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US3983099A Expired / Lapsed US ⏱️ 0.0 years remaining

Thyroxine-and triiodothyronine-tyrosine dipeptide derivatives

Assignee: ICN Micromedic Systems Inc
•
Filing: 1975-03-19
•
Granted: 1976-09-28
•
Expires: 1995-03-19
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Abstract

Abstract The present invention is concerned with the production of novel derivatives of thyroid hormones which are useful in the radioimmunoassay (RIA) of such hormones. The invention is particularly concerned with derivatives of thyroxine and triiodothyronine which contain an additional phenol group which is readily iodinatable so that the phenol conjugate can be readily tagged with a radioactive iodine isotope, such as 125 I or 131 I, without detrimentally interfering with the ability of the tagged conjugate so competitively bind with the naturally occurring thyroid hormone in the biological liquid to be analyzed by RIA technique. The invention is also concerned with the iodine-tagged derivatives or conjugates.

Inventors

  • 👤 Gordon Dean Niswender

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-30 16:48
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/06; C07K5/06191; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/74; G01N33/78

Claims Analysis

Total Claims: 9
Claim 1
Independent Claim 55 words
A compound of the formula ##SPC4## wherein X is H, I, 125 I, or 131 I, R is a group selected from the group consisting of ##EQU1## wherein R° is an alkyl group, and b. an alkylene group, Y is H; 125 I, or 131 I, and Z is H; 125 I, or 131 I.
Claim 2
Dependent Claim 55 words
A compound of the formula ##SPC4## wherein X is H, I, 125 I, or 131 I, R is a group selected from the group consisting of ##EQU1## wherein R° is an alkyl group, and b. an alkylene group, Y is H; 125 I, or 131 I, and Z is H; 125 I, or 131 I.
Claim 3
Dependent Claim 13 words
A compound according to claim 1 in which R° is a butyl group.
Claim 4
Dependent Claim 13 words
A compound according to claim 1 in which R is an ethylene group.
Claim 5
Dependent Claim 14 words
A compound according to claim 1 wherein X is I and R is ##STR13##
Claim 6
Dependent Claim 15 words
A compound according to claim 4 wherein at least one Y or Z radical is
Claim 7
Dependent Claim 15 words
A compound according to claim 6 wherein at least one of the Y and Z
Claim 8
Dependent Claim 15 words
A compound according to claim 2 wherein at least one of the Y and Z
Claim 9
Dependent Claim 22 words
A compound according to claim 3 wherein at least one of the Y and Z radicals is 125 I or 131 I.

References Cited (Backward Citations)

US3715434A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1979-09-28 1980-03-29 1980-09-28 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1983-09-28 1984-03-29 1984-09-28 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1987-09-28 1988-03-29 1988-09-28 $7700.00 Window Closed / Lapsed

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