US3980764A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Polymeric competitive protein binding adsorbents for radioassey
Assignee: Curtis Nuclear Corp
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Filing: 1973-11-05
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Granted: 1976-09-14
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Expires: 1993-11-05
Abstract
Abstract Serum protein comprising specific binding proteins such as antibodies, B 12 intrinsic factor, thyroxin binding globulin and the like may be copolymerized with globulin constituents of serum by the action of ethylchloroformate to form readily packed insoluble precipitates which, following purification as by washing, are eminently suited for employment as competitive binding protein absorbents in radioassay procedures.
Inventors
- 👤 Raymond J. Adams
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:15
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/531; C; C07; C07K; C07K16/00; C07K16/18; C07K16/26; Y; Y10; Y10S; Y10S436/00; Y10S436/815; Y10S436/817; Y10S530/00; Y10S530/827; Y10S530/829; Y10S530/83; Y10S530/831
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
43 words
A tablet useful in radioassay for detecting the presence of a serum constituent comprising in minor effective radioassay proportion a specific adsorbent for said serum consituent comprising a copolymer of globulin and, as a comonomer, a specific binding protein for said serum constituent.
Claim 2
Dependent Claim
43 words
A tablet useful in radioassay for detecting the presence of a serum constituent comprising in minor effective radioassay proportion a specific adsorbent for said serum consituent comprising a copolymer of globulin and, as a comonomer, a specific binding protein for said serum constituent.
Claim 3
Dependent Claim
27 words
A tablet according to claim 1 which additionally comprises a minor radioassay effective proportion of a radioactive marker competitive with said constituent in binding to said protein.
Claim 4
Dependent Claim
26 words
A tablet according to claim 1 wherein said specific binding protein comonomer comprises B 12 intrinsic factor and wherein said globulin is 7 S gamma globulin.
Claim 5
Dependent Claim
12 words
A tablet according to claim 1 wherein said adsorbent is a radioimmunoadsorbent.
Claim 6
Dependent Claim
19 words
A tablet according to claim 1 wherein said adsorbent is a radioimmunoadsorbent and wherein said globulin is gamma globulin.
Claim 7
Dependent Claim
37 words
A tablet according to claim 1 wherein said globulin is 7 S gamma globulin and wherein said specific binding protein comonomer comprises antibody to one of the group consisting of insulin, human growth hormone, digoxin and digitoxin.
Claim 8
Dependent Claim
27 words
A tablet according to claim 6 which additionally comprises a minor radioassay effective proportion of a radioactive marker competitive with said constituent in binding to said protein.
Claim 9
Dependent Claim
38 words
A specific adsorbent useful for detecting by radioassay the presence of vitamin B 12 comprising a copolymer of globulin and a protein comonomer comprising vitamin B 12 intrinsic factor, the latter comonomer being employed in effective radioassay amount.
Claim 10
Dependent Claim
38 words
A specific adsorbent useful for detecting by radioassay the presence of vitamin B 12 comprising a copolymer of globulin and a protein comonomer comprising vitamin B 12 intrinsic factor, the latter comonomer being employed in effective radioassay amount.
Claim 11
Dependent Claim
12 words
An adsorbent according to claim 8 wherein said globulin is gamma globulin.
Claim 12
Dependent Claim
57 words
A specific adsorbent useful for detecting by radioassay an antigen selected from the group consisting of insulin, human growth hormone, digoxin and digitoxin comprising a copolymer of globulin and a protein comonomer selected from the group consisting of the antibodies to insulin, human growth hormone, digoxin and digitoxin, the latter comonomer being employed in effective radioassay amount.
Claim 13
Dependent Claim
57 words
A specific adsorbent useful for detecting by radioassay an antigen selected from the group consisting of insulin, human growth hormone, digoxin and digitoxin comprising a copolymer of globulin and a protein comonomer selected from the group consisting of the antibodies to insulin, human growth hormone, digoxin and digitoxin, the latter comonomer being employed in effective radioassay amount.
References Cited (Backward Citations)
US2957808A
Cited
US3410839A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-09-14 | 1980-03-15 | 1980-09-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-09-14 | 1984-03-15 | 1984-09-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-09-14 | 1988-03-15 | 1988-09-14 | $7700.00 | Window Closed / Lapsed |