US3966743A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Ortho fused cycloalkano-4-quinolone-3-carboxylic acid derivatives
Assignee: Roche Diagnostics GmbH
•
Filing: 1974-09-09
•
Granted: 1976-06-29
•
Expires: 1994-09-09
Abstract
Abstract Cycloalkano-quinolone derivatives having anti-microbial activity characterized by the formula:
Inventors
- 👤 Herbert Berger
- 👤 Alfred Rhomberg
- 👤 Kurt Stach
- 👤 Wolfgang Vomel
- 👤 Winfriede Sauer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 18:11
CPC Classifications
C; C07; C07D; C07D221/00; C07D221/02; C07D221/04; C07D221/06; C07D221/16; C07D221/08; C07D221/10
Claims Analysis
Total Claims: 37
Claim 1
Independent Claim
128 words
A cycloalkano-quinolone compound having the formula: ##SPC8## wherein one of R 1 and R 2 represents a member selected from the group consisting of hydrogen, halogen, nitro, amino and lower alkanoyl amino, and the other of R 1 and R 2 taken together with R 3 forms an alkylene bridge containing 3 to 5 carbon atoms, X is hydrogen or lower alkyl of up to 6 carbon atoms, which may be substituted by a member of the group consisting of halogen, hydroxyl, lower alkanoyloxy, lower alkoxy, phenoxy, benzyloxy, mercapto, lower alkylmercapto, lower carbocyclic arylsulfonyloxy, and lower alkylsulfonyloxy, or X is unsubstituted lower alkenyl including alkadienyl, or lower alkynyl, and Y is a member selected from the group consisting of hydroxyl and lower alkoxy; and the non-toxic salts thereof.
Claim 2
Dependent Claim
128 words
A cycloalkano-quinolone compound having the formula: ##SPC8## wherein one of R 1 and R 2 represents a member selected from the group consisting of hydrogen, halogen, nitro, amino and lower alkanoyl amino, and the other of R 1 and R 2 taken together with R 3 forms an alkylene bridge containing 3 to 5 carbon atoms, X is hydrogen or lower alkyl of up to 6 carbon atoms, which may be substituted by a member of the group consisting of halogen, hydroxyl, lower alkanoyloxy, lower alkoxy, phenoxy, benzyloxy, mercapto, lower alkylmercapto, lower carbocyclic arylsulfonyloxy, and lower alkylsulfonyloxy, or X is unsubstituted lower alkenyl including alkadienyl, or lower alkynyl, and Y is a member selected from the group consisting of hydroxyl and lower alkoxy; and the non-toxic salts thereof.
Claim 3
Dependent Claim
14 words
Compound as claimed in claim 1 wherein X is hydrogen, lower alkyl or alkenyl.
Claim 4
Dependent Claim
39 words
Compound as claimed in claim 1 wherein X is substituted lower alkyl wherein the substituent is selected from the group consisting of halogen, hydroxyl, lower alkanoyloxy, lower alkoxy, phenoxy, benzyloxy, mercapto, lower alkylmercapto, lower carbocyclic arylsulfonyoxy, and lower alkylsulfonyloxy.
Claim 5
Dependent Claim
10 words
Compound as claimed in claim 1 wherein X is allenyl.
Claim 6
Dependent Claim
11 words
Compound as claimed in claim 1 wherein X is lower alkynyl.
Claim 7
Dependent Claim
15 words
Compound as claimed in claim 1 in the form of a pharmaceutically acceptable salt thereof.
Claim 8
Dependent Claim
13 words
Compound as claimed in claim 1 wherein said salt is a base salt.
Claim 9
Dependent Claim
56 words
N-vinyl-quinolone compound as claimed in claim 1 of the formula: ##SPC9## wherein one of the symbols R 1 and R 2 is hydrogen and the other one, together with R 3 , represents a 1,3-propylene bridge; R 4 is hydrogen or lower alkyl; and Y is hydroxyl, or lower alkoxy; and the pharmacologically compatible salts thereof.
Claim 10
Dependent Claim
11 words
Compound as claimed in claim 8 wherein R 1 is hydrogen.
Claim 11
Dependent Claim
11 words
Compound as claimed in claim 8 wherein R 2 is hydrogen.
Claim 12
Dependent Claim
11 words
Compound as claimed in claim 8 wherein R 4 is hydrogen.
Claim 13
Dependent Claim
10 words
Compound as claimed in claim 8 wherein Y is hydroxyl.
Claim 14
Dependent Claim
62 words
Cycloalkanoquinolone-carboxylic acid ester compounds as claimed in claim 1, of the formula ##SPC10## wherein R is lower alkyl; X is lower carbocyclic alkyl or substituted lower alkyl wherein the substituent is one member selected from chlorine, hydroxy, lower alkoxy, lower alkanoyloxy, lower alkylthio, lower alkylsulfonyloxy and lower carbocyclic aryl sulfonyloxy; or X is lower alkenyl; and n is 3, 4 or 5.
Claim 15
Dependent Claim
17 words
Compound as claimed in claim 13 wherein R is alkyl of from 1 to 5 carbon atoms.
Claim 16
Dependent Claim
17 words
Compound as claimed in claim 13 wherein X is alkyl of from 1 to 5 carbon atoms.
Claim 17
Dependent Claim
49 words
Compound as claimed in claim 13 wherein X is substituted alkyl of from 1 to 5 carbon atoms, wherein the substituent is chlorine, hydroxy, alkoxy of from 1 to 5 carbon atoms, alkanoyl of from 1 to 5 carbon atoms, or alkylthio of from 1 to 5 carbon atoms.
Claim 18
Dependent Claim
17 words
Compound as claimed in claim 13 wherein X is alkenyl of from 1 to 5 carbon atoms.
Claim 19
Dependent Claim
8 words
Compound as claimed in claim 1 designated 1-ethyl-1,4-dihydro-3-carboxy-cyclopentano(h)-quinolone-(4).
Claim 20
Dependent Claim
8 words
Compound as claimed in claim 1 designated 1-propyl-1,4-dihydro-3-carboxy-cyclopentano(h)-quinolone-(4).
Claim 21
Dependent Claim
8 words
Compound as claimed in claim 1 designated 1-allyl-1,4-dihydro-3-carboxy-cyclopentano(h)-quinolone-(4).
Claim 22
Dependent Claim
8 words
Compound as claimed in claim 1 designated 1-ethyl-1,4-dihydro-3-carboxy-cyclopentano(g)-quinolone-(4).
Claim 23
Dependent Claim
8 words
Compound as claimed in claim 1 designated 1-ethyl-1,4-dihydro-3-carboxy-8-amino-cyclopentano-(g)-quinolone-(4).
Claim 24
Dependent Claim
8 words
Compound as claimed in claim 1 designated 1-ethyl-1,4-dihydro-3-carboxy-8-chloro-cyclopentano-(g)-quinolone-(4).
Claim 25
Dependent Claim
8 words
Compound as claimed in claim 1 designated 1-ethyl-1,4-dihydro-3-carboxy-6-chloro-cyclopentano-(h)-quinolone-(4).
Claim 26
Dependent Claim
8 words
Compound as claimed in claim 1 designated 1-ethyl-1,4-dihydro-3-carboxy-6-formylamino-cyclopentano-(h)-quinolone-(4)
Claim 27
Dependent Claim
8 words
Compound as claimed in claim 1 designated 1-allenyl-3-carboxy-1,4-dihydro-cyclopentano-(h)-quinolone-(4).
Claim 28
Dependent Claim
8 words
Compound as claimed in claim 1 designated 1-propyl-1,4-dihydro-3-carboxy-6-formylamino-cyclopentano-(h)-quinolone-(4).
Claim 29
Dependent Claim
8 words
Compound as claimed in claim 1 designated 1-allyl-3-carboxy-1,4-dihydro-6-amino-cyclopentano-(h)-quinolone-(4).
Claim 30
Dependent Claim
8 words
Compound as claimed in claim 1 designated 1-allyl-3-carboxy-1,4-dihydro-6-formylamino-cyclopentano-(h)-quinolone-(4).
Claim 31
Dependent Claim
8 words
Compound as claimed in claim 1 designated 1-[propen-(1')-yl-(1')]-1,4-dihydro-3-carboxy-cyclopentano-(h)-quinolone-(4).
Claim 32
Dependent Claim
8 words
Compound as claimed in claim 1 designated 1-ethyl-3-carbethoxy-1,4-dihydrocyclopentano(h)quinolone-(4).
Claim 33
Dependent Claim
8 words
Compound as claimed in claim 1 designated 1-ethyl-3-carbomethoxy-1,4-dihydrocyclopentano(h)quinolone-(4).
Claim 34
Dependent Claim
8 words
Compound as claimed in claim 1 designated 1-ethyl-3-carbopropoxy-1,4-dihydrocyclopentano(h)quinolone-(4).
Claim 35
Dependent Claim
8 words
Compound as claimed in claim 1 designated 1-[β-chloroethyl]-3-carbethoxy-1,4-dihydrocyclopentano(h)quinolone-(4).
Claim 36
Dependent Claim
8 words
Compound as claimed in claim 1 designated 1-[β-hydroxyethyl]-3-carbethoxy-1,4-dihydrocyclopentano(h)quinolone-(4).
Claim 37
Dependent Claim
8 words
Compound as claimed in claim 1 designated 1-[β-methoxyethyl]-3-carbethoxy-1,4-dihydrocyclopentano(h)quinolone-(4).
References Cited (Backward Citations)
US2966489A
Cited
US3324135A
Cited
US3287458A
Cited
US3524858A
Cited
GB1210638A
Cited
DE1770951A1
Cited
US3506667A
Cited
FR2054503A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-06-29 | 1979-12-29 | 1980-06-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-06-29 | 1983-12-29 | 1984-06-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-06-29 | 1987-12-29 | 1988-06-29 | $7700.00 | Window Closed / Lapsed |