US3983121A
Expired / Lapsed
US
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1-Substituted 4-(β-2-quinolylethyl)piperazines and 1,2,3,4-tetrahydroquinolyl-ethyl analogues thereof
Assignee: Council of Scientific and Industrial Research
•
Filing: 1974-07-01
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Granted: 1976-09-28
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Expires: 1994-07-01
Abstract
Abstract Pharmacologically active 1-substituted 4-(β-2-quinolylethyl)piperazines of the formula ##SPC1## And their 1,2,3,4-tetrahydroquinolylethyl analogues, wherein R represents a lower alkyl, a phenyl, benzyl or a phenethyl group; and pharmaceutically acceptable acid addition and quaternary ammonium salts thereof.
Inventors
- 👤 Varanasi Aruna Murthi
- 👤 Padam Chand Jain
- 👤 Jitendra Nath Sharma
- 👤 Rikhab Chand Srimal
- 👤 Bhola Nath Dhawan
- 👤 Nitya Anand
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 15:13
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/02; C07D401/06
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
41 words
A compound which is a member of the group consisting of: 1-(m-tolyl)-4-(β-2-quinolylethyl)piperazine, 1-(m-tolyl)-4-(β-2-quinolylethyl)piperazine hydrochloride, 1-(m-tolyl)-4-[β-2-(1,2,3,4-tetrahydroquinolyl)ethyl]piperazine, 1-(m-tolyl)-4-[β-2-(1,2,3,4-tetrahydroquinolyl)-ethyl]piperazine hydrochloride, 1-(o-tolyl)-4-(β-2-quinolylethyl)piperazine, 1-(p-tolyl)-4-(β-2-quinolylethyl)piperazine, 1-phenyl-4-(β-2-quinolylethyl)piperazine, 1-(p-methoxyphenyl)-4-(β-2-quinolylethyl)piperazine, 1-(o-methoxyphenyl)-4-(β-2-quinolylethyl)piperazine, 1-(2,5-xylyl)-4-(β-2-quinolylethyl)piperazine, 1-(p-chlorophenyl)-4-(β-2-quinolylethyl)piperazine, 1-methyl-4-(β-2-quinolylethyl)piperazine, 1-(o-chlorophenyl)-4-(β-2-quinolylethyl)piperazine, 1-(m-chlorophenyl)-4-(β-2-quinolylethyl)piperazine, 1-(m-trifluoromethylphenyl)-4-(β-2-quinolylethyl)piperazine, 1-(3,4-dichlorophenyl)-4-(β-2-quinolylethyl)piperazine, 1-(2,4-xylyl)-4-(β-2-quinolylethyl)piperazine, 1-(3,4-xylyl)-4-(β-2-quinolylethyl)piperazine, 1-(β-phenethyl)-4-(β-2-quinolylethyl)piperazine, 1-(o-fluorophenyl)-4-(β-2-quinolylethyl)piperazine, 1-(m-fluorophenyl)-4-(β-2-quinolylethyl)piperazine, 1-(p-fluorophenyl)-4-(β-2-quinolylethyl)piperazine, 1-benzyl-4-(β-2-quinolylethyl)piperazine, 1-(m-tolyl)-4-[β-2-(1,2,3,4-tetrahydroquinolylethyl)]piperazine, 1-(o-tolyl)-4-[β-2-(1,2,3,4-tetrahydroquinolylethyl)]piperazine, 1-(p-tolyl)-4-[β-2-(1,2,3,4-tetrahydroquinolylethyl)]piperazine and 1-(p-methoxyphenyl)-4-[β-2-(1,2,3,4-tetrahydroquinolylethyl)]piperazine.
Claim 2
Dependent Claim
41 words
A compound which is a member of the group consisting of: 1-(m-tolyl)-4-(β-2-quinolylethyl)piperazine, 1-(m-tolyl)-4-(β-2-quinolylethyl)piperazine hydrochloride, 1-(m-tolyl)-4-[β-2-(1,2,3,4-tetrahydroquinolyl)ethyl]piperazine, 1-(m-tolyl)-4-[β-2-(1,2,3,4-tetrahydroquinolyl)-ethyl]piperazine hydrochloride, 1-(o-tolyl)-4-(β-2-quinolylethyl)piperazine, 1-(p-tolyl)-4-(β-2-quinolylethyl)piperazine, 1-phenyl-4-(β-2-quinolylethyl)piperazine, 1-(p-methoxyphenyl)-4-(β-2-quinolylethyl)piperazine, 1-(o-methoxyphenyl)-4-(β-2-quinolylethyl)piperazine, 1-(2,5-xylyl)-4-(β-2-quinolylethyl)piperazine, 1-(p-chlorophenyl)-4-(β-2-quinolylethyl)piperazine, 1-methyl-4-(β-2-quinolylethyl)piperazine, 1-(o-chlorophenyl)-4-(β-2-quinolylethyl)piperazine, 1-(m-chlorophenyl)-4-(β-2-quinolylethyl)piperazine, 1-(m-trifluoromethylphenyl)-4-(β-2-quinolylethyl)piperazine, 1-(3,4-dichlorophenyl)-4-(β-2-quinolylethyl)piperazine, 1-(2,4-xylyl)-4-(β-2-quinolylethyl)piperazine, 1-(3,4-xylyl)-4-(β-2-quinolylethyl)piperazine, 1-(β-phenethyl)-4-(β-2-quinolylethyl)piperazine, 1-(o-fluorophenyl)-4-(β-2-quinolylethyl)piperazine, 1-(m-fluorophenyl)-4-(β-2-quinolylethyl)piperazine, 1-(p-fluorophenyl)-4-(β-2-quinolylethyl)piperazine, 1-benzyl-4-(β-2-quinolylethyl)piperazine, 1-(m-tolyl)-4-[β-2-(1,2,3,4-tetrahydroquinolylethyl)]piperazine, 1-(o-tolyl)-4-[β-2-(1,2,3,4-tetrahydroquinolylethyl)]piperazine, 1-(p-tolyl)-4-[β-2-(1,2,3,4-tetrahydroquinolylethyl)]piperazine and 1-(p-methoxyphenyl)-4-[β-2-(1,2,3,4-tetrahydroquinolylethyl)]piperazine.
Claim 3
Dependent Claim
10 words
The compound of claim 1 wherein the compound is 1-(m-tolyl)-4-(β-2-quinolylethyl)piperazine.
Claim 4
Dependent Claim
11 words
The compound of claim 1 wherein the compound is 1-(m-tolyl)-4-(β-2-quinolylethyl)piperazine hydrochloride.
Claim 5
Dependent Claim
10 words
The compound of claim 1 wherein the compound is 1-(m-tolyl)-4-[β-2-(1,2,3,4-tetrahydroquinolyl)ethyl]piperazine.
Claim 6
Dependent Claim
11 words
The compound of claim 1 wherein the compound is 1-(m-tolyl)-4-[β-2-(1,2,3,4-tetrahydroquinolyl)ethyl]piperazine hydrochloride.
Claim 7
Dependent Claim
10 words
The compound of claim 1 wherein the compound is 1-(o-tolyl)-4-(β-2-quinolylethyl)piperazine.
Claim 8
Dependent Claim
10 words
The compound of claim 1 wherein the compound is 1-(p-tolyl-4-(β-2-quinolylethyl)piperazine.
Claim 9
Dependent Claim
10 words
The compound of claim 1 wherein the compound is 1-phenyl-4-(β-2-quinolylethyl)piperazine.
Claim 10
Dependent Claim
10 words
The compound of claim 1 wherein the compound is 1-(p-methoxyphenyl)-4-(β-2-quinolylethyl)piperazine.
Claim 11
Dependent Claim
10 words
The compound of claim 1 wherein the compound is 1-(o-methoxyphenyl)-4-(β-2-quinolylethyl)piperazine.
Claim 12
Dependent Claim
10 words
The compound of claim 1 wherein the compound is 1-(2,5-xylyl)-4-(β-2-quinolylethyl)piperazine.
Claim 13
Dependent Claim
10 words
The compound of claim 1 wherein the compound is 1-(p-chlorophenyl)-4-(β-2-quinolylethyl)piperazine.
Claim 14
Dependent Claim
10 words
The compound of claim 1 wherein the compound is 1-methyl-4-(β-2-quinolylethyl)piperazine.
Claim 15
Dependent Claim
10 words
The compound of claim 1 wherein the compound is 1-(o-chlorophenyl)-4-(β-2-quinolylethyl)piperazine.
Claim 16
Dependent Claim
10 words
The compound of claim 1 wherein the compound is 1-(m-chlorophenyl)-4-(β-2-quinolylethyl)piperazine.
Claim 17
Dependent Claim
10 words
The compound of claim 1 wherein the compound is 1-(m-trifluoromethylphenyl)-4-(β-2-quinolylethyl)piperazine.
Claim 18
Dependent Claim
10 words
The compound of claim 1 wherein the compound is 1-(3,4-dichlorophenyl)-4-(β-2-quinolylethyl)piperazine.
Claim 19
Dependent Claim
10 words
The compound of claim 1 wherein the compound is 1-(2,4-xylyl)-4-(β-2-quinolylethyl)piperazine.
Claim 20
Dependent Claim
10 words
The compound of claim 1 wherein the compound is 1-(3,4-xylyl)-4-(β-2-quinolylethyl)piperazine.
Claim 21
Dependent Claim
10 words
The compound of claim 1 wherein the compound is 1-(β-phenethyl)-4-(β-2-quinolylethyl)piperazine.
Claim 22
Dependent Claim
10 words
The compound of claim 1 wherein the compound is 1-(o-fluorophenyl)-4-(β-2-quinolylethyl)piperazine.
Claim 23
Dependent Claim
10 words
The compound of claim 1 wherein the compound is 1-(m-fluorophenyl)-4-(β-2-quinolylethyl)piperazine.
Claim 24
Dependent Claim
10 words
The compound of claim 1 wherein the compound is 1-(p-fluorophenyl)-4-(β-2-quinolylethyl)piperazine.
Claim 25
Dependent Claim
10 words
The compound of claim 1 wherein the compound is 1-benzyl-4-(β-2-quinolylethyl)piperazine.
Claim 26
Dependent Claim
10 words
The compound of claim 1 wherein the compound is 1-(m-tolyl)-4-[β-2-(1,2,3,4-tetrahydroquinolylethyl)]piperazine.
Claim 27
Dependent Claim
11 words
The compound of claim 1 wherein the compound is 1-(o-tolyl)-4-[β-2-(1,2,3,4-tetrahydroquinolylethyl)] piperazine.
Claim 28
Dependent Claim
10 words
The compound of claim 1 wherein the compound is 1-(p-tolyl)-4-[β-2-(1,2,3,4-tetrahydroquinolylethyl)]piperazine.
Claim 29
Dependent Claim
10 words
The compound of claim 1 wherein the compound is 1-(p-methoxyphenyl)-4-[β-2-(1,2,3,4-tetrahydroquinolylethyl)]piperazine.
References Cited (Backward Citations)
US3362956A
Cited
US3821228A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-09-28 | 1980-03-29 | 1980-09-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-09-28 | 1984-03-29 | 1984-09-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-09-28 | 1988-03-29 | 1988-09-28 | $7700.00 | Window Closed / Lapsed |