Patent US5028492A successfully refreshed from Google Patents.
US3966701A
Expired / Lapsed
US
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Fibrinogen peptide derivatives
Assignee: Dow Chemical Co
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Filing: 1973-11-07
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Granted: 1976-06-29
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Expires: 1993-11-07
Abstract
Abstract Fibrinogen peptide derivatives which have biological activity as anticoagulants of blood having the dipeptide moiety prolylarginine or the tripeptide moiety glycylprolylarginine, e.g., L-prolyl-L-arginine benzyl ester p-toluenesulfonate trifluoroacetate, glycyl-L-prolyl-L-arginine benzyl ester p-toluenesulfonate trifluoroacetate, N-t-butyloxycarbonyl-L-prolyl-L-arginine benzyl ester p-toluenesulfonate methanolate, N-benzyloxycarbonyl-prolyl-L-arginine benzyl ester p-toluenesulfonate methanolate and N-t-butyloxycarbonylglycol-L-prolyl-L-arginine benzyl ester p-toluenesulfonate.
Inventors
- 👤 Linneaus C. Dorman
- 👤 Roberta C. Cheng
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 12:51
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/06; C07K5/06139; C07K5/06165; C07K5/08; C07K5/0802; C07K5/0804; C07K5/0806
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
53 words
A C-terminal- or C-terminal- and N-terminal-protected lower peptide of the class of dipeptide and tripeptide salts of a pharmaceutically-acceptable acid wherein the dipeptide moiety is L-prolyl-L-arginine and the tripeptide moiety is glycyl-L-prolyl-L-arginine and a methanolate solvate thereof, wherein the C-terminal protective group is benzyl and the N-terminal protective group is benzyloxycarbonyl or tert.-butyloxycarbonyl.
Claim 2
Dependent Claim
53 words
A C-terminal- or C-terminal- and N-terminal-protected lower peptide of the class of dipeptide and tripeptide salts of a pharmaceutically-acceptable acid wherein the dipeptide moiety is L-prolyl-L-arginine and the tripeptide moiety is glycyl-L-prolyl-L-arginine and a methanolate solvate thereof, wherein the C-terminal protective group is benzyl and the N-terminal protective group is benzyloxycarbonyl or tert.-butyloxycarbonyl.
Claim 3
Dependent Claim
34 words
A compound of the group consisting of N-tert-butyloxycarbonyl-L-prolyl-L-arginine benzyl ester p-toluenesulfonate methanolate, L-prolyl-L-arginine benzyl ester p-toluenesulfonate trifluoroacetate, N-tert-butyloxycarbonylglycyl-L-prolyl-L-arginine benzyl ester p-toluene sulfonate, glycyl-L-prolyl-L-arginine benzyl ester p-toluene sulfonate trifluoroacetate and N-benzyloxycarbonyl-L-prolyl-L-arginine benzyl ester p-toluenesulfonate methanolate.
Claim 4
Dependent Claim
34 words
A compound of the group consisting of N-tert-butyloxycarbonyl-L-prolyl-L-arginine benzyl ester p-toluenesulfonate methanolate, L-prolyl-L-arginine benzyl ester p-toluenesulfonate trifluoroacetate, N-tert-butyloxycarbonylglycyl-L-prolyl-L-arginine benzyl ester p-toluene sulfonate, glycyl-L-prolyl-L-arginine benzyl ester p-toluene sulfonate trifluoroacetate and N-benzyloxycarbonyl-L-prolyl-L-arginine benzyl ester p-toluenesulfonate methanolate.
Claim 5
Dependent Claim
12 words
The compound of claim 2 which is N-tert-butyloxy-carbonyl-L-prolyl-L-anginine benzyl ester p-toluenesulfonate methanolate.
Claim 6
Dependent Claim
12 words
The compound of claim 2 which is L-prolyl-L-arginine benzyl ester p-toluenesulfonate trifluoroacetate.
Claim 7
Dependent Claim
11 words
The compound of claim 2 which is N-tert-butyloxycarbonylglycyl-L-prolyl-L-arginine benzyl ester p-toluenesulfonate.
Claim 8
Dependent Claim
12 words
The compound of claim 2 which is glycyl-L-prolyl-L-arginine benzyl ester p-toluenesulfonate trifluoroacetate.
Claim 9
Dependent Claim
12 words
The compound of claim 2 which is N-benzyloxycarbonyl-L-prolyl-L-arginine benzyl ester p-toluenesulfonate methanolate.
References Cited (Backward Citations)
US3778426A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-06-29 | 1979-12-29 | 1980-06-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-06-29 | 1983-12-29 | 1984-06-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-06-29 | 1987-12-29 | 1988-06-29 | $7700.00 | Window Closed / Lapsed |