US3983138A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Amino acid esters
Assignee: Merck and Co Inc
•
Filing: 1974-06-25
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Granted: 1976-09-28
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Expires: 1994-06-25
Abstract
Abstract Derivatives of alpha -methyl-3,4-dihydroxyphenylalanine which are useful in compositions as anti-hypertensive agents.
Inventors
- 👤 Walfred S. Saari
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 11:13
CPC Classifications
C; C07; C07D; C07D207/00; C07D207/02; C07D207/30; C07D207/34; C07D207/36; C07D207/40; C07D207/404; A; A61; A61P; A61P9/00; A61P9/12; C07D207/44; C07D207/444; C07D207/448; C07D207/452; C07D209/00; C07D209/02; C07D209/44; C07D209/48; C07D211/00; C07D211/04; C07D211/80; C07D211/84; C07D211/86; C07D211/88; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/78; C07D213/81; C07D213/82; C07D233/00; C07D233/54; C07D233/64; C07D233/66; C07D263/00; C07D263/02; C07D263/30; C07D263/34; C07D263/44; C07D275/00; C07D275/04; C07D275/06; C07D317/00; C07D317/08; C07D317/44; C07D317/46; C07D317/48; C07D317/50; C07D317/60
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
63 words
A compound of the formula: ##SPC17## wherein n is 0, 1, 2 or 3; m is 0, 1, 2 or 3; A 1 and A 2 are individually H or a lower alkanoyl group R 1 and R 2 are individually H or alkyl of 1 to 3 carbon atoms and; R 3 is succinimido; or a pharmaceutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
63 words
A compound of the formula: ##SPC17## wherein n is 0, 1, 2 or 3; m is 0, 1, 2 or 3; A 1 and A 2 are individually H or a lower alkanoyl group R 1 and R 2 are individually H or alkyl of 1 to 3 carbon atoms and; R 3 is succinimido; or a pharmaceutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
9 words
A free base of the compound of claim 1.
Claim 4
Dependent Claim
12 words
A pharmaceutically acceptable acid addition salt of the compound of claim 1.
Claim 5
Dependent Claim
23 words
A compound of claim 1 wherein n and m are 0, R 1 and R 2 are hydrogen and R 3 is ##SPC18##
Claim 6
Dependent Claim
11 words
The hydrochloric acid addition salt of the compound of claim 4.
Claim 7
Dependent Claim
24 words
A compound of claim 1 wherein n and m are 0, R 1 is methyl, R 2 is hydrogen and R 3 is ##SPC19##
Claim 8
Dependent Claim
11 words
The hydrochloric acid addition salt of the compound of claim 6.
Claim 9
Dependent Claim
64 words
An ester of the L isomer of an amino acid, substantially free of the D isomer, having the formula: ##SPC20## wherein n is 0, 1, 2 or 3; m is 0, 1, 2 or 3; R 1 and R 2 are individually H or alkyl of 1 to 3 carbon atoms and; R 3 is succinimido; or a pharmaceutically acceptable acid addition salt thereof.
Claim 10
Dependent Claim
64 words
An ester of the L isomer of an amino acid, substantially free of the D isomer, having the formula: ##SPC20## wherein n is 0, 1, 2 or 3; m is 0, 1, 2 or 3; R 1 and R 2 are individually H or alkyl of 1 to 3 carbon atoms and; R 3 is succinimido; or a pharmaceutically acceptable acid addition salt thereof.
Claim 11
Dependent Claim
9 words
A free base of the ester of claim 8.
Claim 12
Dependent Claim
12 words
A pharmaceutically acceptable acid addition salt of the ester of claim 8.
Claim 13
Dependent Claim
23 words
An ester of claim 8 wherein n and m are 0, R 1 and R 2 are hydrogen and R 3 is ##SPC21##
Claim 14
Dependent Claim
11 words
The hydrochloric acid addition salt of the ester of claim 8.
Claim 15
Dependent Claim
24 words
The ester of claim 8 wherein n and m are 0, R 1 is methyl, R 2 is hydrogen and R 3 is ##SPC22##
Claim 16
Dependent Claim
11 words
The hydrochloric acid addition salt of the ester of claim 13.
Claim 17
Dependent Claim
12 words
The compound α-succinimidopropyl L-3-(3,4-dihydroxyphenyl)-2-methylalaninate, or a pharmaceutically acceptable acid addition salt thereof.
Claim 18
Dependent Claim
12 words
The compound α-succinimidopropyl L-3-(3,4-dihydroxyphenyl)-2-methylalaninate, or a pharmaceutically acceptable acid addition salt thereof.
Claim 19
Dependent Claim
12 words
The compound succinimidomethyl L-3-(3,4-dihydroxyphenyl)-2-methylalaninate, or a pharmaceutically acceptable acid addition salt thereof.
Claim 20
Dependent Claim
12 words
The compound succinimidomethyl L-3-(3,4-dihydroxyphenyl)-2-methylalaninate, or a pharmaceutically acceptable acid addition salt thereof.
Claim 21
Dependent Claim
12 words
The compound α-succinimidoethyl L-3-(3,4-dihydroxyphenyl)-2-methylalaninate; or a pharmaceutically acceptable acid addition salt thereof.
Claim 22
Dependent Claim
12 words
The compound α-succinimidoethyl L-3-(3,4-dihydroxyphenyl)-2-methylalaninate; or a pharmaceutically acceptable acid addition salt thereof.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-09-28 | 1980-03-29 | 1980-09-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-09-28 | 1984-03-29 | 1984-09-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-09-28 | 1988-03-29 | 1988-09-28 | $7700.00 | Window Closed / Lapsed |