US3966928A
Expired / Lapsed
US
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Novel derivatives of pyridazine-2-oxide
Assignee: Colgate Palmolive Co
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Filing: 1974-02-21
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Granted: 1976-06-29
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Expires: 1994-02-21
Abstract
Abstract Novel pyridazine-2-oxide derivatives inclusive of 3-mercaptopyridazine-2-oxides, disulfides thereof, metal salts thereof and 3-(2-oxopyridazinyl)isothiouronium compounds having particular utility as antimicrobial agents per se and in skin cleansing detergent compositions, shampoos, hair dressing and the like.
Inventors
- 👤 Miriam L. Douglass
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 18:40
CPC Classifications
C; C07; C07F; C07F3/00; C07F3/003; A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/49; A61K8/494; A61Q; A61Q17/00; A61Q17/005; A61Q19/00; A61Q5/00; C07D; C07D237/00; C07D237/02; C07D237/06; C07D237/10; C07D237/18; C07F1/00; C07F1/005; A61Q5/02; A61Q5/06
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
127 words
A topical antimicrobial composition for improving the condition of the hair and skin comprising about 0.1 to 3% by weight of a compound of the formula ##SPC5## wherein R 1 , R 2 and R 3 are each hydrogen; R 4 is a metal selected from alkali metals, alkaline earth metals, transistion metals, group IIIA metals, IVA metals, VA metals, and a quaternary ammonium ion of the formula R 5 R 6 R 7 R 8 N + wherein R 5 , R 6 , R 7 and R 8 are each independently hydrogen, and C(NH 2 ) 2 X wherein X is selected from the group consisting of halide, sulfate, nitrate, acetate, tartarate, citrate and saccharinate and a sufficient amount of a compatible, non-toxic cosmetic vehicle.
Claim 2
Dependent Claim
127 words
A topical antimicrobial composition for improving the condition of the hair and skin comprising about 0.1 to 3% by weight of a compound of the formula ##SPC5## wherein R 1 , R 2 and R 3 are each hydrogen; R 4 is a metal selected from alkali metals, alkaline earth metals, transistion metals, group IIIA metals, IVA metals, VA metals, and a quaternary ammonium ion of the formula R 5 R 6 R 7 R 8 N + wherein R 5 , R 6 , R 7 and R 8 are each independently hydrogen, and C(NH 2 ) 2 X wherein X is selected from the group consisting of halide, sulfate, nitrate, acetate, tartarate, citrate and saccharinate and a sufficient amount of a compatible, non-toxic cosmetic vehicle.
Claim 3
Dependent Claim
36 words
A composition as defined in claim 1 wherein R 1-3 is hydrogen and R 4 is selected from an alkali or alkaline earth metal, a transition metal and said quaternary ammonium compound wherein X is halide.
Claim 4
Dependent Claim
32 words
A composition as defined in claim 1 wherein said compound is selected from the group consisting of 3-(2-oxopyridazinyl) isothiouronium chloride, 3-mercaptopyridazine-2-oxide, Bis[3-(2-oxopyridazinyl)] disulfide, sodium salt of 3-mercaptopyridazine-2-oxide and zinc salt of 3-mercaptopyridazine-2-oxide.
Claim 5
Dependent Claim
11 words
A composition according to claim 1 which is a hair dressing.
Claim 6
Dependent Claim
10 words
A composition according to claim 1 which is a shampoo.
Claim 7
Dependent Claim
12 words
A composition according to claim 1 which is a skin cleansing detergent.
Claim 8
Dependent Claim
53 words
A topical antimicrobial composition for improving the condition of the hair and skin comprising about 0.1 to 3% by weight of a compound of the formula ##SPC6## wherein R 1 , R 2 and R 3 is hydrogen and R 4 is sodium and a sufficient amount of a compatible, non-toxic cosmetic vehicle.
Claim 9
Dependent Claim
53 words
A topical antimicrobial composition for improving the condition of the hair and skin comprising about 0.1 to 3% by weight of a compound of the formula ##SPC6## wherein R 1 , R 2 and R 3 is hydrogen and R 4 is sodium and a sufficient amount of a compatible, non-toxic cosmetic vehicle.
Claim 10
Dependent Claim
10 words
A composition according to claim 7, which is a hairdressing.
Claim 11
Dependent Claim
10 words
A composition according to claim 7, which is a shampoo.
Claim 12
Dependent Claim
12 words
A composition according to claim 7, which is a skin cleansing detergent.
Claim 13
Dependent Claim
28 words
A method of improving the condition of the hair and skin by inhibiting the growth of Pityposporum ovale comprising applying thereto the compound as defined in claim 1.
Claim 14
Dependent Claim
28 words
A method of improving the condition of the hair and skin by inhibiting the growth of Pitrosporum ovale comprising applying thereto the compound as defined in claim 2.
Claim 15
Dependent Claim
26 words
A method of improving the condition the hair and skin by inhibiting the growth Pityrosporum ovale comprising applying thereto the compound as defined in claim 7.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-06-29 | 1979-12-29 | 1980-06-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-06-29 | 1983-12-29 | 1984-06-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-06-29 | 1987-12-29 | 1988-06-29 | $7700.00 | Window Closed / Lapsed |