US3975372A
Expired / Lapsed
US
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Preparation of 12,13-desepoxy-12,13-dehydrorosamicin
Assignee: Merck Sharp & Dohme LLC
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Filing: 1975-02-28
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Granted: 1976-08-17
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Expires: 1995-02-28
Abstract
Abstract Described is a novel process for the preparation of 12,13-desepoxy-12,13-dehydrorosamicin by reducing rosamicin in a mineral acid solution containing Cr + + cations. Rosamicin is an antibiotic elaborated by Micromonospora rosaria.
Inventors
- 👤 Ashit K. Ganguly
- 👤 Olga Sarre
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 16:13
CPC Classifications
C; C07; C07H; C07H17/00; C07H17/04; C07H17/08
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
37 words
A process for converting rosamicin into 12,13-desepoxy-12,13-dehydrorosamicin which comprises reducing rosamicin in a dilute mineral acid solution under an inert atmosphere containing as the reducing agent chromous ions derived from the chromous salt of a mineral acid.
Claim 2
Dependent Claim
37 words
A process for converting rosamicin into 12,13-desepoxy-12,13-dehydrorosamicin which comprises reducing rosamicin in a dilute mineral acid solution under an inert atmosphere containing as the reducing agent chromous ions derived from the chromous salt of a mineral acid.
Claim 3
Dependent Claim
26 words
A process as defined in claim 1 wherein the chromous ions are present in the range of from 2.0 to 2.2 moles per mole of rosamicin.
Claim 4
Dependent Claim
20 words
A process as defined in claim 1 wherein the dilute mineral acid solution is from about 0.5N to about 3N.
Claim 5
Dependent Claim
20 words
A process as defined in claim 1 wherein the reaction medium is maintained at from about 10°C to about 40°C.
Claim 6
Dependent Claim
22 words
A process as defined in claim 1 wherein the reduction is allowed to proceed for from about 8 to about 24 hours.
Claim 7
Dependent Claim
17 words
A process according to claim 1 wherein the reaction mixture is maintained between pH 0.8 and 2.
Claim 8
Dependent Claim
51 words
The process for converting rosamicin to 12,13-desepoxy-12,13-dehydrorosamicin which comprises reducing rosamicin at 25°C in 1N sulfuric acid under argon with chromous ions derived from chromous chloride wherein the mole ratio of chromous chloride to rosamicin is 2.2 to 1 and wherein the reduction is allowed to proceed for about 18 hours.
Claim 9
Dependent Claim
51 words
The process for converting rosamicin to 12,13-desepoxy-12,13-dehydrorosamicin which comprises reducing rosamicin at 25°C in 1N sulfuric acid under argon with chromous ions derived from chromous chloride wherein the mole ratio of chromous chloride to rosamicin is 2.2 to 1 and wherein the reduction is allowed to proceed for about 18 hours.
References Cited (Backward Citations)
US3657227A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-08-17 | 1980-02-16 | 1980-08-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-08-17 | 1984-02-16 | 1984-08-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-08-17 | 1988-02-16 | 1988-08-17 | $7700.00 | Window Closed / Lapsed |