US3970561A
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Separation of compounds differing in isotopic composition
Assignee: Individual
•
Filing: 1975-03-11
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Granted: 1976-07-20
•
Expires: 1995-03-11
Abstract
Abstract Compounds differing in isotopic composition are separated by introducing a mixture of the compounds into a chromatographic column containing a lanthanide chelate as a stationary phase and eluting from the column a fraction which is at least enriched with one of the compounds of the mixture.
Inventors
- 👤 Robert E. Sievers
- 👤 Joseph J. Brooks
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 16:27
CPC Classifications
G; G21; G21F; G21F9/00; G21F9/04; G21F9/06; G21F9/12; B; B01; B01J; B01J20/00; B01J20/22; B01J20/223; B01J20/30; B01J20/32; B01J20/3202; B01J20/3204; B01J20/3206; B01J20/3208; B01J20/321; B01J20/3212; B01J20/3231; B01J20/3242; B01J20/3244; B01J20/3265; C; C01; C01B; C01B4/00; B01J2220/00; B01J2220/80; B01J2220/86; G01; G01N; G01N30/00; G01N30/02; G01N2030/022; G01N2030/025
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
93 words
A composition consisting essentially of a particulate support material and a solution of a lanthanide chelate coated thereon, the lanthanide chelate having the following structural formula: ##SPC2## wherein M is a rare earth element of the lanthanide series; R 1 , R 2 and R 3 are individually selected from the group consisting of hydrogen, deuterium, alkyl and fluoroalkyl; R 1 and R 2 together are d-camphor and R 3 is fluoroalkyl; X is water or an organic compound containing a donor group; and a is a numeral from zero to 4, inclusive.
Claim 2
Dependent Claim
93 words
A composition consisting essentially of a particulate support material and a solution of a lanthanide chelate coated thereon, the lanthanide chelate having the following structural formula: ##SPC2## wherein M is a rare earth element of the lanthanide series; R 1 , R 2 and R 3 are individually selected from the group consisting of hydrogen, deuterium, alkyl and fluoroalkyl; R 1 and R 2 together are d-camphor and R 3 is fluoroalkyl; X is water or an organic compound containing a donor group; and a is a numeral from zero to 4, inclusive.
Claim 3
Dependent Claim
13 words
The composition according to claim 1 in which the lanthanide chelate is tris(1,1,1,2,2,3,3,3-heptafluoro-7,7-dimethyloctane-4,6-dionato)europium(III).
Claim 4
Dependent Claim
13 words
The composition according to claim 1 in which the lanthanide chelate is tris(1,1,1,2,2,3,3,3-heptafluoro-7,7-dimethyloctane-4,6-dionato)praseodymium(III).
Claim 5
Dependent Claim
13 words
The composition according to claim 1 in which the lanthanide chelate is tris(1,1,1,2,2,3,3,7,7,7-decafluoro-4,6-heptanedionato)-europium(III)dihydrate.
Claim 6
Dependent Claim
13 words
The composition according to claim 1 in which the lanthanide chelate is tris(1,1,1,2,2,3,3,7,7,7-decafluoro-4,6-heptanedionato)-ytterbium(III).
Claim 7
Dependent Claim
13 words
The composition according to claim 1 in which the lanthanide chelate is tris(2,4-pentanedionato)lanthanum(III)dihydrate.
Claim 8
Dependent Claim
28 words
The composition according to claim 1 in which the support material is selected from the group consisting of acid washed, silanized diatomaceous earths, glass beads, and porous polymers.
Claim 9
Dependent Claim
20 words
The composition according to claim 7 in which the lanthanide chelate is in solution in a high molecular weight hydrocarbon.
Claim 10
Dependent Claim
63 words
The composition according to claim 1 in which the amount of solution coated on the support material ranges from about 0.5 to 20 weight percent, based on the weight of the support material, and the concentration of the lanthanide chelate in the solution ranges from an amount sufficient to provide an 0.05 molal solution to an amount sufficient to provide a saturated solution.
Claim 11
Dependent Claim
84 words
In a chromatographic column, a stationary phase comprising a lanthanide chelate having the following structural formula: ##SPC3## wherein M is a rare earth element of the lanthanide series; R 1 , R 2 and R 3 are individually selected from the group consisting of hydrogen, deuterium, alkyl and fluoroalkyl; or R 1 and R 2 together and d-camphor and R 3 is fluoroalkyl; X is water or an organic compound containing a donor group; and a is a numeral from zero to 4, inclusive.
Claim 12
Dependent Claim
84 words
In a chromatographic column, a stationary phase comprising a lanthanide chelate having the following structural formula: ##SPC3## wherein M is a rare earth element of the lanthanide series; R 1 , R 2 and R 3 are individually selected from the group consisting of hydrogen, deuterium, alkyl and fluoroalkyl; or R 1 and R 2 together and d-camphor and R 3 is fluoroalkyl; X is water or an organic compound containing a donor group; and a is a numeral from zero to 4, inclusive.
Claim 13
Dependent Claim
14 words
The stationary phase according to claim 10 in which the lanthanide chelate is tris(1,1,1,2,2,3,3,3-heptafluoro-7,7-dimethyloctane-4,6-dionato)europium(III).
Claim 14
Dependent Claim
14 words
The stationary phase according to claim 10 in which the lanthanide chelate is tris(1,1,1,2,2,3,3,3-heptafluoro-7,7-dimethyloctane-4,6-dionato)praseodymium(III).
Claim 15
Dependent Claim
14 words
The stationary phase according to claim 10 in which the lanthanide chelate is tris(1,1,1,2,2,3,3,7,7,7-decafluoro-4,6-heptanedionato)europium(III)dihydrate.
Claim 16
Dependent Claim
14 words
The stationary phase according to claim 10 in which the lanthanide chelate is tris(1,1,1,2,2,3,3,7,7,7-decafluoro-4,6-heptanedionato)ytterbium(III).
Claim 17
Dependent Claim
14 words
The stationary phase according to claim 10 in which the lanthanide chelate is tris(2,4-pentanedionato)lanthanum(III)dihydrate.
Claim 18
Dependent Claim
28 words
The stationary phase of claim 10 which consists essentially of a solution of the lanthanide chelate coated on a particulate support material which is packed in the column.
Claim 19
Dependent Claim
24 words
The stationary phase of claim 10 which consists essentially of a solution of the lanthanide chelate coated on the inside wall of the column.
References Cited (Backward Citations)
US3488921A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-07-20 | 1980-01-19 | 1980-07-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-07-20 | 1984-01-19 | 1984-07-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-07-20 | 1988-01-19 | 1988-07-20 | $7700.00 | Window Closed / Lapsed |