US3978051A
Expired / Lapsed
US
⏱️ 0.0 years remaining
7-Methoxy 7-α-ureidothienylacetamidocephalosporins
Assignee: ER Squibb and Sons LLC
•
Filing: 1973-08-23
•
Granted: 1976-08-31
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Expires: 1993-08-23
Abstract
Abstract Compounds of the formula WHEREIN R is H, heterocyclic thio; pyridinium; carbamoyloxy or acetoxy; Y is H, Cl, Br, NO2 or methylsulfonyl, and pharmaceutically acceptable salts and esters thereof are effective antibacterial agents.
Inventors
- 👤 Joseph Edward Dolfini
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 04:42
CPC Classifications
C; C07; C07D; C07D501/00; C07D501/14; C07D501/16; C07D501/20; C07D501/57
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
76 words
A compound of the formula: ##SPC14## wherein the 7-methoxy group occupies the α-configuration; R is ##SPC15## Y is H, Cl, Br, NO 2 or methylsulfonyl; and pharmaceutically acceptable salts thereof, straight or branched chain alkyl esters of 1 to 3 carbon atoms thereof, tertiary butyl ester thereof, benzhydryl ester thereof, trichloroethyl ester thereof, and acyloxymethyl esters thereof having the formula ##EQU1## wherein R' is lower alkyl of 1 to 5 carbon atoms, phenyl, benzyl or phenethyl.
Claim 2
Dependent Claim
76 words
A compound of the formula: ##SPC14## wherein the 7-methoxy group occupies the α-configuration; R is ##SPC15## Y is H, Cl, Br, NO 2 or methylsulfonyl; and pharmaceutically acceptable salts thereof, straight or branched chain alkyl esters of 1 to 3 carbon atoms thereof, tertiary butyl ester thereof, benzhydryl ester thereof, trichloroethyl ester thereof, and acyloxymethyl esters thereof having the formula ##EQU1## wherein R' is lower alkyl of 1 to 5 carbon atoms, phenyl, benzyl or phenethyl.
Claim 3
Dependent Claim
9 words
A compound of claim 1 wherein Y is H.
Claim 4
Dependent Claim
9 words
An acetoxymethyl ester of a compound of claim 2.
Claim 5
Dependent Claim
9 words
A pivaloyloxymethyl ester of a compound of claim 2.
Claim 6
Dependent Claim
9 words
A compound of claim 2 as the free acid.
Claim 7
Dependent Claim
10 words
A pharmaceutically acceptable salt of a compound of claim 1.
Claim 8
Dependent Claim
13 words
The benzhydryl, trichloroethyl or tertiary butyl ester of a compound of claim 1.
Claim 9
Dependent Claim
28 words
An acyloxymethyl ester of a compound of claim 1 having the formula ##STR2## wherein R' is lower alkyl of 1 to 5 carbon atoms, phenyl, benzyl, or phenethyl.
Claim 10
Dependent Claim
10 words
The compound of claim 5, 7-[2-ureido-2-(2-thienyl) acetamido]-7-methoxy-3-[2-(5-methyl-1,3,4-thiadiazolyl)thiomethyl]-Δ 3 -cephem-4-carboxylic acid.
Claim 11
Dependent Claim
10 words
The compound of claim 5, 7-[2-ureido-2-(2-thienyl) acetamido]-7-methoxy-3-[5-(3-methyl-1,2,4-thiadiazolyl)thiomethyl]-Δ 3 -cephem-4-carboxylic acid.
Claim 12
Dependent Claim
10 words
The compound of claim 5, 7-[2-ureido-2-(2-thienyl) acetamido]-7-methoxy-3-[5-(1-methyltetrazolyl)thiomethyl]-Δ 3 -cephem-4-carboxylic acid.
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Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-08-31 | 1980-03-01 | 1980-08-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-08-31 | 1984-03-01 | 1984-08-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-08-31 | 1988-03-01 | 1988-08-31 | $7700.00 | Window Closed / Lapsed |