US3971700A
Expired / Lapsed
US
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Process for the enzymatic resolution of DL-phenyl glycine amide into its optically active antipodes
Assignee: Stamicarbon BV
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Filing: 1975-06-05
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Granted: 1976-07-27
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Expires: 1995-06-05
Abstract
Abstract Process for the resolution of DL-phenyl glycine amide through selective enzymatic hydrolysis with amino peptidase especially leucine amino peptidase.
Inventors
- 👤 Wilhelmus H. J. Boesten
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 17:43
CPC Classifications
C; C12; C12P; C12P41/00; C12P41/006; C12P13/00; C12P13/04
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
30 words
A process for preparing D-phenyl glycine amide and L-phenyl glycine, comprising hydrolyzing DL-phenyl glycine amide with an aminopeptidase and isolating D-phenyl glycine amide, L-phenyl glycine, or both by conventional techniques.
Claim 2
Dependent Claim
30 words
A process for preparing D-phenyl glycine amide and L-phenyl glycine, comprising hydrolyzing DL-phenyl glycine amide with an aminopeptidase and isolating D-phenyl glycine amide, L-phenyl glycine, or both by conventional techniques.
Claim 3
Dependent Claim
12 words
The process according to claim 1, wherein said aminopeptidase is leucine aminopeptidase.
Claim 4
Dependent Claim
25 words
The process according to claim 1, wherein said step of hydrolyzing is effected at a pH of 7-9.5 and a temperature of 20° to 40°C.
Claim 5
Dependent Claim
15 words
The process according to claim 1, wherein said aminopeptidase is used in an insoluble form.
Claim 6
Dependent Claim
20 words
The process according to claim 1, wherein D-phenyl glycine amide is separated and said amide is converted into D-phenyl glycine.
Claim 7
Dependent Claim
26 words
The process according to claim 5, wherein the amide is converted into D-phenyl glycine by treating the amide with an aqueous solution of a strong acid.
Claim 8
Dependent Claim
21 words
The process according to claim 6, wherein said acid is sulfuric acid, hydrochloric acid, benzene sulfonic acid or toluene sulfonic acid.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-07-27 | 1980-01-26 | 1980-07-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-07-27 | 1984-01-26 | 1984-07-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-07-27 | 1988-01-26 | 1988-07-27 | $7700.00 | Window Closed / Lapsed |