqueous solution.
Claim 6
Dependent Claim 13 words
Process according to claim 1 wherein component (a) is about 15-25 weight percent.
Claim 7
Dependent Claim 25 words
Process according to claim 1wherein component (b) comprises about 7-11 weight percent of an alkali metal iodide, ammonium iodide or a mixture of said iodides.
Claim 8
Dependent Claim 13 words
Process according to claim 1 wherein component (c) is about 7-11 weight percent.
Claim 9
Dependent Claim 18 words
Process according to claim 1 wherein said polycarboxylate has an average degree of polymerization of about 10- 300.
Claim 10
Dependent Claim 14 words
Process according to claim 8 wherein said average degree of polymerization is about 15-100.
Claim 11
Dependent Claim 48 words
Process according to claim 1 wherein V equals about 1-15; W equals 0 to about 0.3 U; Z equals 0 to about 10; A represents a hydrogen ion; R 1 and Ru signifies hydrogen or hydroxy methyl; R 2 , R 3 and R 5 are each hydrogen.
Claim 12
Dependent Claim 21 words
Process according to claim 10 wherein V equals about 1-10; W equals 0; Z equals 0; and R 1 signifies hydrogen.
Claim 13
Dependent Claim 13 words
Process according to claim 6 wherein said alkali metal iodide is sodium iodide.
Claim 14
Dependent Claim 18 words
Process according to claim 1 wherein said alcohol is a C 1 -C 3 saturated, monovalent, aliphatic alcohol.
Claim 15
Dependent Claim 16 words
Process according to claim 1 wherein said heating and mixing are conducted for about 1-10 hours.
Claim 16
Dependent Claim 285 words
An iodophor comprising the product formed by mixing while heating a mixture of: I. about 10-30 weight percent of elementary iodine; and Ii. about 90-70 weight percent of at least one polycarboxylate having an average degree of polymerization (numerical average value) between about 10 and 500, said polycarboxylate consisting essentially of: Y + w/2 basic mole % units of the formula ##STR7## U - W basic mole % units of the formula ##STR8## Z basic mole % units of the formula ##STR9## W/2basic mole % units of the formula ##STR10## V basic mole % units of the formula ##STR11## wherein U equals about 5-30; V equals about 1-25; W equals 0 to U; Y equals 100 - (U + V + Z); and Z equals 0 to 20; A represents an alkali metal or hydrogen ion; R 1 signifies hydrogen, methyl, hydroxy methyl, ethyl, chlorine or bromine; R 2 and R 4 are the same or different and signify hydrogen or hydroxymethyl; R 3 and R 5 are the same or different and signify hydrogen, methyl or ethyl; and whereby the expression Y + (W/2) + 2Z is larger than or equal to about 65; b. about 0-20 weight percent of at least one alkali metal iodide, ammonium iodide, mixtures of said iodides or at least one lower, monovalent, aliphatic alcohol; c. about 0-20 weight percent of at least one acid selected from the group consisting of sulfuric acid, phosphoric acid, citric acid, malic acid and tartaric acid; and d. water in an amount sufficient so that said aqueous solution comprises 100 weight percent; wherein said heating is conducted at between about 50°and 120° C for about 0.75 to 15 hours to form said iodophor.
Claim 17
Dependent Claim 285 words
An iodophor comprising the product formed by mixing while heating a mixture of: I. about 10-30 weight percent of elementary iodine; and Ii. about 90-70 weight percent of at least one polycarboxylate having an average degree of polymerization (numerical average value) between about 10 and 500, said polycarboxylate consisting essentially of: Y + w/2 basic mole % units of the formula ##STR7## U - W basic mole % units of the formula ##STR8## Z basic mole % units of the formula ##STR9## W/2basic mole % units of the formula ##STR10## V basic mole % units of the formula ##STR11## wherein U equals about 5-30; V equals about 1-25; W equals 0 to U; Y equals 100 - (U + V + Z); and Z equals 0 to 20; A represents an alkali metal or hydrogen ion; R 1 signifies hydrogen, methyl, hydroxy methyl, ethyl, chlorine or bromine; R 2 and R 4 are the same or different and signify hydrogen or hydroxymethyl; R 3 and R 5 are the same or different and signify hydrogen, methyl or ethyl; and whereby the expression Y + (W/2) + 2Z is larger than or equal to about 65; b. about 0-20 weight percent of at least one alkali metal iodide, ammonium iodide, mixtures of said iodides or at least one lower, monovalent, aliphatic alcohol; c. about 0-20 weight percent of at least one acid selected from the group consisting of sulfuric acid, phosphoric acid, citric acid, malic acid and tartaric acid; and d. water in an amount sufficient so that said aqueous solution comprises 100 weight percent; wherein said heating is conducted at between about 50°and 120° C for about 0.75 to 15 hours to form said iodophor.
Claim 18
Dependent Claim 17 words
Iodophor according to claim 15 wherein said polycarboxylate has an average degree of polymerization of about 10-300.
Claim 19
Dependent Claim 14 words
Iodophor according to claim 16 wherein said average degree of polymerization is about 15-100.
Claim 20
Dependent Claim 47 words
Iodophor according to claim 15 wherein V equals about 1-15; W equals 0 to about 0.3 U; Z equals 0 to about 10; A represents a hydrogen ion; R 1 and Ru hydrogen or hydroxy methyl; R 2 , R 3 and R 5 are each hydrogen.
Claim 21
Dependent Claim 21 words
Iodophor according to claim 18 wherein V equals about 1-10; W equals 0; Z equals 0; and R 1 signifies hydrogen.
Claim 22
Dependent Claim 13 words
Iodophor according to claim 18 wherein said alkali metal iodide is sodium iodide.
Claim 23
Dependent Claim 18 words
Iodophor according to claim 18 wherein said alcohol is a C 1 -C 3 saturated, monovalent, aliphatic alcohol.
Claim 24
Dependent Claim 15 words
Iodophor according to claim 15 having a content of about 7-26 weight percent active iodine.
Claim 25
Dependent Claim 22 words
Iodophor according to claim 15 having a weight ratio of active iodine to inactive iodine therein between about 16:1 and about 2:1.

References Cited (Backward Citations)

US2900305A Cited
US2987505A Cited
US3028300A Cited
US3136755A Cited
US3150096A Cited
US3367877A Cited
US3437647A Cited
US3686145A Cited
US3793222A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1979-10-05 1980-04-05 1980-10-05 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1983-10-05 1984-04-05 1984-10-05 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1987-10-05 1988-04-05 1988-10-05 $7700.00 Window Closed / Lapsed

Assigned Categories & Tags

No categories assigned to this patent yet.

Assign Category Tag