US3983228A
Expired / Lapsed
US
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Water-in-oil adjuvant composition
Assignee: Merck and Co Inc
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Filing: 1974-11-19
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Granted: 1976-09-28
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Expires: 1994-11-19
Abstract
Abstract Pure isomannide monooleate and pure aluminum monostearate are used singularly or in combination in the preparation of emulsion type adjuvant vaccines to yield an adjuvant superior to prior art adjuvants which employ commercial mannide monooleate and aluminum monostearate. Highly desirable formulations are obtained by the inclusion of pure aluminum monostearate as a stabilizer in combination with the pure isomannide monooleate.
Inventors
- 👤 Allen F. Woodhour
- 👤 Maurice R. Hilleman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 13:47
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K39/00; A61K39/12; A61K39/145; A61K39/39; A61K2039/555; A61K2039/55505; A61K2039/55511; A61K2039/55566; A61K2039/70; C; C12; C12N; C12N2760/00; C12N2760/00011; C12N2760/16011; C12N2760/16111; C12N2760/16134; C12N2760/16211; C12N2760/16234
Claims Analysis
Total Claims: 34
Claim 1
Independent Claim
18 words
An adjuvant composition comprising an oil and from about 0.5 - 10% by volume of pure isomannide monooleate.
Claim 2
Dependent Claim
18 words
An adjuvant composition comprising an oil and from about 0.5 - 10% by volume of pure isomannide monooleate.
Claim 3
Dependent Claim
13 words
The adjuvant composition of claim 1 wherein the oil is a vegetable oil.
Claim 4
Dependent Claim
13 words
The adjuvant composition of claim 1 wherein the oil is a mineral oil.
Claim 5
Dependent Claim
13 words
The adjuvant composition of claim 2 wherein the vegetable oil is peanut oil.
Claim 6
Dependent Claim
21 words
An adjuvant vaccine composition comprising an oil, an antigen and from about 0.5 - 10% by volume of pure isomannide monooleate.
Claim 7
Dependent Claim
21 words
An adjuvant vaccine composition comprising an oil, an antigen and from about 0.5 - 10% by volume of pure isomannide monooleate.
Claim 8
Dependent Claim
13 words
The adjuvant vaccine composition of claim 5 wherein the oil is vegetable oil.
Claim 9
Dependent Claim
14 words
The adjuvant vaccine composition of claim 5 wherein the oil is a mineral oil.
Claim 10
Dependent Claim
14 words
The adjuvant vaccine composition of claim 6 wherein the vegetable oil is peanut oil.
Claim 11
Dependent Claim
12 words
The adjuvant vaccine composition of claim 5 wherein the antigen is influenza.
Claim 12
Dependent Claim
12 words
The adjuvant vaccine composition of claim 6 wherein the antigen is influenza.
Claim 13
Dependent Claim
12 words
The adjuvant vaccine composition of claim 8 wherein the antigen is influenza.
Claim 14
Dependent Claim
29 words
An adjuvant composition comprising an oil, from about 0.5 - 10% by volume of pure isomannide monooleate and from about 0.5 - 10% by volume of pure aluminum monostearate.
Claim 15
Dependent Claim
29 words
An adjuvant composition comprising an oil, from about 0.5 - 10% by volume of pure isomannide monooleate and from about 0.5 - 10% by volume of pure aluminum monostearate.
Claim 16
Dependent Claim
13 words
The adjuvant composition of claim 12 wherein the oil is a vegetable oil.
Claim 17
Dependent Claim
13 words
The adjuvant composition of claim 12 wherein the oil is a mineral oil.
Claim 18
Dependent Claim
13 words
The adjuvant composition of claim 13 wherein the vegetable oil is peanut oil.
Claim 19
Dependent Claim
31 words
An adjuvant composition comprising an oil, an antigen, from about 0.5 - 10% by volume of pure isomannide monooleate and from about 0.5 - 10% by volume of pure aluminum monostearate.
Claim 20
Dependent Claim
31 words
An adjuvant composition comprising an oil, an antigen, from about 0.5 - 10% by volume of pure isomannide monooleate and from about 0.5 - 10% by volume of pure aluminum monostearate.
Claim 21
Dependent Claim
14 words
The adjuvant vaccine composition of claim 16 wherein the oil is a vegetable oil.
Claim 22
Dependent Claim
14 words
The adjuvant vaccine composition of claim 16 wherein the oil is a mineral oil.
Claim 23
Dependent Claim
14 words
The adjuvant vaccine composition of claim 17 wherein the vegetable oil is peanut oil.
Claim 24
Dependent Claim
12 words
The adjuvant vaccine composition of claim 16 wherein the antigen is influenza.
Claim 25
Dependent Claim
12 words
The adjuvant vaccine composition of claim 17 wherein the antigen is influenza.
Claim 26
Dependent Claim
12 words
The adjuvant vaccine composition of claim 19 wherein the antigen is influenza.
Claim 27
Dependent Claim
52 words
A parenteral vaccine preparation in the form of an emulsion comprising: a. a disperse aqueous phase containing at least one antigenic substance; b. a continuous oil phase; c. from about 0.5 - 10% by volume of pure isomannide monooleate and d. from about 0.5 - 10% by volume of pure aluminum monostearate.
Claim 28
Dependent Claim
52 words
A parenteral vaccine preparation in the form of an emulsion comprising: a. a disperse aqueous phase containing at least one antigenic substance; b. a continuous oil phase; c. from about 0.5 - 10% by volume of pure isomannide monooleate and d. from about 0.5 - 10% by volume of pure aluminum monostearate.
Claim 29
Dependent Claim
57 words
A parenteral vaccine preparation in the form of an emulsion comprising (A) an emulsion vehicle which contains on a volume basis: pure isomannide monooleate (0.5 - 10%), oil (90-99.5%); and (B) an aqueous phase having incorporated therein, prior to emulsification, an immunological agent in an amount sufficient to elicit immune response when parenterally administered to a host.
Claim 30
Dependent Claim
57 words
A parenteral vaccine preparation in the form of an emulsion comprising (A) an emulsion vehicle which contains on a volume basis: pure isomannide monooleate (0.5 - 10%), oil (90-99.5%); and (B) an aqueous phase having incorporated therein, prior to emulsification, an immunological agent in an amount sufficient to elicit immune response when parenterally administered to a host.
Claim 31
Dependent Claim
20 words
A process for enhancing immunity in a host comprising parenterally administering to said host the vaccine preparation of claim 24.
Claim 32
Dependent Claim
62 words
A parenteral vaccine preparation in the form of an emulsion comprising (A) an emulsion vehicle which contains on a volume basis: pure isomannide monooleate (0.5 - 10%), pure aluminum monostearate (0.5 - 10%), oil (80-99%); (B) an aqueous phase having incorporated therein, prior to emulsification, an immunological agent in an amount sufficient to elicit immune response when parenterally administered to a host.
Claim 33
Dependent Claim
62 words
A parenteral vaccine preparation in the form of an emulsion comprising (A) an emulsion vehicle which contains on a volume basis: pure isomannide monooleate (0.5 - 10%), pure aluminum monostearate (0.5 - 10%), oil (80-99%); (B) an aqueous phase having incorporated therein, prior to emulsification, an immunological agent in an amount sufficient to elicit immune response when parenterally administered to a host.
Claim 34
Dependent Claim
20 words
A process for enhancing immunity in a host comprising parenterally administering to said host the vaccine preparation of claim 26.
References Cited (Backward Citations)
US3435112A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-09-28 | 1980-03-29 | 1980-09-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-09-28 | 1984-03-29 | 1984-09-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-09-28 | 1988-03-29 | 1988-09-28 | $7700.00 | Window Closed / Lapsed |