US3966724A
Expired / Lapsed
US
⏱️ 0.0 years remaining
1-(α-Aminomethylbenzyl)isoquinoline compounds
Assignee: Armour Pharmaceutical Co
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Filing: 1974-12-20
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Granted: 1976-06-29
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Expires: 1994-12-20
Abstract
Abstract Compounds having the structure: ##SPC1## In which R 1 and R 2 are alkoxy groups of one to four carbon atoms, R 3 and R 4 each is hydrogen or an alkoxy group of one to four carbon atoms, and R 5 and R 6 each is an alkyl group of one to four carbon atoms or an arylalkyl group such as benzyl or R 5 taken with R 6 and N are pyrrolidinyl, piperidino, or morpholino groups and the pharmaceutically acceptable salts thereof and processes for preparing these compounds. These compounds are useful as vasodilators.
Inventors
- 👤 John Lawrence Hughes
- 👤 Jay Kenneth Seyler
- 👤 Carroll M. Smith
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 12:25
CPC Classifications
C; C07; C07D; C07D217/00; C07D217/12; C07D217/18; C07D217/20
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
80 words
A compound having the structure: ##SPC8## in which R 1 and R 2 are alkoxy groups of one to four carbon atoms, R 3 and R 4 each is hydrogen or an alkoxy group of one to four carbon atoms, and R 5 and R 6 each is an alkyl group of one to four carbon atoms or benzyl or R 5 taken with R 6 and N are pyrrolidinyl, piperidino, or morpholino groups and the pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
80 words
A compound having the structure: ##SPC8## in which R 1 and R 2 are alkoxy groups of one to four carbon atoms, R 3 and R 4 each is hydrogen or an alkoxy group of one to four carbon atoms, and R 5 and R 6 each is an alkyl group of one to four carbon atoms or benzyl or R 5 taken with R 6 and N are pyrrolidinyl, piperidino, or morpholino groups and the pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
61 words
A compound having the structure: ##SPC9## in which R 1 and R 2 are alkoxy groups of one to four carbon atoms, R 3 and R 4 each is hydrogen or an alkoxy group of one to four carbon atoms, and R 5 and R 6 each is an alkyl group of one to four carbon atoms or a benzyl group.
Claim 4
Dependent Claim
61 words
A compound having the structure: ##SPC9## in which R 1 and R 2 are alkoxy groups of one to four carbon atoms, R 3 and R 4 each is hydrogen or an alkoxy group of one to four carbon atoms, and R 5 and R 6 each is an alkyl group of one to four carbon atoms or a benzyl group.
Claim 5
Dependent Claim
34 words
The compound of claim 1 in which R 1 , r 2 , r 3 and R 4 each is a methoxy group and R 5 and R 6 each is a methyl group.
Claim 6
Dependent Claim
37 words
The compound of claim 1 in which R 1 , r 2 , r 3 and R 4 each is a methoxy group and R 5 and R 6 taken together with N is a piperidino group.
Claim 7
Dependent Claim
36 words
The compound of claim 1 in which R 1 , r 2 , r 3 and R 4 each is a methoxy group, R 5 is a methyl group and R 6 is a benzyl group.
Claim 8
Dependent Claim
37 words
The compound of claim 1 in which R 1 , r 2 , r 3 and R 4 each is a methoxy group and R 5 and R 6 taken together with N is a morpholino group.
Claim 9
Dependent Claim
34 words
The compound of claim 1 in which R 1 , r 2 , r 3 and R 4 each is a methoxy group and R 5 and R 6 each is an n-butyl group.
Claim 10
Dependent Claim
38 words
The compound of claim 1 in which R 1 and R 2 each is a methoxy group, R 3 and R 4 each is hydrogen, R 5 is a methyl group and R 6 is a benzyl group.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-06-29 | 1979-12-29 | 1980-06-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-06-29 | 1983-12-29 | 1984-06-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-06-29 | 1987-12-29 | 1988-06-29 | $7700.00 | Window Closed / Lapsed |