US3975365A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Inhibitory octapeptides angiotensin II
Assignee: GD Searle LLC
•
Filing: 1975-01-27
•
Granted: 1976-08-17
•
Expires: 1995-01-27
Abstract
Abstract Octapeptide derivatives characterized by an oxygen or sulfur-containing moiety in the C-terminal position are potent inhibitors of the pharmacological effects of Angiotensin and possess the additional advantage of a favorable antagonist/agonist ratio.
Inventors
- 👤 Robert H. Mazur
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 22:07
CPC Classifications
C; C07; C07K; C07K7/00; C07K7/04; C07K7/14; C07K5/00; C07K5/04; C07K5/08; C07K5/0802; C07K5/0804; C07K5/0808; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
74 words
A compound of the formula ##EQU24## wherein X represents a sarcosine or aspartic acid residue, Y represents the residue of isoleucine or valine, n is 1, A is O, S, SO, SO 2 , and R is arylalkyl of the formula ##SPC2## wherein m is 1 or 2, w is hydrogen, halo, loweralkyl having 1-7 carbon atoms, or loweralkoxy having 1-7 carbon atoms, and the amino acid residues having L or DL stereochemical configuration.
Claim 2
Dependent Claim
74 words
A compound of the formula ##EQU24## wherein X represents a sarcosine or aspartic acid residue, Y represents the residue of isoleucine or valine, n is 1, A is O, S, SO, SO 2 , and R is arylalkyl of the formula ##SPC2## wherein m is 1 or 2, w is hydrogen, halo, loweralkyl having 1-7 carbon atoms, or loweralkoxy having 1-7 carbon atoms, and the amino acid residues having L or DL stereochemical configuration.
Claim 3
Dependent Claim
63 words
As in claim 1, a compound of the formula ##EQU25## wherein X represents a sarcosine or aspartic acid residue, Y represents the residue of isoleucine or valine, A represents O, S, SO, or SO 2 , w is hydrogen, halo, loweralkyl having 1-7 carbon atoms or loweralkoxy having 1-7 carbon atoms and the amino acid residues having the L or DL stereochemical configuration.
Claim 4
Dependent Claim
35 words
As in claim 1, a compound of the formula ##EQU26## wherein A represents O, S, SO, or SO 2 and w represents hydrogen, halo, loweralkyl having 1-7 carbon atoms or loweralkoxy having 1-7 carbon atoms.
Claim 5
Dependent Claim
15 words
The compound according to claim 1 wherein A represents S, w represents hydrogen or halo.
Claim 6
Dependent Claim
24 words
The compound according to claim 1 wherein R is loweralkyl having 1-7 carbon atoms and the amino acids having L or DL stereochemical configuration.
Claim 7
Dependent Claim
15 words
A compound according to claim 1, wherein the amino acids have the L stereochemical configuration.
Claim 8
Dependent Claim
13 words
A compound according to claim 1, wherein X represents an aspartic acid residue.
Claim 9
Dependent Claim
12 words
A compound according to claim 1, wherein X represents a sarcosine residue.
Claim 10
Dependent Claim
12 words
A compound according to claim 1, wherein Y represents an isoleucine residue.
Claim 11
Dependent Claim
12 words
A compound according to claim 1, wherein Y represents a valine residue.
Claim 12
Dependent Claim
9 words
The compound according to claim 1 which is L-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-S-benzyl-L-cysteine.
Claim 13
Dependent Claim
9 words
The compound according to claim 1 which is sarcosyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-S-benzyl-L-cysteine.
Claim 14
Dependent Claim
9 words
The compound according to claim 1 which is L-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-S-(p-chlorobenzyl)-L-cysteine.
Claim 15
Dependent Claim
9 words
The compound according to claim 1 which is L-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-O-(2-phenethyl)-serine.
References Cited (Backward Citations)
US3886134A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-08-17 | 1980-02-16 | 1980-08-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-08-17 | 1984-02-16 | 1984-08-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-08-17 | 1988-02-16 | 1988-08-17 | $7700.00 | Window Closed / Lapsed |