US3979260A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Production of deacetoxycephalosporin C
Assignee: Takeda Pharmaceutical Co Ltd
•
Filing: 1974-06-14
•
Granted: 1976-09-07
•
Expires: 1994-06-14
Abstract
Abstract Deacetoxycephalosporin C can be produced with advantage by fermentation of a microorganism which belongs to the genus Streptomyces, Cephalosporium, Emericellopsis, Paecilomyces, Anixiopsis, Arachnomyces or Spriroidium and is capable of producing deacetoxycephalosporin C. Deacetoxycephalosporin C is a useful antibiotic as such or can be used as a starting material for the production of other various cephalosporin antibiotics.
Inventors
- 👤 Yoshio Nakao
- 👤 Kazuaki Kitano
- 👤 Kazuhiko Kintaka
- 👤 Shigeru Suzuki
- 👤 Kazuyoshi Katamoto
- 👤 Kiyoshi Nara
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 22:34
CPC Classifications
C; C12; C12P; C12P35/00; C12P35/06; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/886; Y10S435/897; Y10S435/898; Y10S435/911; Y10S435/925; Y10S435/926
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
95 words
A method for producing deacetoxycephalosporin C which comprises cultivating Streptomyces griseus, Streptomyces hygroscopicus, Cephalosporium acremonium K-186 (ATCC-20416) Emericellopsis microspora K-163 (ATCC-20422), Paecilomyces carneus C-2237 (ATCC-20417), Paecilomyces carneus C-4053 (IFO-9730), Paecilomyces persicinus C-3009 (ATCC-20418), a microorganism of the genus Anixiopsis, a microorganism of the genus Arachnomyces or a microorganism of the genus Spiroidium, which is capable of producing deacetoxycephalosporin C, in a culture medium containing an assimilable carbon source and a digestible nitrogen source until deacetoxycephalosporin C is accumulated in a substantial amount in the cultured broth, and recovering the accumulated deacetoxycephalosporin C from the broth.
Claim 2
Independent Claim
95 words
A method for producing deacetoxycephalosporin C which comprises cultivating Streptomyces griseus, Streptomyces hygroscopicus, Cephalosporium acremonium K-186 (ATCC-20416) Emericellopsis microspora K-163 (ATCC-20422), Paecilomyces carneus C-2237 (ATCC-20417), Paecilomyces carneus C-4053 (IFO-9730), Paecilomyces persicinus C-3009 (ATCC-20418), a microorganism of the genus Anixiopsis, a microorganism of the genus Arachnomyces or a microorganism of the genus Spiroidium, which is capable of producing deacetoxycephalosporin C, in a culture medium containing an assimilable carbon source and a digestible nitrogen source until deacetoxycephalosporin C is accumulated in a substantial amount in the cultured broth, and recovering the accumulated deacetoxycephalosporin C from the broth.
Claim 3
Dependent Claim
14 words
A method according to claim 1, wherein the cultivation temperature is 18° to 40°C.
Claim 4
Dependent Claim
17 words
A method according to claim 1, wherein the pH of the culture medium is 2 to 10.
Claim 5
Dependent Claim
16 words
A method according to claim 1, wherein the medium contains cysteine, cystine or a mixture thereof.
Claim 6
Dependent Claim
11 words
A method according to claim 1, wherein the medium contains methionine.
Claim 7
Dependent Claim
44 words
A method according to claim 4, wherein the cultivation is carried out with Paecilomyces carneus C-2237 (ATCC-20417), Paecilomyces carneus C-4053 (IFO-9730), Paecilomyces persicinus C-3009 (ATCC-20418), a microorganism of the genus Anixiopsis, a microorgansim of the genus Arachnomyces or a microorganism of the genus Spiroidium.
Claim 8
Dependent Claim
26 words
A method according to claim 5, wherein the cultivation is carried out with Cephalosporium polyaleurum 7-64 (ATCC-20415), Cephalosporium acremonium K-186 (ATCC-20416), or Emericellopsis microspora K-163 (ATCC-20422).
Claim 9
Dependent Claim
12 words
A method according to claim 1, wherein the microorganism is Streptomyces griseus.
Claim 10
Dependent Claim
12 words
A method according to claim 1, wherein the microorganism is Streptomyces hygroscopicus.
Claim 11
Dependent Claim
12 words
A method according to claim 1, wherein the microoganism is Anixiopsis peruviana.
Claim 12
Dependent Claim
12 words
A method according to claim 1, wherein the microorganism is Arachnomyces minimus.
Claim 13
Dependent Claim
12 words
A method according to claim 1, wherein the microorganism is Spiroidium fuscum.
Claim 14
Dependent Claim
14 words
A method according to claim 8, wherein the microorganism is Streptomyces griseus U-25 (ATCC-31031).
Claim 15
Dependent Claim
14 words
A method according to claim 9, wherein the microorganism is Streptomyces hygroscopicus U-442 (ATCC-31039).
Claim 16
Dependent Claim
14 words
A method according to claim 1, wherein the microorganism is Cephalosporium acremonium K-186 (ATCC-20416).
Claim 17
Dependent Claim
14 words
A method according to claim 1, wherein the microorganism is Cephalosporium polyaleurum 7-64 (ATCC-20415).
Claim 18
Dependent Claim
14 words
A method according to claim 1, wherein the microorganism is Emericellopsis microspora K-163 (ATCC-20422).
Claim 19
Dependent Claim
14 words
A method according to claim 1, wherein the microorganism is Paecilomyces carneus C-2237 (ATCC-20417).
Claim 20
Dependent Claim
14 words
A method according to claim 1, wherein the microorganism is Paecilomyces carneus C-4053 (IFO-9730).
Claim 21
Dependent Claim
14 words
A method according to claim 1, wherein the microorganism is Paecilomyces persicinus C-3009 (ATCC-20418).
Claim 22
Dependent Claim
13 words
A method according to claim 10, wherein the microorganism is Anixiopsis peruviana CBS-301.67.
Claim 23
Dependent Claim
14 words
A method according to claim 10, wherein the microorganism is Anixiopsis peruviana K-21 (ATCC-20419).
Claim 24
Dependent Claim
13 words
A method according to claim 11, wherein the microorganism is Arachnomyces minimus CBS-324.70.
Claim 25
Dependent Claim
14 words
A method according to claim 11, wherein the microorganism is Arachnomyces minimus K-154 (ATCC-20420).
Claim 26
Dependent Claim
13 words
A method according to claim 12, wherein the microorganism is Spiroidium fuscum IFO-5479.
Claim 27
Dependent Claim
14 words
A method according to claim 12, wherein the microorganism is Spiroidium fuscum K-461 (ATCC-20421).
Claim 28
Dependent Claim
14 words
A method according to claim 1, wherein the microorganism is of the genus Anixiopsis.
Claim 29
Dependent Claim
14 words
A method according to claim 1, wherein the microorganism is of the genus Arachnomyces.
Claim 30
Dependent Claim
14 words
A method according to claim 1, wherein the microorganism is of the genus Spiroidium.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-09-07 | 1980-03-08 | 1980-09-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-09-07 | 1984-03-08 | 1984-09-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-09-07 | 1988-03-08 | 1988-09-07 | $7700.00 | Window Closed / Lapsed |