US3983209A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for treating burns
Assignee: Alza Corp
•
Filing: 1975-01-28
•
Granted: 1976-09-28
•
Expires: 1995-01-28
Abstract
Abstract A method is disclosed for treating the burned surface of an animal by administering to said surface a contact composition comprising a hydrophobic, bioerodible polymer containing an agent selected from the group consisting of antibacterial, antibiotic, antifungal, proteolytic enzyme and mixtures thereof, which composition when placed in contact with the burned surface maintains homeostasis including prevention of tissue dehydration and thermal loss, and as the polymer bioerodes over time, releases agent to produce a continuous chemoprophylatic or chemotherapeutic effect.
Inventors
- 👤 Edward Emil Schmitt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 18:23
CPC Classifications
A; A61; A61L; A61L15/00; A61L15/16; A61L15/42; A61L15/64; A61L15/38; A61L15/44; A61L2300/00; A61L2300/20; A61L2300/252; A61L2300/254; A61L2300/40; A61L2300/404; A61L2300/406
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
94 words
A method of treating burns in animals which comprises applying to the burned surface an agent selected from the group consisting of an antibacterial, antibiotic, antifungal and proteolytic enzyme and mixtures thereof in a hydrophobic, bioerodible polymer of the formula: ##EQU1##wherein R is a lower alkyl of 1 to 7 carbons, x is 0 or 1, y is 4 to 10, z is 1 to 3 and n is 10 to 1000, which polymer on bioerosion, releases an effective amount of the agent to the thermally produced wound for the treatment of said burn.
Claim 2
Independent Claim
94 words
A method of treating burns in animals which comprises applying to the burned surface an agent selected from the group consisting of an antibacterial, antibiotic, antifungal and proteolytic enzyme and mixtures thereof in a hydrophobic, bioerodible polymer of the formula: ##EQU1##wherein R is a lower alkyl of 1 to 7 carbons, x is 0 or 1, y is 4 to 10, z is 1 to 3 and n is 10 to 1000, which polymer on bioerosion, releases an effective amount of the agent to the thermally produced wound for the treatment of said burn.
Claim 3
Dependent Claim
20 words
A method for treating burns according to claim 1 wherein the polymer has the formula: ##STR3##and the agent is 4-homosulfanilamide.
Claim 4
Dependent Claim
20 words
A method for treating burns according to claim 1 wherein the agent and the polymer are impregnated into a fabric.
Claim 5
Dependent Claim
16 words
A method for treating burns according to claim 1 wherein the polymer essentially maintains body homestasis.
Claim 6
Independent Claim
58 words
A method for preventing dehydration from an animal wound by applying to the wound a polymer of the formula: ##STR4##wherein R is a lower alkyl of 1 to 7 carbon atoms, x is 0 or 1, y is 4 to 10, z is 1 to 3 and n is 10 to 1000, to substantially prevent water vapor loss.
Claim 7
Independent Claim
58 words
A method for preventing dehydration from an animal wound by applying to the wound a polymer of the formula: ##STR4##wherein R is a lower alkyl of 1 to 7 carbon atoms, x is 0 or 1, y is 4 to 10, z is 1 to 3 and n is 10 to 1000, to substantially prevent water vapor loss.
Claim 8
Dependent Claim
16 words
A method for preventing dehydration according to claim 5 wherein the wound is exposed animal tissue.
Claim 9
Independent Claim
65 words
A method for preventing loss of animal body heat by applying to an animal wound a polymer of the formula: ##STR5## wherein R is a lower alkyl of 1 to 7 carbons, x is 0 to 1, y is 4 to 10 n is 10 to 1000 and z is an integer between 1 and 3, in an amount sufficient to substantially prevent heat loss.
Claim 10
Independent Claim
65 words
A method for preventing loss of animal body heat by applying to an animal wound a polymer of the formula: ##STR5## wherein R is a lower alkyl of 1 to 7 carbons, x is 0 to 1, y is 4 to 10 n is 10 to 1000 and z is an integer between 1 and 3, in an amount sufficient to substantially prevent heat loss.
Claim 11
Independent Claim
67 words
A method for treating topical burns of an animal by applying to the burned surface a composition comprising 4-homosulfanilamide and a proteolytic enzyme in a hydrophobic polymer of the formula: ##STR6##wherein n is 10 to 1000, which polymer bioerodes on the burned surface over a prolonged period of time and releases an effective amount of 4-homosulfanilamide for its antibacterial effect and the enzyme for debridement of eschar.
Claim 12
Independent Claim
67 words
A method for treating topical burns of an animal by applying to the burned surface a composition comprising 4-homosulfanilamide and a proteolytic enzyme in a hydrophobic polymer of the formula: ##STR6##wherein n is 10 to 1000, which polymer bioerodes on the burned surface over a prolonged period of time and releases an effective amount of 4-homosulfanilamide for its antibacterial effect and the enzyme for debridement of eschar.
Claim 13
Dependent Claim
44 words
A method for treating burns according to claim 1 wherein the antibacterial agent is a member selected from the group consisting of sodium sulfacetamide, silver sulfadiazine, sulfadimethoxine, sulfaethiodole, sulfamethazine, aminosalicylic acid, sulfamethizole, sulfamethoxazole, sulfapyridine, cetylpyridinium chloride, silver nitrate, 5-chloro-3-tri-fluoromethyl salicylanilide, 4-methyl-benzimidazolone chlorhexidine and hexachlorophene.
Claim 14
Dependent Claim
44 words
A method for treating burns according to claim 1 wherein the antibiotic agent is a member selected from the group consisting of bacitracin, zinc bacitracin, chlortetracycline monohydrochloride, colistin sulfate, cycloserine, erythromycin, chloramphenicol, gentamicin sulfate, neomycin sulfate, polymyxin sulfate, ampicillin, sodium cephalothin, penicillin and lincomycin.
Claim 15
Dependent Claim
30 words
A method for treating burns according to claim 8 wherein the enzyme is a member selected from the group consisting of papain, trypsin, collagenase, subitilisin, pepsin, lysozyme, streptokinase and fibrinolysin.
Claim 16
Independent Claim
102 words
A method for treating burns in a mammal which comprises applying to the burn of the mammal a polymer of the general formula: ##STR7##wherein R is a lower alkyl of 1 to 7 carbons, x is 0 or 1, y is 4 to 10, z is 1 to 3 and n is 10 to 1000, which polymer contains an effective amount of a member selected from the group consisting of antibacterial, antibiotic, antifungal and proteolytic enzyme agents, which agent is released on bioerosion of the polymer to the burn of the mammal in a therapeutically effective amount to produce a beneficial effect.
Claim 17
Independent Claim
102 words
A method for treating burns in a mammal which comprises applying to the burn of the mammal a polymer of the general formula: ##STR7##wherein R is a lower alkyl of 1 to 7 carbons, x is 0 or 1, y is 4 to 10, z is 1 to 3 and n is 10 to 1000, which polymer contains an effective amount of a member selected from the group consisting of antibacterial, antibiotic, antifungal and proteolytic enzyme agents, which agent is released on bioerosion of the polymer to the burn of the mammal in a therapeutically effective amount to produce a beneficial effect.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-09-28 | 1980-03-29 | 1980-09-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-09-28 | 1984-03-29 | 1984-09-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-09-28 | 1988-03-29 | 1988-09-28 | $7700.00 | Window Closed / Lapsed |