Process for preparing a 2(ω-aminoalkyl)-1,3-heterocyclic compounds

Claim 1

Process for preparing a 5-membered heterocycle which comprises reacting a diamine, aminohydroxy or aminothiol compound having the formula ##EQU13##wherein A is a bivalent aromatic radical selected from the group of o-phenylene and o-naphthylene and the foregoing substituted by halogen, nitro, amino which may also be mono- or di-substituted by lower alkyl, hydroxy, C 1-4 alkoxy, C 6-10 aryloxy, C 1-4 alkylmercapto, C 6-10 arylmercapto C 1-4 alkylsulfonyl or C 6-10 arylsulfonyl; X is oxygen, sulfur or the group >N -- R.sup.7 wherein R 7 is as defined herein with a lactam having the formula ##EQU14## wherein B is selected from the group of a single bond C 6-10 arylene, oxygen, sulfur and the group ##EQU15##wherein R 6 is as defined herein; R 1 , r 2 , r 3 and R 4 , which may be the same or different, are selected from the group of hydrogen, halogen nitro, and alkyl having up to 18 carbon atoms, cycloalkyl having 4 to 12 carbon atoms, phenylalkyl having up to 5 carbon atoms in the alkyl portion, phenyl and naphthyl and the foregoing substituted by halogen, nitro, amino which may also be mono- or di- substituted by lower alkyl, hydroxy, C 1-4 alkoxy, C 6-10 aryloxy, C 1-4 alkylmercapto, C 6-10 arylmercapto, C 1-4 alkylsulfonyl or C 6-10 arylsulfonyl; R 5 , r 6 and R 7 , which may be the same or different, are selected from the group of hydrogen and alkyl having up to 18 carbon atoms, cycloalkyl having 4 to 12 carbon atoms, phenylalkyl having up to 5 carbon atoms in the alkyl portion, phenyl and naphthyl and the foregoing substituted by halogen, nitro, amino which may also be mono- or di- substituted by lower alkyl, hydroxy, C 1-4 alkoxy, C 6-10 aryloxy, C 1-4 alkylmercapto, C 6-10 arylmercapto, C 1-4 alkylsulfonyl or C 6-10 arylsulfonyl; and n and m which may be the same or different, are integers of from 1 to 14, with the proviso that the sum of n and m does not exceed 15, at a temperature of from 100° to 300°C in the presence of an acid selected from the group of mineral acids, aliphatic and aromatic sulfonic acids, aliphatic and aromatic phosphonic acids and Lewis acids and/or an acid catalyst selected from the group of acid activated silicas and fuller earths, natural and synthetic acid ion exchangers and acid activated molecular sieves, in an amount of from 0.0001 to 2 times the equivalent quantity per mole of the lactam.