US3971780A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Thio-β-lactam cephalosporins
Assignee: ER Squibb and Sons LLC
•
Filing: 1975-02-19
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Granted: 1976-07-27
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Expires: 1995-02-19
Abstract
Abstract Thio-β-lactam cephalosporins of the general formula ##SPC1## Wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, trihaloethyl, alkali metal or alkaline earth metal; R 1 is hydrogen, lower alkyl, cycloalkyl, phenyl, phenoxy, phenyl-lower alkyl or certain heterocyclic groups; R 2 is hydrogen, amino, carboxy, hydroxy or ureido; and X is hydrogen, hydroxy, lower alkylthio, lower alkylthiadiazolyl, lower alkyltetrazolyl or lower alkanoyloxy, are useful as antimicrobial agents.
Inventors
- 👤 Christopher M. Cimarusti
- 👤 Paul Wojtkowski
- 👤 Joseph E. Dolfini
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 06:23
CPC Classifications
C; C07; C07D; C07D501/00; C07D501/14; C07D501/16; C07D501/20; C07D501/18
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
63 words
A compound of the formula ##SPC4## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, trihaloethyl, alkali metal or alkaline earth metal; R 1 is hydrogen, lower alkyl, saturated or unsaturated cycloalkyl of 3 to 7 carbons, phenyl, phenyl-lower alkyl, phenoxy, thienyl, furyl, oxazolyl, isoxazolyl, or thiazolyl; R 2 is hydrogen, amino, carboxy, hydroxy or ureido; and X is hydrogen, hydroxy or lower alkanoyloxy.
Claim 2
Dependent Claim
63 words
A compound of the formula ##SPC4## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, trihaloethyl, alkali metal or alkaline earth metal; R 1 is hydrogen, lower alkyl, saturated or unsaturated cycloalkyl of 3 to 7 carbons, phenyl, phenyl-lower alkyl, phenoxy, thienyl, furyl, oxazolyl, isoxazolyl, or thiazolyl; R 2 is hydrogen, amino, carboxy, hydroxy or ureido; and X is hydrogen, hydroxy or lower alkanoyloxy.
Claim 3
Dependent Claim
35 words
A compound as in claim 1 wherein R is hydrogen, alkali metal or trichloroethyl; R 1 is hydrogen, phenyl, thienyl or furyl; R 2 is hydrogen, amino or hydroxy and X is hydrogen or acetoxy.
Claim 4
Dependent Claim
11 words
A compound as in claim 1 wherein R 1 is phenyl.
Claim 5
Dependent Claim
11 words
A compound as in claim 1 wherein R 1 is thienyl.
Claim 6
Dependent Claim
14 words
A compound as in claim 2 wherein R and R 2 each is hydrogen.
Claim 7
Dependent Claim
19 words
A compound as in claim 1 wherein R, R 2 and X each is hydrogen, R 1 is phenoxy.
Claim 8
Dependent Claim
20 words
A compound as in claim 1 wherein R, R 2 and X each is hydrogen and R 1 is phenyl.
Claim 9
Dependent Claim
22 words
A compound as in claim 1 wherein R and R 2 each is hydrogen, R 1 is phenoxy and X is acetoxy.
Claim 10
Dependent Claim
22 words
A compound as in claim 1 wherein R and R 2 each is hydrogen, R 1 is phenyl and X is acetoxy.
Claim 11
Dependent Claim
59 words
A process for the production of a compound of claim 1 which comprises reacting a compound of the formula ##SPC5## wherein R, R 1 , R 2 and X have the same meaning as in claim 1, with an excess of boron sulfide in an inert organic solvent at a temperature in the range of about 30° to 80°C.
Claim 12
Dependent Claim
20 words
A process as in claim 10 wherein R 1 is phenoxy and R, R 2 and X each is hydrogen.
Claim 13
Dependent Claim
20 words
A process as in claim 10 wherein R 1 is phenyl, and R, R 2 and X each is hydrogen.
Claim 14
Dependent Claim
22 words
A process as in claim 10 wherein R 1 is phenoxy, R and R 2 each is hydrogen, and X is acetoxy.
References Cited (Backward Citations)
US3897422A
Cited
US3897423A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-07-27 | 1980-01-26 | 1980-07-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-07-27 | 1984-01-26 | 1984-07-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-07-27 | 1988-01-26 | 1988-07-27 | $7700.00 | Window Closed / Lapsed |