US3968236A
Expired / Lapsed
US
⏱️ 0.0 years remaining
2-Aminomethyl-5-hydroxy-4H-pyran-4-one and derivatives thereof
Assignee: Merck and Co Inc
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Filing: 1975-01-22
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Granted: 1976-07-06
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Expires: 1995-01-22
Abstract
Abstract The 2-aminomethyl-5-hydroxy-4H-pyran-4-ones of the present invention are disclosed to have pharmaceutical utility as skeletal muscle relaxants. Also disclosed are processes for the preparation of such pyranones; pharmaceutical compositions comprising such compounds; and method of treatment comprising administering such compounds and compositions when a muscle relaxant effect is indicated.
Inventors
- 👤 Joseph G. Atkinson
- 👤 Joshua Rokach
- 👤 Clarence S. Rooney
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 14:35
CPC Classifications
C; C07; C07D; C07D309/00; C07D309/34; C07D309/36; C07D309/40; A; A61; A61P; A61P21/00; A61P21/02
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
23 words
A compound having the structural formula: ##SPC3## wherein R is hydrogen or an α-amino acid acyl moiety or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
23 words
A compound having the structural formula: ##SPC3## wherein R is hydrogen or an α-amino acid acyl moiety or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
9 words
A compound according to claim 1 which is 2-aminomethyl-5-hydroxy-4H-pyran-4-one.
Claim 4
Dependent Claim
9 words
A compound according to claim 1 which is 2-amino-N-[(5-hydroxy-4H-pyran-4-on-2-yl)methyl]acetamide.
Claim 5
Dependent Claim
9 words
A compound according to claim 1 which is 2-amino-N-[(5-hydroxy-4H-pyran-4-on-2-yl)methyl]propionamide.
Claim 6
Dependent Claim
41 words
A pharmaceutical composition comprising a therapeutically effective amount in unitary dosage form of a compound having the formula: ##SPC4## wherein R is hydrogen or an α-amino acid acyl moiety or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier therefor.
Claim 7
Dependent Claim
41 words
A pharmaceutical composition comprising a therapeutically effective amount in unitary dosage form of a compound having the formula: ##SPC4## wherein R is hydrogen or an α-amino acid acyl moiety or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier therefor.
Claim 8
Independent Claim
45 words
A method of treatment of skeletal muscle hyperactivity comprising administering to a patient in need of such treatment a therapeutically effective amount of a compound having the formula: ##SPC5## wherein R is hydrogen or an α-amino acid acyl moiety or a pharmaceutically acceptable salt thereof.
Claim 9
Independent Claim
45 words
A method of treatment of skeletal muscle hyperactivity comprising administering to a patient in need of such treatment a therapeutically effective amount of a compound having the formula: ##SPC5## wherein R is hydrogen or an α-amino acid acyl moiety or a pharmaceutically acceptable salt thereof.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-07-06 | 1980-01-05 | 1980-07-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-07-06 | 1984-01-05 | 1984-07-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-07-06 | 1988-01-05 | 1988-07-06 | $7700.00 | Window Closed / Lapsed |