Modification of polystyrene by Friedel-Crafts reaction with substituted halo ethyl benzenes and haloethylphenols to make supports for solid phase peptide synthesis

Abstract

Abstract A process for producing reagents useful in organic synthesis, of the general formula ##SPC1## Wherein Z designates the ##EQU1## part of a polymeric backbone of a polymer like polystyrene, a copolymer comprising polystyrene and a comonomer like divinylbenzene, butadiene, and other copolymers comprising styrene, or wherein Z designates the aliphatic moiety of a long-chain aralkyl compound having a terminal phenyl moiety; n is an integer from 1 to 8, inclusive; R designates oxygen or sulfur; X designates nitro, carbonyl, carboxyl, cyano-carbalkoxy or a carboxamido group which may be substituted on the nitrogen atom, or a halogen atom, or alkyl, unsaturated alkyl, aralkyl; RH and X together designate hydroxytriazole; which comprises reacting a compound of the general formula ##SPC2## Wherein Y designates --Cl, --Br, or --OH and X and R are as defined above, with a polystyrene polymer or with a copolymer as defined above, or with a long-chain araliphatic compound as defined above, in a Friedel-Crafts reaction. According to a preferred embodiment copolymers of polystyrene and divinylbenzene are used. The invention also relates to the novel products obtained by the above reaction.

Inventors

• 👤 Abraham Patchornik
• 👤 Rami Kalir
• 👤 Matityahu Fridkin
• 👤 Abraham Warshavsky

Bibliographic Details