US3972911A
Expired / Lapsed
US
⏱️ 0.0 years remaining
N,N'(Cyano-phenylene)dioxamic acids and esters
Assignee: Pharmacia and Upjohn Co
•
Filing: 1974-06-10
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Granted: 1976-08-03
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Expires: 1994-06-10
Abstract
Abstract It has now been discovered that novel compounds of FIG. 1 ##SPC1## are useful in the prophylactic treatment of sensitized humans and animals for allergy and all anaphylactic reactions of a reagin or non-reagin mediated nature. Additionally, these compounds are intermediates to the acids and physiologically acceptable salts which also have the same biological utility. The compounds of the invention are formulated with pharmaceutical carriers for oral, parenteral, inhalation or rectal means of administration.
Inventors
- 👤 John B. Wright
- 👤 Charles M. Hall
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 18:38
CPC Classifications
C; C07; C07C; C07C67/00; C07C67/14
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
196 words
A compound of the formula ##SPC3## wherein W, X and Y are the same or different and are selected from the group consisting of hydrogen, alkyl from one to six carbon atoms, inclusive, phenyl, alkoxy with the alkyl group having from one to six carbon atoms, inclusive, hydroxy, nitro, halogen, trifluoromethyl and ##EQU1##wherein Q is selected from ##EQU2##and ##EQU3##wherein D is selected from the group consisting of hydrogen, alkyl from one to six carbon atoms, inclusive, phenyl, ##EQU4##and a physiologically acceptable metal or amine cation, m is 2 or 3. R 3 and R 4 are the same or different and are selected from the group consisting of hydrogen, alkyl from one to three carbon atoms, inclusive, R 1 and R 2 are the same or different and are selected from the group consisting of hydrogen, a physiologically acceptable metal or amine cation, alkyl of seven to twelve carbon atoms, inclusive, and cycloalkyl of four to eight carbon atoms, inclusive, with the proviso that when one of R 1 and R 2 is hydrogen or a physiologically acceptable metal or amine cation, the other variable is not hydrogen or a physiologically acceptable metal or amine cation.
Claim 2
Dependent Claim
196 words
A compound of the formula ##SPC3## wherein W, X and Y are the same or different and are selected from the group consisting of hydrogen, alkyl from one to six carbon atoms, inclusive, phenyl, alkoxy with the alkyl group having from one to six carbon atoms, inclusive, hydroxy, nitro, halogen, trifluoromethyl and ##EQU1##wherein Q is selected from ##EQU2##and ##EQU3##wherein D is selected from the group consisting of hydrogen, alkyl from one to six carbon atoms, inclusive, phenyl, ##EQU4##and a physiologically acceptable metal or amine cation, m is 2 or 3. R 3 and R 4 are the same or different and are selected from the group consisting of hydrogen, alkyl from one to three carbon atoms, inclusive, R 1 and R 2 are the same or different and are selected from the group consisting of hydrogen, a physiologically acceptable metal or amine cation, alkyl of seven to twelve carbon atoms, inclusive, and cycloalkyl of four to eight carbon atoms, inclusive, with the proviso that when one of R 1 and R 2 is hydrogen or a physiologically acceptable metal or amine cation, the other variable is not hydrogen or a physiologically acceptable metal or amine cation.
Claim 3
Dependent Claim
11 words
A compound in accordance with claim 1 wherein W is hydrogen.
Claim 4
Dependent Claim
13 words
A compound in accordance with claim 2 wherein W and Y are hydrogen.
Claim 5
Dependent Claim
14 words
A compound in accordance with claim 3 wherein W, X and Y are hydrogen.
Claim 6
Dependent Claim
67 words
A compound in accordance with claim 2 wherein X and Y are the same or different and are selected from the group consisting of hydrogen, alkyl from one to six carbon atoms, inclusive, phenyl, alkoxy with the alkyl group having from one to six carbon atoms, inclusive, hydroxy, nitro, halogen, trifluoromethyl, and ##STR33##with the proviso that when D is alkyl, the upper carbon atom limitation is three.
Claim 7
Dependent Claim
13 words
A compound in accordance with claim 5 wherein W and X are hydrogen.
Claim 8
Dependent Claim
57 words
A compound in accordance with claim 6 wherein Y is selected from the group consisting of hydrogen, alkyl of one to four carbon atoms, inclusive, phenyl, nitro, fluoro, chloro, trifluoromethyl and ##STR34##R 1 and R 2 are the same or different and are selected from the group consisting of cycloalkyl of four to seven carbon atoms, inclusive.
Claim 9
Dependent Claim
11 words
A compound in accordance with claim 7 wherein Y is hydrogen.
Claim 10
Dependent Claim
49 words
A compound in accordance with claim 7 wherein Y is at the 2 position and is the same as in claim 7 with the proviso that ##STR35##is limited to ##STR36##and R 1 and R 2 are the same or different and are cycloalkyl of five or six carbon atoms.
Claim 11
Dependent Claim
11 words
A compound in accordance with claim 9 wherein Y is hydrogen.
Claim 12
Dependent Claim
33 words
A compound in accordance with claim 1 wherein R 1 is the same as R 2 and neither R 1 nor R 2 is hydrogen or a physiologically acceptable metal or amine cation.
Claim 13
Dependent Claim
33 words
A compound in accordance with claim 5 wherein R 1 is the same as R 2 and neither R 1 nor R 2 is hydrogen or a physiologically acceptable metal or amine cation.
Claim 14
Dependent Claim
33 words
A compound in accordance with claim 7 wherein R 1 is the same as R 2 and neither R 1 nor R 2 is hydrogen or a physiologically acceptable metal or amine cation.
Claim 15
Dependent Claim
33 words
A compound in accordance with claim 9 wherein R 1 is the same as R 2 and neither R 1 nor R 2 is hydrogen or a physiologically acceptable metal or amine cation.
Claim 16
Dependent Claim
11 words
A compound in accordance with claim 3 wherein X is hydrogen.
Claim 17
Dependent Claim
11 words
A compound in accordance with claim 3 wherein X is 2-chloro.
Claim 18
Dependent Claim
11 words
A compound in accordance with claim 3 wherein X is 4-chloro.
References Cited (Backward Citations)
US3852324A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-08-03 | 1980-02-02 | 1980-08-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-08-03 | 1984-02-02 | 1984-08-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-08-03 | 1988-02-02 | 1988-08-03 | $7700.00 | Window Closed / Lapsed |