US3981887A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Sulfoxides and sulfones
Assignee: Merck Patent GmbH
•
Filing: 1974-07-31
•
Granted: 1976-09-21
•
Expires: 1994-07-31
Abstract
Abstract Sulfoxides and sulfones of the formula ##SPC1## Wherein R 1 is COOH, COOR 4 , CH 2 OH, or CH 2 OR 5 ; R 2 is CH 3 or C 2 H 5 ; R 3 is H, F, Cl, or Br; R 4 is alkyl of 1-8 carbon atoms; R 5 is alkanoyl of 2-4 carbon atoms; one of the Y groups is SO or SO 2 and the other Y group is CH 2 , O, S, SO, or SO 2 ; and the physiologically acceptable salts thereof, which compounds possess anti-inflammatory activity, can be produced by converting in a compound of the formula ##SPC2## Wherein X is a group convertible into the group --CHR 1 R 2 wherein R 1 , R 2 , R 3 , and Y have the values given above, the group X into the group --CHR 1 R 3 .
Inventors
- 👤 Joachim Gante
- 👤 Hans-Adolf Kurmeier
- 👤 Werner Mehrhof
- 👤 Albrecht Wild
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 02:37
CPC Classifications
C; C07; C07D; C07D339/00; C07D339/08; C07D327/00; C07D327/02; C07D327/06; C07D327/08
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
96 words
A compound of the formula ##SPC7## wherein R 1 is COOH, COOR 4 , CH 2 OH or CH 2 OR 5 ; R 2 is CH 3 or C 2 H 5 ; R 3 is F, Cl or Br; R 4 is alkyl of 1-8 carbon atoms; R 5 is alkanoyl of 2-4 carbon atoms; one of the Y groups is SO or SO 2 and the other Y group is CH 2 , O, S, SO or SO 2 ; or a physiologically acceptable salt of those compounds wherein R 1 is COOH.
Claim 2
Dependent Claim
96 words
A compound of the formula ##SPC7## wherein R 1 is COOH, COOR 4 , CH 2 OH or CH 2 OR 5 ; R 2 is CH 3 or C 2 H 5 ; R 3 is F, Cl or Br; R 4 is alkyl of 1-8 carbon atoms; R 5 is alkanoyl of 2-4 carbon atoms; one of the Y groups is SO or SO 2 and the other Y group is CH 2 , O, S, SO or SO 2 ; or a physiologically acceptable salt of those compounds wherein R 1 is COOH.
Claim 3
Dependent Claim
55 words
A compound of the formula ##SPC8## wherein R 1 is COOH or a physiologically acceptable salt thereof; R 2 is CH 3 or C 2 H 5 ; R 3 is H, F, Cl or Br; one of the Y groups is SO or SO 2 and the other Y group is CH 2 .
Claim 4
Dependent Claim
55 words
A compound of the formula ##SPC8## wherein R 1 is COOH or a physiologically acceptable salt thereof; R 2 is CH 3 or C 2 H 5 ; R 3 is H, F, Cl or Br; one of the Y groups is SO or SO 2 and the other Y group is CH 2 .
Claim 5
Dependent Claim
9 words
A compound of Claim 2, claim 2-(2-thioxanthenyl)-propionic acid 10,10-dioxide.
Claim 6
Dependent Claim
53 words
A compound of the formula ##SPC9## wherein R 1 is COOH or a physiologically acceptable salt thereof; R 2 is CH 3 or C 2 H 5 ; R 3 is H, F, Cl or Br; one of the Y groups is SO or SO 2 and the other Y group is O.
Claim 7
Dependent Claim
53 words
A compound of the formula ##SPC9## wherein R 1 is COOH or a physiologically acceptable salt thereof; R 2 is CH 3 or C 2 H 5 ; R 3 is H, F, Cl or Br; one of the Y groups is SO or SO 2 and the other Y group is O.
Claim 8
Dependent Claim
8 words
A compound of claim 4, 2-(2-phenoxathiinyl)-propionic acid 10-oxide.
Claim 9
Dependent Claim
8 words
A compound of claim 4, 2-(2-phenoxathiinyl)-propionic acid 10,10-dioxide.
Claim 10
Dependent Claim
8 words
A compound of claim 4, 2-(8-bromo-2-phenoxathiinyl)-propionic acid 10,10-dioxide.
Claim 11
Dependent Claim
57 words
A compound of the formula ##SPC10## wherein R 1 is COOR 4 ; R 2 is CH 3 or C 2 H 5 ; R 3 is H, F, Cl or Br; R 4 is alkyl of 1-8 carbon atoms; one of the Y groups is SO or SO 2 and the other Y group is O.
Claim 12
Dependent Claim
57 words
A compound of the formula ##SPC10## wherein R 1 is COOR 4 ; R 2 is CH 3 or C 2 H 5 ; R 3 is H, F, Cl or Br; R 4 is alkyl of 1-8 carbon atoms; one of the Y groups is SO or SO 2 and the other Y group is O.
Claim 13
Dependent Claim
10 words
A compound of claim 8, 2-(2-phenoxathiinyl)-propionic acid ethyl ester 10,10-dioxide.
References Cited (Backward Citations)
US3639612A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-09-21 | 1980-03-22 | 1980-09-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-09-21 | 1984-03-22 | 1984-09-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-09-21 | 1988-03-22 | 1988-09-21 | $7700.00 | Window Closed / Lapsed |