US3978055A
Expired / Lapsed
US
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Arylamino pyrimidinic derivatives
Assignee: Synthelabo SA
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Filing: 1974-09-03
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Granted: 1976-08-31
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Expires: 1994-09-03
Abstract
Abstract Compounds of the formula WHEREIN Ar is phenyl or phenyl substituted by one or more halogens, by a trifluoromethyl or a methylenedioxy, by one or more methoxy, by an alkyl having one to 4 carbon atoms or by a dimethylamino, AND R is R1 -C-N ANGLE , PARALLEL OR2 or -O- R3 (CH2)n-N ANGLE , R4 or O C ANGLE OR5 wherein R1 and R2 each are hydrogen or alkyl of 1 to 4 carbon atoms, or R1 -N ANGLE R2 is pyrrolidino, morpholino, piperidino or piperazino N'-substituted by alkyl of 1 to 4 carbon atoms, or phenyl; R3 and R4 each are alkyl of 1 to 3 carbon atoms or R3 -N ANGLE R4 is morpholino, pyrrolidino, piperidino or hexamethyleneimino, n is an integer of 1 to 5; and R5 is alkyl of 1 to 4 carbon atoms, 2,3-dihydroxypropyl or 2,2-dimethyl dioxolan-4-yl methyl or hydroxycarbonylmethyl.
Inventors
- 👤 Claude P. Fauran
- 👤 Guy R. Bourgery
- 👤 Guy M Raynaud
- 👤 Claude J. Gouret
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 16:21
CPC Classifications
C; C07; C07D; C07D239/00; C07D239/02; C07D239/24; C07D239/28; C07D239/32; C07D239/42; C07D401/00; C07D401/02; C07D401/12
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
76 words
A compound having the formula ##SPC9## wherein Ar is phenyl or phenyl substituted by a halogen, or a trifluoromethyl, or a methylenedioxy, or one or more methoxy, or an alkyl having one to 4 carbon atoms or a dimethylamino, and wherein R is ##EQU12## wherein n is an integer from 1 to 5, and R 3 and R 4 each is alkyl having one to 3 carbon atoms, or ##EQU13## is morpholino, pyrrolidino, piperidino or hexamethyleneimino.
Claim 2
Dependent Claim
76 words
A compound having the formula ##SPC9## wherein Ar is phenyl or phenyl substituted by a halogen, or a trifluoromethyl, or a methylenedioxy, or one or more methoxy, or an alkyl having one to 4 carbon atoms or a dimethylamino, and wherein R is ##EQU12## wherein n is an integer from 1 to 5, and R 3 and R 4 each is alkyl having one to 3 carbon atoms, or ##EQU13## is morpholino, pyrrolidino, piperidino or hexamethyleneimino.
Claim 3
Dependent Claim
14 words
A compound as claimed in claim 1, in which Ar is phenyl and ##SPC10##
Claim 4
Dependent Claim
30 words
A compound as claimed in claim 1, in which Ar is phenyl and the symbol ##SPC11##is one of the following: 4-dimethylaminoethoxyphenyl, 4-di(n-propyl)-aminoethoxyphenyl, 4-pyrrolidinoethoxyphenyl, 4-piperidinoethoxyphenyl, 4-morpholinoethoxyphenyl, 2-morpholinoethoxyphenyl, 3-morpholinoethoxyphenyl, 4-hexamethyleneiminoethoxyphenyl and 4-morpholinopropoxyphenyl.
Claim 5
Dependent Claim
24 words
A compound as claimed in claim 1 in which Ar is 3-chlorophenyl and the symbol ##SPC12##is one of the following: 4-dimethylaminoethoxyphenyl, 4-hexamethyleneiminoethoxyphenyl and 4-morpholinoethoxyphenyl.
Claim 6
Dependent Claim
24 words
A compound as claimed in claim 1, in which Ar is a 4-chlorophenyl and the symbol ##SPC13##is one of the following: 4-dimethylaminoethoxyphenyl and 4-morpholinoethoxyphenyl.
Claim 7
Dependent Claim
24 words
A compound as claimed in claim 1, in which Ar is 3-fluorophenyl and the symbol ##SPC14##is one of the following: 4-dimethylaminoethoxyphenyl, 4-piperidinoethoxyphenyl, and 4-morpholinoethoxyphenyl.
Claim 8
Dependent Claim
24 words
A compound as claimed in claim 1, in which Ar is 3-trifluoromethylphenyl and the symbol ##SPC15##is one of the following: 4-dimethylaminoethoxyphenyl, 4-pyrrolidinoethoxyphenyl and 4-morpholinoethoxyphenyl.
Claim 9
Dependent Claim
17 words
A compound as claimed in claim 1, in which Ar is 3,4-methylenedioxyphenyl and the symbol ##SPC16##is 4-morpholinoethoxyphenyl.
Claim 10
Dependent Claim
25 words
A compound as claimed in claim 1, in which Ar is 3,4,5-trimethoxyphenyl and the symbol ##SPC17##is one of the following: 4-dimethylaminoethoxyphenyl, 4-morpholinoethoxyphenyl, 2-dimethylaminoethoxyphenyl and 2-morpholinoethoxyphenyl.
Claim 11
Dependent Claim
21 words
A compound as claimed in claim 1, in which Ar is 4-methoxyphenyl, 4-methylphenyl or 4-dimethylaminophenyl and the symbol ##SPC18## is 4-morpholinoethoxyphenyl.
References Cited (Backward Citations)
US3321478A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-08-31 | 1980-03-01 | 1980-08-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-08-31 | 1984-03-01 | 1984-08-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-08-31 | 1988-03-01 | 1988-08-31 | $7700.00 | Window Closed / Lapsed |